The use of mice in diabetes research: The impact of physiological characteristics, choice of model and husbandry practices
Diabetes mellitus is characterised by hyperglycaemia, which results from an absolute or relative lack of insulin. Chronic and acute hyperglycaemia are associated with a range of health complications and an overall increased risk of mortality. Mouse models are vital in understanding the pathogenesis...
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| Veröffentlicht in: | Diabetic medicine 2021-12, Vol.38 (12), p.e14711-n/a |
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| container_title | Diabetic medicine |
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| creator | Daniels Gatward, Lydia F. Kennard, Matilda R. Smith, Lorna I. F. King, Aileen J. F. |
| description | Diabetes mellitus is characterised by hyperglycaemia, which results from an absolute or relative lack of insulin. Chronic and acute hyperglycaemia are associated with a range of health complications and an overall increased risk of mortality. Mouse models are vital in understanding the pathogenesis of this disease and its complications, as well as for developing new diabetes therapeutics. However, for experimental questions to be suitably tested, it is critical that factors inherent to the animal model are considered, as these can have profound impacts on experimental outcome, data reproducibility and robustness. In this review, we discuss key considerations relating to model choice, physiological characteristics (such as age, sex and genetic background) and husbandry practices and explore the impact of these on common experimental readouts used in preclinical diabetes research. |
| doi_str_mv | 10.1111/dme.14711 |
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| subjects | Animal husbandry Animal models Animals Biomedical Research - methods breeding Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - therapy Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - therapy Disease Management husbandry Hyperglycemia Insulin Insulin Resistance - physiology Medical research Mice mouse models physiological characteristics Physiology |
| title | The use of mice in diabetes research: The impact of physiological characteristics, choice of model and husbandry practices |
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