Tapering of TNF inhibitors in axial spondyloarthritis in routine care — 2-year clinical and MRI outcomes and predictors of successful tapering

Tapering of TNF inhibitors in axial spondyloarthritis in routine care — 2-year clinical and MRI outcomes and predictors of successful tapering

Abstract Objectives In a 2-year follow-up study of patients with axial spondyloarthritis (axSpA) in clinical remission who tapered TNF inhibitor (TNFi) treatment according to a clinical guideline, we aimed to investigate the proportion who successfully tapered/discontinued therapy and baseline predi...

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Veröffentlicht in:Rheumatology (Oxford, England) England), 2022-05, Vol.61 (6), p.2398-2412
Hauptverfasser: Wetterslev, Marie, Georgiadis, Stylianos, Sørensen, Inge Juul, Pedersen, Susanne Juhl, Christiansen, Sara Nysom, Hetland, Merete Lund, Brahe, Cecilie Heegaard, Bakkegaard, Mads, Duer, Anne, Boesen, Mikael, Gosvig, Kasper Kjærulf, Møller, Jakob Møllenbach, Krogh, Niels Steen, Jensen, Bente, Madsen, Ole Rintek, Christensen, Jan, Hansen, Annette, Nørregaard, Jesper, Røgind, Henrik, Østergaard, Mikkel
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Sprache:eng
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Zusammenfassung:Abstract Objectives In a 2-year follow-up study of patients with axial spondyloarthritis (axSpA) in clinical remission who tapered TNF inhibitor (TNFi) treatment according to a clinical guideline, we aimed to investigate the proportion who successfully tapered/discontinued therapy and baseline predictors thereof. The proportion regaining clinical remission after flare and the progression on MRI/radiography were also assessed. Methods One-hundred-and-nine patients (78 [72%]/31 [28%] receiving standard and reduced dose, respectively) in clinical remission (BASDAI 
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keab755