Disinfection of dentinal tubules with diclofenac sodium and N‐Acetylcysteine compared with calcium hydroxide as intracanal medicaments against Enterococcus faecalis
The purpose of this study was to evaluate the disinfection of dentinal tubules with diclofenac sodium (DS), N‐acetylcysteine (NAC) and calcium hydroxide (CH). Contaminated dentinal blocks were divided into two control and seven experimental groups (n = 15): CH, DS, NAC, CH + 5% DS, 50% CH + 50% DS,...
Gespeichert in:
| Veröffentlicht in: | Australian endodontic journal 2022-12, Vol.48 (3), p.386-391 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 391 |
|---|---|
| container_issue | 3 |
| container_start_page | 386 |
| container_title | Australian endodontic journal |
| container_volume | 48 |
| creator | Adl, Alireza Motamedifar, Mohammad Malekzadeh, Parastoo Sedigh‐Shams, Mahdi |
| description | The purpose of this study was to evaluate the disinfection of dentinal tubules with diclofenac sodium (DS), N‐acetylcysteine (NAC) and calcium hydroxide (CH). Contaminated dentinal blocks were divided into two control and seven experimental groups (n = 15): CH, DS, NAC, CH + 5% DS, 50% CH + 50% DS, CH + 5% NAC and 50% CH + 50% NAC. After seven days, dentine debris was obtained from two depths of 100 and 200 µm. The bacterial load was assessed by counting the number of colony‐forming units (CFUs). Pure DS exhibited maximum antibacterial activity at both depths. At 200 µm, it showed statistically significant differences with all the other groups (P 0.05). Pure DS was most effective in disinfecting dentinal tubules, and mixing CH with DS or NAC is not recommended. |
| doi_str_mv | 10.1111/aej.12575 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2580017678</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2580017678</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-b049f38029bc8aaf60dc1d6ae97961ca2b06c96f9268d47b472b440f9edb15773</originalsourceid><addsrcrecordid>eNp1kc9u1DAQhyMEoqVw4AWQJS5w2NZOHDs-rsryTxVc4BxN7DH1KrEX21GbG4_AU_BgPAleUjgg4cv48M03mvlV1VNGz1l5F4D7c1a3sr1XnTLJ5YZzKe-Xf1OrDVNcnlSPUtpTWvNGsofVScMFk4LT0-rHK5ect6izC54ESwz67DyMJM_DPGIiNy5fE-P0GCx60CQF4-aJgDfkw89v37ca8zLqJWV0HokO0wEimrVNw6iP8PViYrh1Bgkk4nyOoOE4Y8IihqmMTAS-gPMpk53PGIMOWs-JWMDicOlx9cDCmPDJXT2rPr_efbp8u7n6-Obd5fZqo5u2aTcD5co2Ha3VoDsAK6jRzAhAJZVgGuqBCq2EVbXoDJcDl_XAObUKzcBaKZuz6sXqPcTwdcaU-8kljeMIHsOc-rrtKC2nk11Bn_-D7sMcy1aFkrwTbdcpUaiXK6VjSCmi7Q_RTRCXntH-GF5fwut_h1fYZ3fGeSiX-Uv-SasAFytw40Zc_m_qt7v3q_IXGLen7w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2748658896</pqid></control><display><type>article</type><title>Disinfection of dentinal tubules with diclofenac sodium and N‐Acetylcysteine compared with calcium hydroxide as intracanal medicaments against Enterococcus faecalis</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Adl, Alireza ; Motamedifar, Mohammad ; Malekzadeh, Parastoo ; Sedigh‐Shams, Mahdi</creator><creatorcontrib>Adl, Alireza ; Motamedifar, Mohammad ; Malekzadeh, Parastoo ; Sedigh‐Shams, Mahdi</creatorcontrib><description>The purpose of this study was to evaluate the disinfection of dentinal tubules with diclofenac sodium (DS), N‐acetylcysteine (NAC) and calcium hydroxide (CH). Contaminated dentinal blocks were divided into two control and seven experimental groups (n = 15): CH, DS, NAC, CH + 5% DS, 50% CH + 50% DS, CH + 5% NAC and 50% CH + 50% NAC. After seven days, dentine debris was obtained from two depths of 100 and 200 µm. The bacterial load was assessed by counting the number of colony‐forming units (CFUs). Pure DS exhibited maximum antibacterial activity at both depths. At 200 µm, it showed statistically significant differences with all the other groups (P < 0.05). Mixing CH with either 5% or 50% of DS and NAC did not increase the antibacterial efficacy (P > 0.05). Pure DS was most effective in disinfecting dentinal tubules, and mixing CH with DS or NAC is not recommended.</description><identifier>ISSN: 1329-1947</identifier><identifier>EISSN: 1747-4477</identifier><identifier>DOI: 10.1111/aej.12575</identifier><identifier>PMID: 34617640</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Acetylcysteine ; Acetylcysteine - pharmacology ; Anti-Bacterial Agents - pharmacology ; Antibacterial activity ; Calcium hydroxide ; Calcium Hydroxide - pharmacology ; Dental Pulp Cavity - microbiology ; Dentin ; dentine ; Diclofenac ; Diclofenac - pharmacology ; diclofenac sodium ; Disinfection ; E. faecalis ; Enterococcus faecalis ; N‐acetylcysteine ; Root Canal Irrigants - pharmacology ; Statistical analysis ; Tubules</subject><ispartof>Australian endodontic journal, 2022-12, Vol.48 (3), p.386-391</ispartof><rights>2021 Australian Society of Endodontology Inc</rights><rights>2021 Australian Society of Endodontology Inc.</rights><rights>Copyright © 2022 Australian Society of Endodontology Inc</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-b049f38029bc8aaf60dc1d6ae97961ca2b06c96f9268d47b472b440f9edb15773</citedby><cites>FETCH-LOGICAL-c3535-b049f38029bc8aaf60dc1d6ae97961ca2b06c96f9268d47b472b440f9edb15773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faej.12575$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faej.12575$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27925,27926,45575,45576</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34617640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adl, Alireza</creatorcontrib><creatorcontrib>Motamedifar, Mohammad</creatorcontrib><creatorcontrib>Malekzadeh, Parastoo</creatorcontrib><creatorcontrib>Sedigh‐Shams, Mahdi</creatorcontrib><title>Disinfection of dentinal tubules with diclofenac sodium and N‐Acetylcysteine compared with calcium hydroxide as intracanal medicaments against Enterococcus faecalis</title><title>Australian endodontic journal</title><addtitle>Aust Endod J</addtitle><description>The purpose of this study was to evaluate the disinfection of dentinal tubules with diclofenac sodium (DS), N‐acetylcysteine (NAC) and calcium hydroxide (CH). Contaminated dentinal blocks were divided into two control and seven experimental groups (n = 15): CH, DS, NAC, CH + 5% DS, 50% CH + 50% DS, CH + 5% NAC and 50% CH + 50% NAC. After seven days, dentine debris was obtained from two depths of 100 and 200 µm. The bacterial load was assessed by counting the number of colony‐forming units (CFUs). Pure DS exhibited maximum antibacterial activity at both depths. At 200 µm, it showed statistically significant differences with all the other groups (P < 0.05). Mixing CH with either 5% or 50% of DS and NAC did not increase the antibacterial efficacy (P > 0.05). Pure DS was most effective in disinfecting dentinal tubules, and mixing CH with DS or NAC is not recommended.</description><subject>Acetylcysteine</subject><subject>Acetylcysteine - pharmacology</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Calcium hydroxide</subject><subject>Calcium Hydroxide - pharmacology</subject><subject>Dental Pulp Cavity - microbiology</subject><subject>Dentin</subject><subject>dentine</subject><subject>Diclofenac</subject><subject>Diclofenac - pharmacology</subject><subject>diclofenac sodium</subject><subject>Disinfection</subject><subject>E. faecalis</subject><subject>Enterococcus faecalis</subject><subject>N‐acetylcysteine</subject><subject>Root Canal Irrigants - pharmacology</subject><subject>Statistical analysis</subject><subject>Tubules</subject><issn>1329-1947</issn><issn>1747-4477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9u1DAQhyMEoqVw4AWQJS5w2NZOHDs-rsryTxVc4BxN7DH1KrEX21GbG4_AU_BgPAleUjgg4cv48M03mvlV1VNGz1l5F4D7c1a3sr1XnTLJ5YZzKe-Xf1OrDVNcnlSPUtpTWvNGsofVScMFk4LT0-rHK5ect6izC54ESwz67DyMJM_DPGIiNy5fE-P0GCx60CQF4-aJgDfkw89v37ca8zLqJWV0HokO0wEimrVNw6iP8PViYrh1Bgkk4nyOoOE4Y8IihqmMTAS-gPMpk53PGIMOWs-JWMDicOlx9cDCmPDJXT2rPr_efbp8u7n6-Obd5fZqo5u2aTcD5co2Ha3VoDsAK6jRzAhAJZVgGuqBCq2EVbXoDJcDl_XAObUKzcBaKZuz6sXqPcTwdcaU-8kljeMIHsOc-rrtKC2nk11Bn_-D7sMcy1aFkrwTbdcpUaiXK6VjSCmi7Q_RTRCXntH-GF5fwut_h1fYZ3fGeSiX-Uv-SasAFytw40Zc_m_qt7v3q_IXGLen7w</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Adl, Alireza</creator><creator>Motamedifar, Mohammad</creator><creator>Malekzadeh, Parastoo</creator><creator>Sedigh‐Shams, Mahdi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202212</creationdate><title>Disinfection of dentinal tubules with diclofenac sodium and N‐Acetylcysteine compared with calcium hydroxide as intracanal medicaments against Enterococcus faecalis</title><author>Adl, Alireza ; Motamedifar, Mohammad ; Malekzadeh, Parastoo ; Sedigh‐Shams, Mahdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-b049f38029bc8aaf60dc1d6ae97961ca2b06c96f9268d47b472b440f9edb15773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acetylcysteine</topic><topic>Acetylcysteine - pharmacology</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Calcium hydroxide</topic><topic>Calcium Hydroxide - pharmacology</topic><topic>Dental Pulp Cavity - microbiology</topic><topic>Dentin</topic><topic>dentine</topic><topic>Diclofenac</topic><topic>Diclofenac - pharmacology</topic><topic>diclofenac sodium</topic><topic>Disinfection</topic><topic>E. faecalis</topic><topic>Enterococcus faecalis</topic><topic>N‐acetylcysteine</topic><topic>Root Canal Irrigants - pharmacology</topic><topic>Statistical analysis</topic><topic>Tubules</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adl, Alireza</creatorcontrib><creatorcontrib>Motamedifar, Mohammad</creatorcontrib><creatorcontrib>Malekzadeh, Parastoo</creatorcontrib><creatorcontrib>Sedigh‐Shams, Mahdi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Australian endodontic journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adl, Alireza</au><au>Motamedifar, Mohammad</au><au>Malekzadeh, Parastoo</au><au>Sedigh‐Shams, Mahdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disinfection of dentinal tubules with diclofenac sodium and N‐Acetylcysteine compared with calcium hydroxide as intracanal medicaments against Enterococcus faecalis</atitle><jtitle>Australian endodontic journal</jtitle><addtitle>Aust Endod J</addtitle><date>2022-12</date><risdate>2022</risdate><volume>48</volume><issue>3</issue><spage>386</spage><epage>391</epage><pages>386-391</pages><issn>1329-1947</issn><eissn>1747-4477</eissn><abstract>The purpose of this study was to evaluate the disinfection of dentinal tubules with diclofenac sodium (DS), N‐acetylcysteine (NAC) and calcium hydroxide (CH). Contaminated dentinal blocks were divided into two control and seven experimental groups (n = 15): CH, DS, NAC, CH + 5% DS, 50% CH + 50% DS, CH + 5% NAC and 50% CH + 50% NAC. After seven days, dentine debris was obtained from two depths of 100 and 200 µm. The bacterial load was assessed by counting the number of colony‐forming units (CFUs). Pure DS exhibited maximum antibacterial activity at both depths. At 200 µm, it showed statistically significant differences with all the other groups (P < 0.05). Mixing CH with either 5% or 50% of DS and NAC did not increase the antibacterial efficacy (P > 0.05). Pure DS was most effective in disinfecting dentinal tubules, and mixing CH with DS or NAC is not recommended.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34617640</pmid><doi>10.1111/aej.12575</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1329-1947 |
| ispartof | Australian endodontic journal, 2022-12, Vol.48 (3), p.386-391 |
| issn | 1329-1947 1747-4477 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2580017678 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Acetylcysteine Acetylcysteine - pharmacology Anti-Bacterial Agents - pharmacology Antibacterial activity Calcium hydroxide Calcium Hydroxide - pharmacology Dental Pulp Cavity - microbiology Dentin dentine Diclofenac Diclofenac - pharmacology diclofenac sodium Disinfection E. faecalis Enterococcus faecalis N‐acetylcysteine Root Canal Irrigants - pharmacology Statistical analysis Tubules |
| title | Disinfection of dentinal tubules with diclofenac sodium and N‐Acetylcysteine compared with calcium hydroxide as intracanal medicaments against Enterococcus faecalis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T13%3A39%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Disinfection%20of%20dentinal%20tubules%20with%20diclofenac%20sodium%20and%20N%E2%80%90Acetylcysteine%20compared%20with%20calcium%20hydroxide%20as%20intracanal%20medicaments%20against%20Enterococcus%20faecalis&rft.jtitle=Australian%20endodontic%20journal&rft.au=Adl,%20Alireza&rft.date=2022-12&rft.volume=48&rft.issue=3&rft.spage=386&rft.epage=391&rft.pages=386-391&rft.issn=1329-1947&rft.eissn=1747-4477&rft_id=info:doi/10.1111/aej.12575&rft_dat=%3Cproquest_cross%3E2580017678%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2748658896&rft_id=info:pmid/34617640&rfr_iscdi=true |