Increased hemoglobin A1c level associates with low left atrial appendage flow velocity in patients of atrial fibrillation

Increased hemoglobin A1c level associates with low left atrial appendage flow velocity in patients of atrial fibrillation

High hemoglobin A1c (HbAlc) level is associated with increased cardiovascular disease risk and thromboembolic events [1]. The study sought to explored the association between HbAlc and left atrial appendage flow velocity (LAAV) among non-valvular atrial fibrillation (AF) patients. A total of 249 con...

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Veröffentlicht in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2021-10, Vol.31 (11), p.3176-3183
Hauptverfasser: Wei, Ying, Cui, Ming, Liu, Shuwang, Yu, Haiyi, Feng, Jieli, Gao, Wei, Li, Lei
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Atrial fibrillation
Hemoglobin A1c
Left atrial appendage flow velocity
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container_end_page 3183
container_issue 11
container_start_page 3176
container_title Nutrition, metabolism, and cardiovascular diseases
container_volume 31
creator Wei, Ying
Cui, Ming
Liu, Shuwang
Yu, Haiyi
Feng, Jieli
Gao, Wei
Li, Lei
description High hemoglobin A1c (HbAlc) level is associated with increased cardiovascular disease risk and thromboembolic events [1]. The study sought to explored the association between HbAlc and left atrial appendage flow velocity (LAAV) among non-valvular atrial fibrillation (AF) patients. A total of 249 consecutive non-valvular AF patients who underwent transesophageal echocardiography (TEE) were divided into two subgroups according to the median of LAAV level (
doi_str_mv 10.1016/j.numecd.2021.07.024
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The study sought to explored the association between HbAlc and left atrial appendage flow velocity (LAAV) among non-valvular atrial fibrillation (AF) patients. A total of 249 consecutive non-valvular AF patients who underwent transesophageal echocardiography (TEE) were divided into two subgroups according to the median of LAAV level (&lt;45 cm/s, ≥45 cm/s). Blood samples and other baseline clinical data of all patients were collected and analyzed. The low LAAV group included 126 patients and the high LAAV group included 123 patients. Patients in the low LAAV group were older and had a higher percentage of persistent AF, chronic heart failure, and higher CHA2DS2-VASc score (P &lt; 0.05). HbAlc level in the low LAAV group was significantly higher than the high LAAV group [6.1 (5.7–6.5)% vs 5.9 (5.6–6.2)%, P = 0.010]. The low LAAV group had larger left atrial diameter (LAD), left atrial area (LAA), higher left atrial pressure (LAP), and lower left ventricular ejection fraction (LVEF) (P &lt; 0.05). Spearman rank correlation analysis showed that the HbAlc level was negatively correlated with LAAV (r = −0.211, P = 0.001). Multivariate analysis indicated that female gender (OR = 2.233, 95% CI 1.110–4.492, P = 0.024), persistent AF (OR = 6.610, 95% CI 3.109–14.052, P &lt; 0.001), and HbAlc (OR = 1.903, 95% CI 1.092–3.317, P = 0.023) were independent factors that associated with low LAAV in AF patients. Increased HbAlc level is associated with decreased LAAV and may reflect a low contractile function of the left atrial appendage. •Increased HbAlc level is associated with decreased LAAV in AF patients.•HbAlc level may reflect a low contractile function of the left atrial appendage.•Improving glycemic control may be helpful in reducing the risk of thrombus events in AF patients.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2021.07.024</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Atrial fibrillation ; Hemoglobin A1c ; Left atrial appendage flow velocity</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2021-10, Vol.31 (11), p.3176-3183</ispartof><rights>2021 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-9b037914708cbb1b18f90d66a01d4e32e619c7ebff4edfc0704587186f7aa5053</citedby><cites>FETCH-LOGICAL-c385t-9b037914708cbb1b18f90d66a01d4e32e619c7ebff4edfc0704587186f7aa5053</cites><orcidid>0000-0002-7627-1945</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939475321003458$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Wei, Ying</creatorcontrib><creatorcontrib>Cui, Ming</creatorcontrib><creatorcontrib>Liu, Shuwang</creatorcontrib><creatorcontrib>Yu, Haiyi</creatorcontrib><creatorcontrib>Feng, Jieli</creatorcontrib><creatorcontrib>Gao, Wei</creatorcontrib><creatorcontrib>Li, Lei</creatorcontrib><title>Increased hemoglobin A1c level associates with low left atrial appendage flow velocity in patients of atrial fibrillation</title><title>Nutrition, metabolism, and cardiovascular diseases</title><description>High hemoglobin A1c (HbAlc) level is associated with increased cardiovascular disease risk and thromboembolic events [1]. The study sought to explored the association between HbAlc and left atrial appendage flow velocity (LAAV) among non-valvular atrial fibrillation (AF) patients. A total of 249 consecutive non-valvular AF patients who underwent transesophageal echocardiography (TEE) were divided into two subgroups according to the median of LAAV level (&lt;45 cm/s, ≥45 cm/s). Blood samples and other baseline clinical data of all patients were collected and analyzed. The low LAAV group included 126 patients and the high LAAV group included 123 patients. Patients in the low LAAV group were older and had a higher percentage of persistent AF, chronic heart failure, and higher CHA2DS2-VASc score (P &lt; 0.05). HbAlc level in the low LAAV group was significantly higher than the high LAAV group [6.1 (5.7–6.5)% vs 5.9 (5.6–6.2)%, P = 0.010]. The low LAAV group had larger left atrial diameter (LAD), left atrial area (LAA), higher left atrial pressure (LAP), and lower left ventricular ejection fraction (LVEF) (P &lt; 0.05). Spearman rank correlation analysis showed that the HbAlc level was negatively correlated with LAAV (r = −0.211, P = 0.001). Multivariate analysis indicated that female gender (OR = 2.233, 95% CI 1.110–4.492, P = 0.024), persistent AF (OR = 6.610, 95% CI 3.109–14.052, P &lt; 0.001), and HbAlc (OR = 1.903, 95% CI 1.092–3.317, P = 0.023) were independent factors that associated with low LAAV in AF patients. Increased HbAlc level is associated with decreased LAAV and may reflect a low contractile function of the left atrial appendage. •Increased HbAlc level is associated with decreased LAAV in AF patients.•HbAlc level may reflect a low contractile function of the left atrial appendage.•Improving glycemic control may be helpful in reducing the risk of thrombus events in AF patients.</description><subject>Atrial fibrillation</subject><subject>Hemoglobin A1c</subject><subject>Left atrial appendage flow velocity</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kLtOwzAUhi0EEqXwBgweWRKOEydOFqSq4iZVYoHZcpzj1lUaB9sF9e1xVViZzvBf9J-PkFsGOQNW32_zcb9D3ecFFCwHkUPBz8iMVS1kpSjaczKDtmwzLqryklyFsAUoBZR8Rg6vo_aoAvZ0gzu3HlxnR7pgmg74hQNVIThtVcRAv23c0MF9J8VEqqK3KunThGOv1kjNUUqRZI8HmkomFS2OMVBn_tzGdt4OQxLceE0ujBoC3vzeOfl4enxfvmSrt-fX5WKV6bKpYtZ2aWrLuIBGdx3rWGNa6OtaAes5lgXWrNUCO2M49kaDAF41gjW1EUpVUJVzcnfqnbz73GOIcmeDxrRiRLcPsqiaBIc3VZ2s_GTV3oXg0cjJ253yB8lAHknLrTyRlkfSEoRMpFPs4RTD9MaXRS-DTp9r7K1HHWXv7P8FPyBnixg</recordid><startdate>20211028</startdate><enddate>20211028</enddate><creator>Wei, Ying</creator><creator>Cui, Ming</creator><creator>Liu, Shuwang</creator><creator>Yu, Haiyi</creator><creator>Feng, Jieli</creator><creator>Gao, Wei</creator><creator>Li, Lei</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7627-1945</orcidid></search><sort><creationdate>20211028</creationdate><title>Increased hemoglobin A1c level associates with low left atrial appendage flow velocity in patients of atrial fibrillation</title><author>Wei, Ying ; Cui, Ming ; Liu, Shuwang ; Yu, Haiyi ; Feng, Jieli ; Gao, Wei ; Li, Lei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-9b037914708cbb1b18f90d66a01d4e32e619c7ebff4edfc0704587186f7aa5053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Atrial fibrillation</topic><topic>Hemoglobin A1c</topic><topic>Left atrial appendage flow velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Ying</creatorcontrib><creatorcontrib>Cui, Ming</creatorcontrib><creatorcontrib>Liu, Shuwang</creatorcontrib><creatorcontrib>Yu, Haiyi</creatorcontrib><creatorcontrib>Feng, Jieli</creatorcontrib><creatorcontrib>Gao, Wei</creatorcontrib><creatorcontrib>Li, Lei</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Ying</au><au>Cui, Ming</au><au>Liu, Shuwang</au><au>Yu, Haiyi</au><au>Feng, Jieli</au><au>Gao, Wei</au><au>Li, Lei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased hemoglobin A1c level associates with low left atrial appendage flow velocity in patients of atrial fibrillation</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><date>2021-10-28</date><risdate>2021</risdate><volume>31</volume><issue>11</issue><spage>3176</spage><epage>3183</epage><pages>3176-3183</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>High hemoglobin A1c (HbAlc) level is associated with increased cardiovascular disease risk and thromboembolic events [1]. The study sought to explored the association between HbAlc and left atrial appendage flow velocity (LAAV) among non-valvular atrial fibrillation (AF) patients. A total of 249 consecutive non-valvular AF patients who underwent transesophageal echocardiography (TEE) were divided into two subgroups according to the median of LAAV level (&lt;45 cm/s, ≥45 cm/s). Blood samples and other baseline clinical data of all patients were collected and analyzed. The low LAAV group included 126 patients and the high LAAV group included 123 patients. Patients in the low LAAV group were older and had a higher percentage of persistent AF, chronic heart failure, and higher CHA2DS2-VASc score (P &lt; 0.05). HbAlc level in the low LAAV group was significantly higher than the high LAAV group [6.1 (5.7–6.5)% vs 5.9 (5.6–6.2)%, P = 0.010]. The low LAAV group had larger left atrial diameter (LAD), left atrial area (LAA), higher left atrial pressure (LAP), and lower left ventricular ejection fraction (LVEF) (P &lt; 0.05). Spearman rank correlation analysis showed that the HbAlc level was negatively correlated with LAAV (r = −0.211, P = 0.001). Multivariate analysis indicated that female gender (OR = 2.233, 95% CI 1.110–4.492, P = 0.024), persistent AF (OR = 6.610, 95% CI 3.109–14.052, P &lt; 0.001), and HbAlc (OR = 1.903, 95% CI 1.092–3.317, P = 0.023) were independent factors that associated with low LAAV in AF patients. Increased HbAlc level is associated with decreased LAAV and may reflect a low contractile function of the left atrial appendage. •Increased HbAlc level is associated with decreased LAAV in AF patients.•HbAlc level may reflect a low contractile function of the left atrial appendage.•Improving glycemic control may be helpful in reducing the risk of thrombus events in AF patients.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.numecd.2021.07.024</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7627-1945</orcidid><oa>free_for_read</oa></addata></record>
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subjects Atrial fibrillation
Hemoglobin A1c
Left atrial appendage flow velocity
title Increased hemoglobin A1c level associates with low left atrial appendage flow velocity in patients of atrial fibrillation
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