Stability assessment of FDA‐approved ramucirumab monoclonal antibody; validated SE‐HPLC method for degradation pattern evaluation

Ramucirumab (RAMU) is a recently US Food and Drug Administration‐approved monoclonal antibody that is included in various anticancer protocols. It has a structural complexity and high degradation risk that have a significant effect on its safety and effectiveness. The major aim of this work was to a...

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Veröffentlicht in:	Biomedical chromatography 2022-02, Vol.36 (2), p.e5258-n/a
Hauptverfasser:	Abdelghaffar, Sara Hesham, Hegazy, Maha Abdelmonem, Eltanany, Basma Mohamed
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Humanized - analysis Antibodies, Monoclonal, Humanized - chemistry bio‐therapeutics Chromatography, Gel - methods Chromatography, High Pressure Liquid - methods degradation pattern Humans Limit of Detection Linear Models Peptide Fragments - analysis Peptide Fragments - chemistry Protein Stability Ramucirumab Reproducibility of Results size exclusion chromatography stability
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