Protective Effects of Inosine on Memory Consolidation in a Rat Model of Scopolamine-Induced Cognitive Impairment: Involvement of Cholinergic Signaling, Redox Status, and Ion Pump Activities

This study investigated the effects of inosine on memory acquisition and consolidation, cholinesterases activities, redox status and Na + , K + -ATPase activity in a rat model of scopolamine-induced cognitive impairment. Adult male rats were divided into four groups: control (saline), scopolamine (1...

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Veröffentlicht in:	Neurochemical research 2022-02, Vol.47 (2), p.446-460
Hauptverfasser:	Teixeira, Fernanda Cardoso, de Mattos, Bruna da Silveira, Mello, Julia Eisenhardt de, Cardoso, Juliane, Spohr, Luiza, Luduvico, Karina Pereira, Soares, Mayara Sandrielly Pereira, Carvalho, Fabiano Barbosa, Gutierres, Jessie Martins, Oliveira Campello Felix, Anelize de, Stefanello, Francieli Moro, Spanevello, Roselia Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Alzheimer's disease Animal cognition Animals Antioxidants Avoidance Biochemistry Biomedical and Life Sciences Biomedicine Catalase Cell Biology Cholinergic Agents - adverse effects Cholinergics Cognitive ability Cognitive Dysfunction Consolidation Drug therapy Impairment Inosine - adverse effects Ion Pumps - pharmacology Ion Pumps - therapeutic use Male Maze Learning Memory Memory Consolidation Memory Disorders - chemically induced Memory Disorders - drug therapy Memory Disorders - prevention & control Na+/K+-exchanging ATPase Neurochemistry Neurodegenerative diseases Neurology Neurosciences Original Paper Oxidation-Reduction Oxidative Stress Rats Rats, Wistar Reactive oxygen species Rodents Scopolamine Scopolamine - pharmacology Signaling Superoxide dismutase Thiobarbituric acid Training
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