A lingering mouthwash with sustained antibiotic release and biofilm eradication for periodontitis

Dental plaque biofilms are believed to be one of the principal virulence factors in periodontitis resulting in tooth loss. Traditional mouthwashes are limited due to the continuous flow of saliva and poor drug penetration ability in the biofilm. Herein, we fabricated an antibiotic delivery platform...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2021-10, Vol.9 (41), p.8694-877
Hauptverfasser:	Li, Bohua, Shi, Liuqi, Liu, Ruixing, Li, Zhanrong, Cao, Shaokui, Li, Jingguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Biofilms Biofilms - drug effects Chitosan Chitosan - chemical synthesis Chitosan - chemistry Chitosan - pharmacology Continuous flow Controlled release Cyclodextrin Cyclodextrins Cyclodextrins - chemical synthesis Cyclodextrins - chemistry Cyclodextrins - pharmacology Dental plaque Dental Plaque - drug therapy Dental Plaque - microbiology Dental Plaque - pathology Drugs Infectious diseases Male Microbial Sensitivity Tests Minocycline Mouthwashes Mouthwashes - chemical synthesis Mouthwashes - chemistry Mouthwashes - pharmacology Penetration Periodontitis Periodontitis - drug therapy Periodontitis - microbiology Periodontitis - pathology Polysaccharides Porphyromonas gingivalis - drug effects Rats Rats, Sprague-Dawley Saccharides Saliva Sustained release Teeth Virulence Virulence factors
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