A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress–induced depressive-like behavior in mice by regulating gut microbiota and metabolites

Major depressive disorder (MDD) is a neurasthenic disease, which is the second-largest burden of disease globally. Increasing studies have revealed that depression is associated with abnormalities in gut microbiota and metabolites. Several species of bacteria have been classified as psychobiotics, w...

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Veröffentlicht in:	Applied microbiology and biotechnology 2021-11, Vol.105 (21-22), p.8411-8426
Hauptverfasser:	Ding, Yang, Bu, Fan, Chen, Tuo, Shi, Guoping, Yuan, Xiaomin, Feng, Zeyu, Duan, Zhenglan, Wang, Rong, Zhang, Sumin, Wang, Qiong, Zhou, Jinyong, Chen, Yugen
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Akkermansia muciniphila Anaerobic bacteria Analysis Antidepressants Applied Microbial and Cell Physiology Biomarkers Biomedical and Life Sciences Biotechnology Brain-derived neurotrophic factor Cecum Correlation coefficient Correlation coefficients Corticosterone Depression, Mental Dopamine Gene sequencing Genetic aspects Histidine Identification and classification Intestinal microflora Life Sciences Mental depression Mental health Metabolites Metabolomics Methods Microbial Genetics and Genomics Microbiology Microbiota Microbiota (Symbiotic organisms) Microorganisms Neurotransmitters Phenotypes Probiotics RNA sequencing rRNA 16S Signs and symptoms Stress
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