Total Synthesis of the Spider-Venom Peptide Hi1a

Hi1a is a venom peptide from the Australian funnel-web spider Hadronyche infensa with a complex tertiary structure. Hi1a has neuroprotective and cardioprotective properties due to its potent inhibition of acid-sensing ion channel 1a (ASIC1a) and is currently being pursued as a novel therapy for acut...

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Veröffentlicht in:	Organic letters 2021-11, Vol.23 (21), p.8375-8379
Hauptverfasser:	Duggan, Nisharnthi M, Saez, Natalie J, Clayton, Daniel, Budusan, Elena, Watson, Emma E, Tucker, Isaac J, Rash, Lachlan D, King, Glenn F, Payne, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Sensing Ion Channels - chemistry Animals Molecular Structure Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology Spider Venoms - chemistry Spider Venoms - pharmacology Spiders - chemistry
Online-Zugang:	Volltext
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