Patterns of care and outcomes for gastric and gastro‐oesophageal junction cancer in an Australian population
Background A single state‐wide upper gastrointestinal (GI) cancer video‐linked multidisciplinary team (MDT) meeting guides management and evidence‐based care for all newly diagnosed upper GI cancer patients in South Australia. This study determined the patterns of care and outcomes for patients diag...
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| Veröffentlicht in: | ANZ journal of surgery 2021-12, Vol.91 (12), p.2675-2682 |
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| creator | Abbas, M Nazim Bright, Tim Price, Timothy Karapetis, Christos Thompson, Sarah Connell, Caroline Watson, David Barnes, Mary Bull, Jeff Singhal, Nimit Roy, Amitesh |
| description | Background
A single state‐wide upper gastrointestinal (GI) cancer video‐linked multidisciplinary team (MDT) meeting guides management and evidence‐based care for all newly diagnosed upper GI cancer patients in South Australia. This study determined the patterns of care and outcomes for patients diagnosed with gastric and gastro‐oesophageal junction (GOJ) cancers.
Methods
Patients diagnosed with gastric cancer and GOJ (Siewert III) cancer between June 2012 and June 2016 were included. Patient demographics, cancer stage, histology, diagnostic modalities and treatment data was analysed from a prospective database. Stage‐specific survival outcomes were determined and analysed for each treatment modality.
Results
The study included 218 patients and at diagnosis 132 (61%) patients had stage I–III and 86 (39%) patients had stage IV disease. One hundred and ninety‐five (89%) patients had gastric cancer and 23 (11%) had GOJ cancer (Siewert III). One hundred and nine (50%) patients underwent surgery, with 92% R0 resection rate. Forty‐six patients received perioperative chemotherapy and 111 (51%) patients received palliative intent treatment. Median overall survival for stage II, III and IV cancers was 57.6 (95% CI 57.6‐NR), 22.8 (95% CI 20.4–43.2), and 6.0 months (95% CI 4.8–8.4) respectively (p |
| doi_str_mv | 10.1111/ans.17249 |
| format | Article |
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A single state‐wide upper gastrointestinal (GI) cancer video‐linked multidisciplinary team (MDT) meeting guides management and evidence‐based care for all newly diagnosed upper GI cancer patients in South Australia. This study determined the patterns of care and outcomes for patients diagnosed with gastric and gastro‐oesophageal junction (GOJ) cancers.
Methods
Patients diagnosed with gastric cancer and GOJ (Siewert III) cancer between June 2012 and June 2016 were included. Patient demographics, cancer stage, histology, diagnostic modalities and treatment data was analysed from a prospective database. Stage‐specific survival outcomes were determined and analysed for each treatment modality.
Results
The study included 218 patients and at diagnosis 132 (61%) patients had stage I–III and 86 (39%) patients had stage IV disease. One hundred and ninety‐five (89%) patients had gastric cancer and 23 (11%) had GOJ cancer (Siewert III). One hundred and nine (50%) patients underwent surgery, with 92% R0 resection rate. Forty‐six patients received perioperative chemotherapy and 111 (51%) patients received palliative intent treatment. Median overall survival for stage II, III and IV cancers was 57.6 (95% CI 57.6‐NR), 22.8 (95% CI 20.4–43.2), and 6.0 months (95% CI 4.8–8.4) respectively (p < 0.001). Median overall survival for patients who underwent perioperative chemotherapy and surgery was not reached as compared to 44.4 months (95% CI 28.8‐NR) for patients who underwent surgery alone.
Conclusion
Treatment outcomes for patients with gastric and GOJ cancer managed across South Australia met contemporary evidence‐based practice. However, as most patients continue to present with late‐stage disease, longer‐term survival remains poor.
In South Australia a single state‐wide upper gastrointestinal (GI) cancer video linked multidisciplinary team (MDT) meeting guides management and evidence‐based care for all newly diagnosed upper GI cancer patients. We conducted a study to determine the patterns of care and outcomes for all patients diagnosed with gastric and gastro‐oesophageal junction (GOJ) cancers. We found that the outcomes in our population are comparable with the contemporary evidence‐based practice and despite the evolution of diagnostic and treatment modalities over the last few decades most of the patients present with late‐stage disease and their long‐term survival remains poor.</description><identifier>ISSN: 1445-1433</identifier><identifier>EISSN: 1445-2197</identifier><identifier>DOI: 10.1111/ans.17249</identifier><identifier>PMID: 34617383</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Australia - epidemiology ; Cancer ; Chemotherapy ; Demographics ; Demography ; Esophagogastric Junction ; Esophagus ; Gastric cancer ; Histology ; Humans ; Male ; multidisciplinary meeting ; Neoplasm Staging ; Patients ; patterns of care ; Stomach Neoplasms - epidemiology ; Stomach Neoplasms - therapy ; Surgery ; Survival ; Testicular Neoplasms</subject><ispartof>ANZ journal of surgery, 2021-12, Vol.91 (12), p.2675-2682</ispartof><rights>2021 Royal Australasian College of Surgeons.</rights><rights>2021 Royal Australasian College of Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-7e2ad76dea986cfc63ecf3d186938209d474e504bc957694eff4d400c2880fc93</citedby><cites>FETCH-LOGICAL-c3539-7e2ad76dea986cfc63ecf3d186938209d474e504bc957694eff4d400c2880fc93</cites><orcidid>0000-0002-1562-3708 ; 0000-0002-7683-2693</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fans.17249$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fans.17249$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34617383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abbas, M Nazim</creatorcontrib><creatorcontrib>Bright, Tim</creatorcontrib><creatorcontrib>Price, Timothy</creatorcontrib><creatorcontrib>Karapetis, Christos</creatorcontrib><creatorcontrib>Thompson, Sarah</creatorcontrib><creatorcontrib>Connell, Caroline</creatorcontrib><creatorcontrib>Watson, David</creatorcontrib><creatorcontrib>Barnes, Mary</creatorcontrib><creatorcontrib>Bull, Jeff</creatorcontrib><creatorcontrib>Singhal, Nimit</creatorcontrib><creatorcontrib>Roy, Amitesh</creatorcontrib><title>Patterns of care and outcomes for gastric and gastro‐oesophageal junction cancer in an Australian population</title><title>ANZ journal of surgery</title><addtitle>ANZ J Surg</addtitle><description>Background
A single state‐wide upper gastrointestinal (GI) cancer video‐linked multidisciplinary team (MDT) meeting guides management and evidence‐based care for all newly diagnosed upper GI cancer patients in South Australia. This study determined the patterns of care and outcomes for patients diagnosed with gastric and gastro‐oesophageal junction (GOJ) cancers.
Methods
Patients diagnosed with gastric cancer and GOJ (Siewert III) cancer between June 2012 and June 2016 were included. Patient demographics, cancer stage, histology, diagnostic modalities and treatment data was analysed from a prospective database. Stage‐specific survival outcomes were determined and analysed for each treatment modality.
Results
The study included 218 patients and at diagnosis 132 (61%) patients had stage I–III and 86 (39%) patients had stage IV disease. One hundred and ninety‐five (89%) patients had gastric cancer and 23 (11%) had GOJ cancer (Siewert III). One hundred and nine (50%) patients underwent surgery, with 92% R0 resection rate. Forty‐six patients received perioperative chemotherapy and 111 (51%) patients received palliative intent treatment. Median overall survival for stage II, III and IV cancers was 57.6 (95% CI 57.6‐NR), 22.8 (95% CI 20.4–43.2), and 6.0 months (95% CI 4.8–8.4) respectively (p < 0.001). Median overall survival for patients who underwent perioperative chemotherapy and surgery was not reached as compared to 44.4 months (95% CI 28.8‐NR) for patients who underwent surgery alone.
Conclusion
Treatment outcomes for patients with gastric and GOJ cancer managed across South Australia met contemporary evidence‐based practice. However, as most patients continue to present with late‐stage disease, longer‐term survival remains poor.
In South Australia a single state‐wide upper gastrointestinal (GI) cancer video linked multidisciplinary team (MDT) meeting guides management and evidence‐based care for all newly diagnosed upper GI cancer patients. We conducted a study to determine the patterns of care and outcomes for all patients diagnosed with gastric and gastro‐oesophageal junction (GOJ) cancers. We found that the outcomes in our population are comparable with the contemporary evidence‐based practice and despite the evolution of diagnostic and treatment modalities over the last few decades most of the patients present with late‐stage disease and their long‐term survival remains poor.</description><subject>Australia - epidemiology</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Demographics</subject><subject>Demography</subject><subject>Esophagogastric Junction</subject><subject>Esophagus</subject><subject>Gastric cancer</subject><subject>Histology</subject><subject>Humans</subject><subject>Male</subject><subject>multidisciplinary meeting</subject><subject>Neoplasm Staging</subject><subject>Patients</subject><subject>patterns of care</subject><subject>Stomach Neoplasms - epidemiology</subject><subject>Stomach Neoplasms - therapy</subject><subject>Surgery</subject><subject>Survival</subject><subject>Testicular Neoplasms</subject><issn>1445-1433</issn><issn>1445-2197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10ctKBSEYB3CJovuiFwihTS1OeRtnXB6iG0QF1VrM-aw5zNFJZ4h2PULP2JPkudQiyI0f-POP-Edoj5JjmteJ8emYlkyoFbRJhShGjKpydTlTwfkG2kppQgiVUhXraIMLSUte8U3k70zfQ_QJB4etiYCNr3EYehumkLALET-b1MfGzg_mc_j6-AyQQvdinsG0eDJ42zfB5_veQsSNzxaPh0xN2-SxC93QmhnZQWvOtAl2l_s2ejw_ezi9HF3fXlydjq9HlhdcjUpgpi5lDUZV0jorOVjHa1pJxStGVC1KAQURT1YVpVQCnBO1IMSyqiLOKr6NDhe5XQyvA6ReT5tkoW2NhzAkzYqKECYkmdGDP3QShujz6zSTlHBasIpmdbRQNoaUIjjdxWZq4rumRM9K0LkEPS8h2_1l4vA0hfpX_vx6BicL8Na08P5_kh7f3C8ivwH4kZJa</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Abbas, M Nazim</creator><creator>Bright, Tim</creator><creator>Price, Timothy</creator><creator>Karapetis, Christos</creator><creator>Thompson, Sarah</creator><creator>Connell, Caroline</creator><creator>Watson, David</creator><creator>Barnes, Mary</creator><creator>Bull, Jeff</creator><creator>Singhal, Nimit</creator><creator>Roy, Amitesh</creator><general>John Wiley & Sons Australia, Ltd</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1562-3708</orcidid><orcidid>https://orcid.org/0000-0002-7683-2693</orcidid></search><sort><creationdate>202112</creationdate><title>Patterns of care and outcomes for gastric and gastro‐oesophageal junction cancer in an Australian population</title><author>Abbas, M Nazim ; Bright, Tim ; Price, Timothy ; Karapetis, Christos ; Thompson, Sarah ; Connell, Caroline ; Watson, David ; Barnes, Mary ; Bull, Jeff ; Singhal, Nimit ; Roy, Amitesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-7e2ad76dea986cfc63ecf3d186938209d474e504bc957694eff4d400c2880fc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Australia - epidemiology</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Demographics</topic><topic>Demography</topic><topic>Esophagogastric Junction</topic><topic>Esophagus</topic><topic>Gastric cancer</topic><topic>Histology</topic><topic>Humans</topic><topic>Male</topic><topic>multidisciplinary meeting</topic><topic>Neoplasm Staging</topic><topic>Patients</topic><topic>patterns of care</topic><topic>Stomach Neoplasms - epidemiology</topic><topic>Stomach Neoplasms - therapy</topic><topic>Surgery</topic><topic>Survival</topic><topic>Testicular Neoplasms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abbas, M Nazim</creatorcontrib><creatorcontrib>Bright, Tim</creatorcontrib><creatorcontrib>Price, Timothy</creatorcontrib><creatorcontrib>Karapetis, Christos</creatorcontrib><creatorcontrib>Thompson, Sarah</creatorcontrib><creatorcontrib>Connell, Caroline</creatorcontrib><creatorcontrib>Watson, David</creatorcontrib><creatorcontrib>Barnes, Mary</creatorcontrib><creatorcontrib>Bull, Jeff</creatorcontrib><creatorcontrib>Singhal, Nimit</creatorcontrib><creatorcontrib>Roy, Amitesh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>ANZ journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abbas, M Nazim</au><au>Bright, Tim</au><au>Price, Timothy</au><au>Karapetis, Christos</au><au>Thompson, Sarah</au><au>Connell, Caroline</au><au>Watson, David</au><au>Barnes, Mary</au><au>Bull, Jeff</au><au>Singhal, Nimit</au><au>Roy, Amitesh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of care and outcomes for gastric and gastro‐oesophageal junction cancer in an Australian population</atitle><jtitle>ANZ journal of surgery</jtitle><addtitle>ANZ J Surg</addtitle><date>2021-12</date><risdate>2021</risdate><volume>91</volume><issue>12</issue><spage>2675</spage><epage>2682</epage><pages>2675-2682</pages><issn>1445-1433</issn><eissn>1445-2197</eissn><abstract>Background
A single state‐wide upper gastrointestinal (GI) cancer video‐linked multidisciplinary team (MDT) meeting guides management and evidence‐based care for all newly diagnosed upper GI cancer patients in South Australia. This study determined the patterns of care and outcomes for patients diagnosed with gastric and gastro‐oesophageal junction (GOJ) cancers.
Methods
Patients diagnosed with gastric cancer and GOJ (Siewert III) cancer between June 2012 and June 2016 were included. Patient demographics, cancer stage, histology, diagnostic modalities and treatment data was analysed from a prospective database. Stage‐specific survival outcomes were determined and analysed for each treatment modality.
Results
The study included 218 patients and at diagnosis 132 (61%) patients had stage I–III and 86 (39%) patients had stage IV disease. One hundred and ninety‐five (89%) patients had gastric cancer and 23 (11%) had GOJ cancer (Siewert III). One hundred and nine (50%) patients underwent surgery, with 92% R0 resection rate. Forty‐six patients received perioperative chemotherapy and 111 (51%) patients received palliative intent treatment. Median overall survival for stage II, III and IV cancers was 57.6 (95% CI 57.6‐NR), 22.8 (95% CI 20.4–43.2), and 6.0 months (95% CI 4.8–8.4) respectively (p < 0.001). Median overall survival for patients who underwent perioperative chemotherapy and surgery was not reached as compared to 44.4 months (95% CI 28.8‐NR) for patients who underwent surgery alone.
Conclusion
Treatment outcomes for patients with gastric and GOJ cancer managed across South Australia met contemporary evidence‐based practice. However, as most patients continue to present with late‐stage disease, longer‐term survival remains poor.
In South Australia a single state‐wide upper gastrointestinal (GI) cancer video linked multidisciplinary team (MDT) meeting guides management and evidence‐based care for all newly diagnosed upper GI cancer patients. We conducted a study to determine the patterns of care and outcomes for all patients diagnosed with gastric and gastro‐oesophageal junction (GOJ) cancers. We found that the outcomes in our population are comparable with the contemporary evidence‐based practice and despite the evolution of diagnostic and treatment modalities over the last few decades most of the patients present with late‐stage disease and their long‐term survival remains poor.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>34617383</pmid><doi>10.1111/ans.17249</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1562-3708</orcidid><orcidid>https://orcid.org/0000-0002-7683-2693</orcidid></addata></record> |
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| ispartof | ANZ journal of surgery, 2021-12, Vol.91 (12), p.2675-2682 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Australia - epidemiology Cancer Chemotherapy Demographics Demography Esophagogastric Junction Esophagus Gastric cancer Histology Humans Male multidisciplinary meeting Neoplasm Staging Patients patterns of care Stomach Neoplasms - epidemiology Stomach Neoplasms - therapy Surgery Survival Testicular Neoplasms |
| title | Patterns of care and outcomes for gastric and gastro‐oesophageal junction cancer in an Australian population |
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