A preliminary study investigating the detection of lymphovascular invasion in germ cell tumors of the testis with double staining for OCT4/CD34
Lymphovascular invasion (LVI) is a relevant prognostic factor in germ cell tumors of the testis (GCTT) and it has been included in the AJCC staging system. Nevertheless, its histological assessment is challenging, with low/moderate interobserver agreement also among expert uropathologists. Few studi...
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| Veröffentlicht in: | Pathology, research and practice research and practice, 2021-11, Vol.227, p.153637-153637, Article 153637 |
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| container_title | Pathology, research and practice |
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| creator | Ricci, Costantino Franceschini, Tania Giunchi, Francesca Borsato, Matteo Mollica, Veronica Massari, Francesco Fiorentino, Michelangelo |
| description | Lymphovascular invasion (LVI) is a relevant prognostic factor in germ cell tumors of the testis (GCTT) and it has been included in the AJCC staging system. Nevertheless, its histological assessment is challenging, with low/moderate interobserver agreement also among expert uropathologists. Few studies focused on the potential role of immunohistochemistry to solve this critical issue; as result, in current guidelines there is no indication for additional staining to detect this histological feature. In the present study, we investigated the detection of LVI invasion in a small cohort of GCTT with double staining for OCT4/CD34. Although our results need to be validated in larger case series with follow-up data, they suggest as OCT4/CD34 could be a useful tool for the histological assessment of these tumors, helping to identify some histological mimickers of LVI and modifying the pT/stage in a significant percentage of patients. |
| doi_str_mv | 10.1016/j.prp.2021.153637 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-153259bc9b0352e62d47d50c4c95767959ce9f46e6ca80b0f6dfa1827ea3bfbf3</citedby><cites>FETCH-LOGICAL-c353t-153259bc9b0352e62d47d50c4c95767959ce9f46e6ca80b0f6dfa1827ea3bfbf3</cites><orcidid>0000-0001-7254-4195 ; 0000-0001-6476-6871</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0344033821002983$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34619577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ricci, Costantino</creatorcontrib><creatorcontrib>Franceschini, Tania</creatorcontrib><creatorcontrib>Giunchi, Francesca</creatorcontrib><creatorcontrib>Borsato, Matteo</creatorcontrib><creatorcontrib>Mollica, Veronica</creatorcontrib><creatorcontrib>Massari, Francesco</creatorcontrib><creatorcontrib>Fiorentino, Michelangelo</creatorcontrib><title>A preliminary study investigating the detection of lymphovascular invasion in germ cell tumors of the testis with double staining for OCT4/CD34</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>Lymphovascular invasion (LVI) is a relevant prognostic factor in germ cell tumors of the testis (GCTT) and it has been included in the AJCC staging system. Nevertheless, its histological assessment is challenging, with low/moderate interobserver agreement also among expert uropathologists. Few studies focused on the potential role of immunohistochemistry to solve this critical issue; as result, in current guidelines there is no indication for additional staining to detect this histological feature. In the present study, we investigated the detection of LVI invasion in a small cohort of GCTT with double staining for OCT4/CD34. 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Franceschini, Tania ; Giunchi, Francesca ; Borsato, Matteo ; Mollica, Veronica ; Massari, Francesco ; Fiorentino, Michelangelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-153259bc9b0352e62d47d50c4c95767959ce9f46e6ca80b0f6dfa1827ea3bfbf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Antigens, CD34 - analysis</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Embryonal - chemistry</topic><topic>Carcinoma, Embryonal - pathology</topic><topic>Double staining</topic><topic>Germ cell tumors of the testis</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Vessels - chemistry</topic><topic>Lymphatic Vessels - pathology</topic><topic>Lymphovascular invasion</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Complex and Mixed - chemistry</topic><topic>Neoplasms, Complex and Mixed - pathology</topic><topic>Neoplasms, Germ Cell and Embryonal - chemistry</topic><topic>Neoplasms, Germ Cell and Embryonal - pathology</topic><topic>OCT4</topic><topic>Octamer Transcription Factor-3 - analysis</topic><topic>Predictive Value of Tests</topic><topic>Retrospective Studies</topic><topic>Seminoma - chemistry</topic><topic>Seminoma - pathology</topic><topic>Staging</topic><topic>Testicular Neoplasms - chemistry</topic><topic>Testicular Neoplasms - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ricci, Costantino</creatorcontrib><creatorcontrib>Franceschini, Tania</creatorcontrib><creatorcontrib>Giunchi, Francesca</creatorcontrib><creatorcontrib>Borsato, Matteo</creatorcontrib><creatorcontrib>Mollica, Veronica</creatorcontrib><creatorcontrib>Massari, Francesco</creatorcontrib><creatorcontrib>Fiorentino, Michelangelo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ricci, Costantino</au><au>Franceschini, Tania</au><au>Giunchi, Francesca</au><au>Borsato, Matteo</au><au>Mollica, Veronica</au><au>Massari, Francesco</au><au>Fiorentino, Michelangelo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A preliminary study investigating the detection of lymphovascular invasion in germ cell tumors of the testis with double staining for OCT4/CD34</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2021-11</date><risdate>2021</risdate><volume>227</volume><spage>153637</spage><epage>153637</epage><pages>153637-153637</pages><artnum>153637</artnum><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>Lymphovascular invasion (LVI) is a relevant prognostic factor in germ cell tumors of the testis (GCTT) and it has been included in the AJCC staging system. Nevertheless, its histological assessment is challenging, with low/moderate interobserver agreement also among expert uropathologists. Few studies focused on the potential role of immunohistochemistry to solve this critical issue; as result, in current guidelines there is no indication for additional staining to detect this histological feature. In the present study, we investigated the detection of LVI invasion in a small cohort of GCTT with double staining for OCT4/CD34. Although our results need to be validated in larger case series with follow-up data, they suggest as OCT4/CD34 could be a useful tool for the histological assessment of these tumors, helping to identify some histological mimickers of LVI and modifying the pT/stage in a significant percentage of patients.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>34619577</pmid><doi>10.1016/j.prp.2021.153637</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7254-4195</orcidid><orcidid>https://orcid.org/0000-0001-6476-6871</orcidid></addata></record> |
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| subjects | Adult Antigens, CD34 - analysis Biomarkers, Tumor - analysis Carcinoma, Embryonal - chemistry Carcinoma, Embryonal - pathology Double staining Germ cell tumors of the testis Humans Immunohistochemistry Lymphatic Vessels - chemistry Lymphatic Vessels - pathology Lymphovascular invasion Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Neoplasms, Complex and Mixed - chemistry Neoplasms, Complex and Mixed - pathology Neoplasms, Germ Cell and Embryonal - chemistry Neoplasms, Germ Cell and Embryonal - pathology OCT4 Octamer Transcription Factor-3 - analysis Predictive Value of Tests Retrospective Studies Seminoma - chemistry Seminoma - pathology Staging Testicular Neoplasms - chemistry Testicular Neoplasms - pathology Young Adult |
| title | A preliminary study investigating the detection of lymphovascular invasion in germ cell tumors of the testis with double staining for OCT4/CD34 |
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