The resilient phenotype elicited by ketamine against inflammatory stressors-induced depressive-like behavior is associated with NLRP3-driven signaling pathway

Ketamine has emerged as a prophylactic agent against depressive-like behavior induced by stress. However, the possible pro-resilience effects of ketamine against inflammatory stressors-induced depressive-like behavior and the signaling pathways associated with this response remain to be determined....

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Veröffentlicht in:	Journal of psychiatric research 2021-12, Vol.144, p.118-128
Hauptverfasser:	Camargo, Anderson, Dalmagro, Ana Paula, Wolin, Ingrid A.V., Kaster, Manuella P., Rodrigues, Ana Lúcia S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Depression Inflammasomes - metabolism Inflammasomes - pharmacology Ketamine Ketamine - pharmacology Lipopolysaccharides - toxicity LPS Mice NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Phenotype Prophylactic effect Resilience Signal Transduction TNF-α
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