AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice

Renal tubulointerstitial fibrosis was a crucial pathological feature of diabetic nephropathy (DN), and renal tubular injury might associate with abnormal mitophagy. In this study, we investigated the effects and molecular mechanisms of AMPK agonist metformin on mitophagy and cellular injury in renal...

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Veröffentlicht in:	Cell death & disease 2021-10, Vol.12 (10), p.925-925, Article 925
Hauptverfasser:	Han, Ya-chun, Tang, Shi-qi, Liu, Yu-ting, Li, Ai-mei, Zhan, Ming, Yang, Ming, Song, Na, Zhang, Wei, Wu, Xue-qin, Peng, Can-hui, Zhang, Hao, Yang, Shikun
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 14/1 14/19 14/28 14/34 64/60 692/308/1426 692/699/1585/104/1586 692/699/2743/137/138 8-Hydroxy-2'-Deoxyguanosine - metabolism Agonists AMP-Activated Protein Kinases - metabolism Animals Antibodies Biochemistry Biomedical and Life Sciences Blood Glucose - metabolism Blood Urea Nitrogen Cell Biology Cell Culture Cell Line Collagen Type I - metabolism Creatinine Creatinine - blood Cytoplasm Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - pathology Diabetic nephropathy Diet, High-Fat Drinking water Fibronectins - metabolism Fibrosis High fat diet Humans Immunology Interleukin-1beta - metabolism Kidney - pathology Kidney - ultrastructure Kidneys Life Sciences Metformin Metformin - pharmacology Mice Mice, Inbred C57BL Mitochondria Mitochondria - metabolism Mitochondria - ultrastructure Mitophagy Mitophagy - drug effects Molecular modelling Nephropathy NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Overexpression Oxidation Oxidative stress Oxidative Stress - drug effects Parkin protein Phosphorylation - drug effects Protein Kinases - metabolism PTEN-induced putative kinase Reactive Oxygen Species - metabolism siRNA Streptozocin Ubiquitin-Protein Ligases - metabolism
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