Utility of a pharmacogenetic-driven algorithm in guiding dual antiplatelet therapy for patients undergoing coronary drug-eluting stent implantation in China

Purposes The POPular Risk Score (PRiS), a pharmacogenetic-driven algorithm consisting of CYP2C19 genotype, platelet reactivity, and clinical risk factors, is developed to evaluate ischemic risk and guide dual antiplatelet therapy (DAPT). This study aimed to evaluate the efficacy and safety of DAPT i...

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Veröffentlicht in:	European journal of clinical pharmacology 2022-02, Vol.78 (2), p.215-225
Hauptverfasser:	Lyu, Si-qi, Zhu, Jun, Wang, Juan, Wu, Shuang, Zhang, Han, Shao, Xing-hui, Yang, Yan-min
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Algorithms Antiplatelet therapy Asians - genetics Aspirin - therapeutic use Biomedical and Life Sciences Biomedicine Bleeding Cardiovascular Diseases Cerebral infarction China Clinical trials Clopidogrel Clopidogrel - therapeutic use Comorbidity Cytochrome P-450 CYP2C19 - genetics Drug delivery Drug-Eluting Stents Dual Anti-Platelet Therapy - adverse effects Dual Anti-Platelet Therapy - methods Female Genotypes Health Behavior Hemorrhage - chemically induced Humans Implants Ischemia Male Middle Aged Myocardial infarction Patients Pharmacogenetics Pharmacology/Toxicology Platelet Aggregation Inhibitors - adverse effects Purinergic P2Y Receptor Antagonists - adverse effects Risk Assessment Risk Factors Sociodemographic Factors Stents Thrombosis Ticagrelor Ticlopidine - therapeutic use
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