Angiotensin II receptor blocker irbesartan attenuates sleep apnea–induced cardiac apoptosis and enhances cardiac survival and Sirtuin 1 upregulation

Background The purpose of this study was to investigate whether or not angiotensin II type 1 receptor blocker irbesartan (ARB) with a partial agonist of PPAR-γ could protect against chronic nocturnal intermittent hypoxia (CIH)–induced cardiac Fas/FasL-mediated to mitochondria-mediated apoptosis. Met...

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Veröffentlicht in:	Sleep & breathing 2022-09, Vol.26 (3), p.1161-1172
Hauptverfasser:	Pai, Pei-Ying, Lin, Yi-Yuan, Yu, Shao-Hong, Lin, Ching-Yuang, Liou, Yi-Fan, Wu, Xu-Bo, Wong, James K. S., Huang, Chih-Yang, Lee, Shin-Da
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Angiotensin Angiotensin II Apnea Apoptosis Bcl-x protein Caspase-3 Caspase-8 Caspase-9 Cell death Dentistry Echocardiography FADD protein FasL protein Heart Hypoxia Insulin-like growth factor I Internal Medicine Medicine Medicine & Public Health Mitochondria Neurology Otorhinolaryngology Oxygen Pediatrics Peroxisome proliferator-activated receptors Pneumology/Respiratory System SIRT1 protein Sleep Sleep apnea Sleep Breathing Physiology and Disorders • Original Article Survival Up-regulation Ventricle Western blotting
Online-Zugang:	Volltext
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