Evaluation of the use of ketoprofen for the treatment of digital dermatitis in dairy cattle: A randomised, positive controlled, clinical trial
Background The objective of this study was to evaluate the benefits of administering ketoprofen to cows suffering from active digital dermatitis (DD). Methods 158 cows presented with active DD (M1, M2 or M4.1 stage) were randomly allocated to either the control or the treatment group. All cows were...
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| Veröffentlicht in: | Veterinary record 2022-03, Vol.190 (6), p.e977-n/a |
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| creator | Kasiora, Konstantina Anagnostopoulos, Alkiviadis Bedford, Cherril Menka, Theologia Barden, Matthew Griffiths, Bethany Eloise Achard, Damien Timms, Katherine Machado, Vinicius Silva Coates, Amy Oikonomou, Georgios |
| description | Background
The objective of this study was to evaluate the benefits of administering ketoprofen to cows suffering from active digital dermatitis (DD).
Methods
158 cows presented with active DD (M1, M2 or M4.1 stage) were randomly allocated to either the control or the treatment group. All cows were treated with topical application of oxytetracycline spray. The treatment group also received an intramuscular injection of ketoprofen (3 mg/kg, Ketofen 10%, Ceva Animal Health). Cows were mobility scored just before they were treated and then again one week later. Information regarding their daily milk production was also collected.
Results
Animals in the control group were at 2.57 (95% confidence interval (CI): 0.82–8.01, p = 0.10) times higher odds to be lame at the second evaluation compared to those that received ketoprofen as well. This was a numeric but not statistically significant difference. When only cows that were lame prior to treatment were considered, cows that did not receive ketoprofen were at 20.20 (95% CI: 1.40–291.29, p = 0.03) higher odds of remaining lame week post‐treatment comparing to cows that did receive ketoprofen. Freshly calved and lame at enrolment cows in the treatment group produced 58.38 ± 1.85 kg per day the week after treatment comparing to freshly calved and lame at enrolment controls that produced 47.89 ± 1.81 kg per day (p |
| doi_str_mv | 10.1002/vetr.977 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2580025125</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2640406469</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3837-d97e7dae10a941b809ddfc3cc5fc89e30dcc23e4aec374e2fa2e5233e9e66d9d3</originalsourceid><addsrcrecordid>eNp1kd9qHCEUh6W0NJu00CcIQm9ykUkcdca1dyFs_kAgENLeitEzrYmjW3U27Ev0meMkaQuFXnnwfH6c4w-hTy05agmhxxso6UgK8QYtKOG0Eb0gb9GCzDWXhOyg3ZzvKyk7Rt-jHcb7VlAhFujXaqP9pIuLAccBlx-Apwxz-QAlrlMcIOAhpudOSaDLCKHMfeu-u6I9tpDG-r64jF3AVru0xUaX4uELPsFJBxtHl8Ee4nXMFdsANjGUFL2fL413wZnqKclp_wG9G7TP8PH13ENfz1a3pxfN1fX55enJVWPYkonGSgHCamiJlry9WxJp7WCYMd1glhIYscZQBlyDYYIDHTSFjjIGEvreSsv20MGLt274c4JcVJ3RgPc6QJyyot2y_lbX0q6in_9B7-OUQp1O0Z4TTnrey79Ck2LOCQa1Tm7UaataouaM1JyRqhlVdP9VON2NYP-Av0OpQPMCPDoP2_-K1LfV7c0sfAJw7J5K</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2640406469</pqid></control><display><type>article</type><title>Evaluation of the use of ketoprofen for the treatment of digital dermatitis in dairy cattle: A randomised, positive controlled, clinical trial</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kasiora, Konstantina ; Anagnostopoulos, Alkiviadis ; Bedford, Cherril ; Menka, Theologia ; Barden, Matthew ; Griffiths, Bethany Eloise ; Achard, Damien ; Timms, Katherine ; Machado, Vinicius Silva ; Coates, Amy ; Oikonomou, Georgios</creator><creatorcontrib>Kasiora, Konstantina ; Anagnostopoulos, Alkiviadis ; Bedford, Cherril ; Menka, Theologia ; Barden, Matthew ; Griffiths, Bethany Eloise ; Achard, Damien ; Timms, Katherine ; Machado, Vinicius Silva ; Coates, Amy ; Oikonomou, Georgios</creatorcontrib><description>Background
The objective of this study was to evaluate the benefits of administering ketoprofen to cows suffering from active digital dermatitis (DD).
Methods
158 cows presented with active DD (M1, M2 or M4.1 stage) were randomly allocated to either the control or the treatment group. All cows were treated with topical application of oxytetracycline spray. The treatment group also received an intramuscular injection of ketoprofen (3 mg/kg, Ketofen 10%, Ceva Animal Health). Cows were mobility scored just before they were treated and then again one week later. Information regarding their daily milk production was also collected.
Results
Animals in the control group were at 2.57 (95% confidence interval (CI): 0.82–8.01, p = 0.10) times higher odds to be lame at the second evaluation compared to those that received ketoprofen as well. This was a numeric but not statistically significant difference. When only cows that were lame prior to treatment were considered, cows that did not receive ketoprofen were at 20.20 (95% CI: 1.40–291.29, p = 0.03) higher odds of remaining lame week post‐treatment comparing to cows that did receive ketoprofen. Freshly calved and lame at enrolment cows in the treatment group produced 58.38 ± 1.85 kg per day the week after treatment comparing to freshly calved and lame at enrolment controls that produced 47.89 ± 1.81 kg per day (p < 0.05).
Conclusion
The addition of ketoprofen in the treatment of active DD lesions may be beneficial for animal welfare and for animal productivity.</description><identifier>ISSN: 0042-4900</identifier><identifier>EISSN: 2042-7670</identifier><identifier>DOI: 10.1002/vetr.977</identifier><identifier>PMID: 34617277</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; Cattle ; Cattle Diseases - drug therapy ; Dermatitis ; Digital Dermatitis - drug therapy ; Female ; Ketoprofen - therapeutic use ; Lactation ; Lameness, Animal ; Veterinary medicine</subject><ispartof>Veterinary record, 2022-03, Vol.190 (6), p.e977-n/a</ispartof><rights>2021 The Authors. published by John Wiley & Sons Ltd on behalf of British Veterinary Association</rights><rights>2021 The Authors. Veterinary Record published by John Wiley & Sons Ltd on behalf of British Veterinary Association.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3837-d97e7dae10a941b809ddfc3cc5fc89e30dcc23e4aec374e2fa2e5233e9e66d9d3</citedby><cites>FETCH-LOGICAL-c3837-d97e7dae10a941b809ddfc3cc5fc89e30dcc23e4aec374e2fa2e5233e9e66d9d3</cites><orcidid>0000-0002-4451-4199</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fvetr.977$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fvetr.977$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34617277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasiora, Konstantina</creatorcontrib><creatorcontrib>Anagnostopoulos, Alkiviadis</creatorcontrib><creatorcontrib>Bedford, Cherril</creatorcontrib><creatorcontrib>Menka, Theologia</creatorcontrib><creatorcontrib>Barden, Matthew</creatorcontrib><creatorcontrib>Griffiths, Bethany Eloise</creatorcontrib><creatorcontrib>Achard, Damien</creatorcontrib><creatorcontrib>Timms, Katherine</creatorcontrib><creatorcontrib>Machado, Vinicius Silva</creatorcontrib><creatorcontrib>Coates, Amy</creatorcontrib><creatorcontrib>Oikonomou, Georgios</creatorcontrib><title>Evaluation of the use of ketoprofen for the treatment of digital dermatitis in dairy cattle: A randomised, positive controlled, clinical trial</title><title>Veterinary record</title><addtitle>Vet Rec</addtitle><description>Background
The objective of this study was to evaluate the benefits of administering ketoprofen to cows suffering from active digital dermatitis (DD).
Methods
158 cows presented with active DD (M1, M2 or M4.1 stage) were randomly allocated to either the control or the treatment group. All cows were treated with topical application of oxytetracycline spray. The treatment group also received an intramuscular injection of ketoprofen (3 mg/kg, Ketofen 10%, Ceva Animal Health). Cows were mobility scored just before they were treated and then again one week later. Information regarding their daily milk production was also collected.
Results
Animals in the control group were at 2.57 (95% confidence interval (CI): 0.82–8.01, p = 0.10) times higher odds to be lame at the second evaluation compared to those that received ketoprofen as well. This was a numeric but not statistically significant difference. When only cows that were lame prior to treatment were considered, cows that did not receive ketoprofen were at 20.20 (95% CI: 1.40–291.29, p = 0.03) higher odds of remaining lame week post‐treatment comparing to cows that did receive ketoprofen. Freshly calved and lame at enrolment cows in the treatment group produced 58.38 ± 1.85 kg per day the week after treatment comparing to freshly calved and lame at enrolment controls that produced 47.89 ± 1.81 kg per day (p < 0.05).
Conclusion
The addition of ketoprofen in the treatment of active DD lesions may be beneficial for animal welfare and for animal productivity.</description><subject>Animals</subject><subject>Cattle</subject><subject>Cattle Diseases - drug therapy</subject><subject>Dermatitis</subject><subject>Digital Dermatitis - drug therapy</subject><subject>Female</subject><subject>Ketoprofen - therapeutic use</subject><subject>Lactation</subject><subject>Lameness, Animal</subject><subject>Veterinary medicine</subject><issn>0042-4900</issn><issn>2042-7670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kd9qHCEUh6W0NJu00CcIQm9ykUkcdca1dyFs_kAgENLeitEzrYmjW3U27Ev0meMkaQuFXnnwfH6c4w-hTy05agmhxxso6UgK8QYtKOG0Eb0gb9GCzDWXhOyg3ZzvKyk7Rt-jHcb7VlAhFujXaqP9pIuLAccBlx-Apwxz-QAlrlMcIOAhpudOSaDLCKHMfeu-u6I9tpDG-r64jF3AVru0xUaX4uELPsFJBxtHl8Ee4nXMFdsANjGUFL2fL413wZnqKclp_wG9G7TP8PH13ENfz1a3pxfN1fX55enJVWPYkonGSgHCamiJlry9WxJp7WCYMd1glhIYscZQBlyDYYIDHTSFjjIGEvreSsv20MGLt274c4JcVJ3RgPc6QJyyot2y_lbX0q6in_9B7-OUQp1O0Z4TTnrey79Ck2LOCQa1Tm7UaataouaM1JyRqhlVdP9VON2NYP-Av0OpQPMCPDoP2_-K1LfV7c0sfAJw7J5K</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Kasiora, Konstantina</creator><creator>Anagnostopoulos, Alkiviadis</creator><creator>Bedford, Cherril</creator><creator>Menka, Theologia</creator><creator>Barden, Matthew</creator><creator>Griffiths, Bethany Eloise</creator><creator>Achard, Damien</creator><creator>Timms, Katherine</creator><creator>Machado, Vinicius Silva</creator><creator>Coates, Amy</creator><creator>Oikonomou, Georgios</creator><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4451-4199</orcidid></search><sort><creationdate>20220301</creationdate><title>Evaluation of the use of ketoprofen for the treatment of digital dermatitis in dairy cattle: A randomised, positive controlled, clinical trial</title><author>Kasiora, Konstantina ; Anagnostopoulos, Alkiviadis ; Bedford, Cherril ; Menka, Theologia ; Barden, Matthew ; Griffiths, Bethany Eloise ; Achard, Damien ; Timms, Katherine ; Machado, Vinicius Silva ; Coates, Amy ; Oikonomou, Georgios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3837-d97e7dae10a941b809ddfc3cc5fc89e30dcc23e4aec374e2fa2e5233e9e66d9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Cattle</topic><topic>Cattle Diseases - drug therapy</topic><topic>Dermatitis</topic><topic>Digital Dermatitis - drug therapy</topic><topic>Female</topic><topic>Ketoprofen - therapeutic use</topic><topic>Lactation</topic><topic>Lameness, Animal</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasiora, Konstantina</creatorcontrib><creatorcontrib>Anagnostopoulos, Alkiviadis</creatorcontrib><creatorcontrib>Bedford, Cherril</creatorcontrib><creatorcontrib>Menka, Theologia</creatorcontrib><creatorcontrib>Barden, Matthew</creatorcontrib><creatorcontrib>Griffiths, Bethany Eloise</creatorcontrib><creatorcontrib>Achard, Damien</creatorcontrib><creatorcontrib>Timms, Katherine</creatorcontrib><creatorcontrib>Machado, Vinicius Silva</creatorcontrib><creatorcontrib>Coates, Amy</creatorcontrib><creatorcontrib>Oikonomou, Georgios</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary record</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasiora, Konstantina</au><au>Anagnostopoulos, Alkiviadis</au><au>Bedford, Cherril</au><au>Menka, Theologia</au><au>Barden, Matthew</au><au>Griffiths, Bethany Eloise</au><au>Achard, Damien</au><au>Timms, Katherine</au><au>Machado, Vinicius Silva</au><au>Coates, Amy</au><au>Oikonomou, Georgios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the use of ketoprofen for the treatment of digital dermatitis in dairy cattle: A randomised, positive controlled, clinical trial</atitle><jtitle>Veterinary record</jtitle><addtitle>Vet Rec</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>190</volume><issue>6</issue><spage>e977</spage><epage>n/a</epage><pages>e977-n/a</pages><issn>0042-4900</issn><eissn>2042-7670</eissn><abstract>Background
The objective of this study was to evaluate the benefits of administering ketoprofen to cows suffering from active digital dermatitis (DD).
Methods
158 cows presented with active DD (M1, M2 or M4.1 stage) were randomly allocated to either the control or the treatment group. All cows were treated with topical application of oxytetracycline spray. The treatment group also received an intramuscular injection of ketoprofen (3 mg/kg, Ketofen 10%, Ceva Animal Health). Cows were mobility scored just before they were treated and then again one week later. Information regarding their daily milk production was also collected.
Results
Animals in the control group were at 2.57 (95% confidence interval (CI): 0.82–8.01, p = 0.10) times higher odds to be lame at the second evaluation compared to those that received ketoprofen as well. This was a numeric but not statistically significant difference. When only cows that were lame prior to treatment were considered, cows that did not receive ketoprofen were at 20.20 (95% CI: 1.40–291.29, p = 0.03) higher odds of remaining lame week post‐treatment comparing to cows that did receive ketoprofen. Freshly calved and lame at enrolment cows in the treatment group produced 58.38 ± 1.85 kg per day the week after treatment comparing to freshly calved and lame at enrolment controls that produced 47.89 ± 1.81 kg per day (p < 0.05).
Conclusion
The addition of ketoprofen in the treatment of active DD lesions may be beneficial for animal welfare and for animal productivity.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>34617277</pmid><doi>10.1002/vetr.977</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4451-4199</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0042-4900 |
| ispartof | Veterinary record, 2022-03, Vol.190 (6), p.e977-n/a |
| issn | 0042-4900 2042-7670 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Cattle Cattle Diseases - drug therapy Dermatitis Digital Dermatitis - drug therapy Female Ketoprofen - therapeutic use Lactation Lameness, Animal Veterinary medicine |
| title | Evaluation of the use of ketoprofen for the treatment of digital dermatitis in dairy cattle: A randomised, positive controlled, clinical trial |
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