Polypeptides IGF-1C and P24 synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells in vitro through the p38 and JNK signaling pathways

Insulin-like growth factor-1 (IGF-1) and bone morphogenetic protein 2 (BMP-2) both promote osteogenesis of bone marrow mesenchymal stem cells (BMSCs). IGF-1C, the C domain peptide of IGF-1, and P24, a BMP-2-derived peptide, both have similar biological activities as their parent growth factors. This...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2021-12, Vol.141, p.106091, Article 106091
Hauptverfasser:	Ran, Gaoying, Fang, Wei, Zhang, Lifang, Peng, Yuting, Wu, Anbiao, Li, Jiatong, Ding, Xianglong, Zeng, Shuguang, He, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BMSCs Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Bone Morphogenetic Protein 2 - genetics Bone Morphogenetic Protein 2 - metabolism Cell Differentiation - drug effects Cell Proliferation - drug effects Cells, Cultured Growth factor Humans IGF-1C Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor I - pharmacology JNK MAP Kinase Signaling System - drug effects Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Osteogenesis Osteogenesis - drug effects P24 P38 p38 Mitogen-Activated Protein Kinases - metabolism Peptide Fragments - metabolism Peptide Fragments - pharmacology Peptides - metabolism Peptides - pharmacology Rats Rats, Sprague-Dawley
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