Impact of diverticular disease on prostate cancer risk among hypertensive men
Introduction Prostate cancer (PCa) is a heterogenous disease with multiple etiological factors playing a role in its development. Recently, chronic and systemic inflammatory conditions such as inflammatory bowel disease were identified as key risk factors influencing its development. The study aimed...
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| Veröffentlicht in: | Prostate cancer and prostatic diseases 2022-04, Vol.25 (4), p.700-706 |
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| creator | Tomer, Nir Chakravarty, Dimple Ratnani, Parita Mohamed, Nihal E. Jambor, Ivan Dovey, Zachary Palese, Michael A. Tewari, Ashutosh K. |
| description | Introduction
Prostate cancer (PCa) is a heterogenous disease with multiple etiological factors playing a role in its development. Recently, chronic and systemic inflammatory conditions such as inflammatory bowel disease were identified as key risk factors influencing its development. The study aimed to evaluate the relationship between diverticular disease (DD) (local and acute inflammation) and PCa.
Methods
Hypertensive patients with DD and hypertensive controls were identified between 1995 and 2010 from the Statewide Planning and Research Cooperative System database. Cohorts were queried for PCa incidence through 2015. Univariable and multivariable logistic regression analyses were used for determining independent predictors of PCa diagnosis.
Results
A total of 51,353 patients with DD and 111,541 controls were identified. In all, 6.26% of DD developed PCa, and 3.71% of controls developed PCa (
p
|
| doi_str_mv | 10.1038/s41391-021-00454-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2580691879</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2740752844</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-778f994f6570f1af409c513792efc76f90369d18869b807bcf02f7fc24914df23</originalsourceid><addsrcrecordid>eNp9kUlLBDEQhYMoLqN_wIMEvHhprSyd5SjiBooXPYdMOhlbexmTbof590ZnVPDgoUiFfO9VkYfQIYFTAkydJU6YJgXQXMBLXiw20C7hUhSlALWZeybKQqqS7qC9lF4AQBMN22iHcUEJELqL7m_buXUD7gOu6ncfh9qNjY35krxNHvcdnsc-DXbw2NnO-YhjnV6xbftuhp-X8yzxXcpS3PpuH20F2yR_sD4n6Onq8vHiprh7uL69OL8rHAc2FFKqoDUPopQQiA0ctCsJk5r64KQIGpjQFVFK6KkCOXUBaJDBUa4JrwJlE3Sy8s27vY0-Daatk_NNYzvfj8nQUoHQREmd0eM_6Es_xi5vZ6gUXGmtFf2f4iBLqjjPFF1RLn9Jij6YeaxbG5eGgPmMxKwiMTkS8xWJWWTR0dp6nLa--pF8Z5ABtgJSfupmPv7O_sf2Ay8JlWY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2740752844</pqid></control><display><type>article</type><title>Impact of diverticular disease on prostate cancer risk among hypertensive men</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Tomer, Nir ; Chakravarty, Dimple ; Ratnani, Parita ; Mohamed, Nihal E. ; Jambor, Ivan ; Dovey, Zachary ; Palese, Michael A. ; Tewari, Ashutosh K.</creator><creatorcontrib>Tomer, Nir ; Chakravarty, Dimple ; Ratnani, Parita ; Mohamed, Nihal E. ; Jambor, Ivan ; Dovey, Zachary ; Palese, Michael A. ; Tewari, Ashutosh K.</creatorcontrib><description><![CDATA[Introduction
Prostate cancer (PCa) is a heterogenous disease with multiple etiological factors playing a role in its development. Recently, chronic and systemic inflammatory conditions such as inflammatory bowel disease were identified as key risk factors influencing its development. The study aimed to evaluate the relationship between diverticular disease (DD) (local and acute inflammation) and PCa.
Methods
Hypertensive patients with DD and hypertensive controls were identified between 1995 and 2010 from the Statewide Planning and Research Cooperative System database. Cohorts were queried for PCa incidence through 2015. Univariable and multivariable logistic regression analyses were used for determining independent predictors of PCa diagnosis.
Results
A total of 51,353 patients with DD and 111,541 controls were identified. In all, 6.26% of DD developed PCa, and 3.71% of controls developed PCa (
p
< 0.01). DD was a significant risk factor for PCa (OR: 1.27 CI: 1.19–1.34,
p
< 0.01). On subgroup analysis, the patients diagnosed with DD <50 years old had an OR of 3.39 for PCa (CI: 2.52–4.56,
p
< 0.01), age 50–59 had an OR of 2.12 (CI: 1.86–2.15,
p
< 0.01), and age 60–69 had an OR of 1.20 (CI: 1.10–1.31,
p
< 0.01). Finally, age and race stratification showed that white patients <50 had an OR of 2.56 (CI: 1.75–3.76,
p
< 0.01), while black patients <50 had an OR of 3.98 (CI: 2.61–6.07,
p
< 0.01). The trend in differing odds between these populations was the same for age groups 50–59 and 60–69.
Conclusion
Our analysis shows that DD is associated with diagnosis of PCa in hypertensive men. Importantly, the earlier the diagnosis of DD, the higher the odds for development of PCa, particularly in black men.]]></description><identifier>ISSN: 1365-7852</identifier><identifier>EISSN: 1476-5608</identifier><identifier>DOI: 10.1038/s41391-021-00454-w</identifier><identifier>PMID: 34621012</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/589/466 ; 692/699/67/589/466 ; Age ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Chronic Disease ; Diagnosis ; Diverticular Diseases ; Health risks ; Humans ; Hypertension ; Incidence ; Inflammatory bowel diseases ; Male ; Middle Aged ; Prostate cancer ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - etiology ; Regression analysis ; Reproductive Medicine ; Risk analysis ; Risk Factors ; Subgroups</subject><ispartof>Prostate cancer and prostatic diseases, 2022-04, Vol.25 (4), p.700-706</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-778f994f6570f1af409c513792efc76f90369d18869b807bcf02f7fc24914df23</citedby><cites>FETCH-LOGICAL-c403t-778f994f6570f1af409c513792efc76f90369d18869b807bcf02f7fc24914df23</cites><orcidid>0000-0002-3146-4524 ; 0000-0002-5021-4440 ; 0000-0003-0547-8452</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41391-021-00454-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41391-021-00454-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34621012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomer, Nir</creatorcontrib><creatorcontrib>Chakravarty, Dimple</creatorcontrib><creatorcontrib>Ratnani, Parita</creatorcontrib><creatorcontrib>Mohamed, Nihal E.</creatorcontrib><creatorcontrib>Jambor, Ivan</creatorcontrib><creatorcontrib>Dovey, Zachary</creatorcontrib><creatorcontrib>Palese, Michael A.</creatorcontrib><creatorcontrib>Tewari, Ashutosh K.</creatorcontrib><title>Impact of diverticular disease on prostate cancer risk among hypertensive men</title><title>Prostate cancer and prostatic diseases</title><addtitle>Prostate Cancer Prostatic Dis</addtitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><description><![CDATA[Introduction
Prostate cancer (PCa) is a heterogenous disease with multiple etiological factors playing a role in its development. Recently, chronic and systemic inflammatory conditions such as inflammatory bowel disease were identified as key risk factors influencing its development. The study aimed to evaluate the relationship between diverticular disease (DD) (local and acute inflammation) and PCa.
Methods
Hypertensive patients with DD and hypertensive controls were identified between 1995 and 2010 from the Statewide Planning and Research Cooperative System database. Cohorts were queried for PCa incidence through 2015. Univariable and multivariable logistic regression analyses were used for determining independent predictors of PCa diagnosis.
Results
A total of 51,353 patients with DD and 111,541 controls were identified. In all, 6.26% of DD developed PCa, and 3.71% of controls developed PCa (
p
< 0.01). DD was a significant risk factor for PCa (OR: 1.27 CI: 1.19–1.34,
p
< 0.01). On subgroup analysis, the patients diagnosed with DD <50 years old had an OR of 3.39 for PCa (CI: 2.52–4.56,
p
< 0.01), age 50–59 had an OR of 2.12 (CI: 1.86–2.15,
p
< 0.01), and age 60–69 had an OR of 1.20 (CI: 1.10–1.31,
p
< 0.01). Finally, age and race stratification showed that white patients <50 had an OR of 2.56 (CI: 1.75–3.76,
p
< 0.01), while black patients <50 had an OR of 3.98 (CI: 2.61–6.07,
p
< 0.01). The trend in differing odds between these populations was the same for age groups 50–59 and 60–69.
Conclusion
Our analysis shows that DD is associated with diagnosis of PCa in hypertensive men. Importantly, the earlier the diagnosis of DD, the higher the odds for development of PCa, particularly in black men.]]></description><subject>631/67/589/466</subject><subject>692/699/67/589/466</subject><subject>Age</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Chronic Disease</subject><subject>Diagnosis</subject><subject>Diverticular Diseases</subject><subject>Health risks</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Inflammatory bowel diseases</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - etiology</subject><subject>Regression analysis</subject><subject>Reproductive Medicine</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Subgroups</subject><issn>1365-7852</issn><issn>1476-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUlLBDEQhYMoLqN_wIMEvHhprSyd5SjiBooXPYdMOhlbexmTbof590ZnVPDgoUiFfO9VkYfQIYFTAkydJU6YJgXQXMBLXiw20C7hUhSlALWZeybKQqqS7qC9lF4AQBMN22iHcUEJELqL7m_buXUD7gOu6ncfh9qNjY35krxNHvcdnsc-DXbw2NnO-YhjnV6xbftuhp-X8yzxXcpS3PpuH20F2yR_sD4n6Onq8vHiprh7uL69OL8rHAc2FFKqoDUPopQQiA0ctCsJk5r64KQIGpjQFVFK6KkCOXUBaJDBUa4JrwJlE3Sy8s27vY0-Daatk_NNYzvfj8nQUoHQREmd0eM_6Es_xi5vZ6gUXGmtFf2f4iBLqjjPFF1RLn9Jij6YeaxbG5eGgPmMxKwiMTkS8xWJWWTR0dp6nLa--pF8Z5ABtgJSfupmPv7O_sf2Ay8JlWY</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Tomer, Nir</creator><creator>Chakravarty, Dimple</creator><creator>Ratnani, Parita</creator><creator>Mohamed, Nihal E.</creator><creator>Jambor, Ivan</creator><creator>Dovey, Zachary</creator><creator>Palese, Michael A.</creator><creator>Tewari, Ashutosh K.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3146-4524</orcidid><orcidid>https://orcid.org/0000-0002-5021-4440</orcidid><orcidid>https://orcid.org/0000-0003-0547-8452</orcidid></search><sort><creationdate>20220401</creationdate><title>Impact of diverticular disease on prostate cancer risk among hypertensive men</title><author>Tomer, Nir ; Chakravarty, Dimple ; Ratnani, Parita ; Mohamed, Nihal E. ; Jambor, Ivan ; Dovey, Zachary ; Palese, Michael A. ; Tewari, Ashutosh K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-778f994f6570f1af409c513792efc76f90369d18869b807bcf02f7fc24914df23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>631/67/589/466</topic><topic>692/699/67/589/466</topic><topic>Age</topic><topic>Aged</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Chronic Disease</topic><topic>Diagnosis</topic><topic>Diverticular Diseases</topic><topic>Health risks</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Incidence</topic><topic>Inflammatory bowel diseases</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Prostatic Neoplasms - etiology</topic><topic>Regression analysis</topic><topic>Reproductive Medicine</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Subgroups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomer, Nir</creatorcontrib><creatorcontrib>Chakravarty, Dimple</creatorcontrib><creatorcontrib>Ratnani, Parita</creatorcontrib><creatorcontrib>Mohamed, Nihal E.</creatorcontrib><creatorcontrib>Jambor, Ivan</creatorcontrib><creatorcontrib>Dovey, Zachary</creatorcontrib><creatorcontrib>Palese, Michael A.</creatorcontrib><creatorcontrib>Tewari, Ashutosh K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Prostate cancer and prostatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomer, Nir</au><au>Chakravarty, Dimple</au><au>Ratnani, Parita</au><au>Mohamed, Nihal E.</au><au>Jambor, Ivan</au><au>Dovey, Zachary</au><au>Palese, Michael A.</au><au>Tewari, Ashutosh K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of diverticular disease on prostate cancer risk among hypertensive men</atitle><jtitle>Prostate cancer and prostatic diseases</jtitle><stitle>Prostate Cancer Prostatic Dis</stitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>25</volume><issue>4</issue><spage>700</spage><epage>706</epage><pages>700-706</pages><issn>1365-7852</issn><eissn>1476-5608</eissn><abstract><![CDATA[Introduction
Prostate cancer (PCa) is a heterogenous disease with multiple etiological factors playing a role in its development. Recently, chronic and systemic inflammatory conditions such as inflammatory bowel disease were identified as key risk factors influencing its development. The study aimed to evaluate the relationship between diverticular disease (DD) (local and acute inflammation) and PCa.
Methods
Hypertensive patients with DD and hypertensive controls were identified between 1995 and 2010 from the Statewide Planning and Research Cooperative System database. Cohorts were queried for PCa incidence through 2015. Univariable and multivariable logistic regression analyses were used for determining independent predictors of PCa diagnosis.
Results
A total of 51,353 patients with DD and 111,541 controls were identified. In all, 6.26% of DD developed PCa, and 3.71% of controls developed PCa (
p
< 0.01). DD was a significant risk factor for PCa (OR: 1.27 CI: 1.19–1.34,
p
< 0.01). On subgroup analysis, the patients diagnosed with DD <50 years old had an OR of 3.39 for PCa (CI: 2.52–4.56,
p
< 0.01), age 50–59 had an OR of 2.12 (CI: 1.86–2.15,
p
< 0.01), and age 60–69 had an OR of 1.20 (CI: 1.10–1.31,
p
< 0.01). Finally, age and race stratification showed that white patients <50 had an OR of 2.56 (CI: 1.75–3.76,
p
< 0.01), while black patients <50 had an OR of 3.98 (CI: 2.61–6.07,
p
< 0.01). The trend in differing odds between these populations was the same for age groups 50–59 and 60–69.
Conclusion
Our analysis shows that DD is associated with diagnosis of PCa in hypertensive men. Importantly, the earlier the diagnosis of DD, the higher the odds for development of PCa, particularly in black men.]]></abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34621012</pmid><doi>10.1038/s41391-021-00454-w</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3146-4524</orcidid><orcidid>https://orcid.org/0000-0002-5021-4440</orcidid><orcidid>https://orcid.org/0000-0003-0547-8452</orcidid></addata></record> |
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| ispartof | Prostate cancer and prostatic diseases, 2022-04, Vol.25 (4), p.700-706 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | 631/67/589/466 692/699/67/589/466 Age Aged Biomedical and Life Sciences Biomedicine Cancer Research Chronic Disease Diagnosis Diverticular Diseases Health risks Humans Hypertension Incidence Inflammatory bowel diseases Male Middle Aged Prostate cancer Prostatic Neoplasms - epidemiology Prostatic Neoplasms - etiology Regression analysis Reproductive Medicine Risk analysis Risk Factors Subgroups |
| title | Impact of diverticular disease on prostate cancer risk among hypertensive men |
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