NIR irradiation-controlled drug release utilizing injectable hydrogels containing gold-labeled liposomes for the treatment of melanoma cancer

Drug-based chemotherapy is associated with serious side effects. We developed a chemotherapeutic system comprising a chitosan hydrogel (CH-HG) containing gold cluster-labeled liposomal doxorubicin (DOX) (CH-HG-GLDOX) as an injectable drug depot system. CH-HG-GLDOX can be directly injected into tumor...

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Veröffentlicht in:	Acta biomaterialia 2021-12, Vol.136, p.508-518
Hauptverfasser:	Won, Ji Eun, Wi, Tae In, Lee, Chan Mi, Lee, Ju Hyeong, Kang, Tae Heung, Lee, Jeong-Won, Shin, Byung Cheol, Lee, YeongJoo, Park, Yeong-Min, Han, Hee Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cancer vaccines CD8 antigen Cell Line, Tumor Chemotherapy Chitosan Clusters Combined vaccines Controlled release Cytotoxicity Doxorubicin Doxorubicin - pharmacology Drug delivery Drug Delivery Systems Drug Liberation Glycolic acid Gold Humans Hydrogel Hydrogels I.R. radiation Immunotherapy Irradiation Liposome Liposomes Lymphocytes Lymphocytes T Melanoma Nanoparticles Nanotechnology Near infrared radiation Retention time Side effects Toxicity Tumors Vaccines
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