Effects of Dexmedetomidine and Oxycodone on Neurocognitive and Inflammatory Response After Tourniquet-Induced Ischemia–Reperfusion Injury

To evaluate the effects of dexmedetomidine (Dex) and oxycodone (Oxy) on neurocognitive and inflammatory response after tourniquet-induced ischemia–reperfusion (I/R) injury. C57/BL6 mice were used to construct the mouse model of tourniquet-induced I/R injury. Mice (n = 48) were randomly divided into...

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Veröffentlicht in:	Neurochemical research 2022-02, Vol.47 (2), p.461-469
Hauptverfasser:	Zhao, Shuang, Cheng, Wen-Jie, Liu, Xin, Li, Zhao, Li, Hui-Zhou, Shi, Na, Wang, Xiu-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cognition Dexmedetomidine - pharmacology Dexmedetomidine - therapeutic use Electrophysiology Hippocampus Inflammation Inflammatory response Injuries Interleukin 10 Ischemia Mice Microglia Neurochemistry Neurology Neurosciences NF-kappa B - metabolism NF-κB protein Original Paper Oxycodone Oxycodone - pharmacology Oxycodone - therapeutic use Phenotypes Polarization Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Spatial discrimination learning Spatial memory Synaptic transmission TLR4 protein Toll-like receptors Tourniquets Tumor necrosis factor-α
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