Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV
We studied the effect of an experimental synthetic organoselenium compound 2,6-dipyridinium- 9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the cell composition of the red bone marrow and peripheral blood in white mice. The study drug co-administered with Yersinia pestis EV vaccine strain (103 CF...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2021-09, Vol.171 (5), p.651-655 |
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| creator | Dubrovina, V. I. Starovoitova, T. P. Yur’eva, O. V. Pyatidesyatnikova, A. B. Potapov, V. A. Musalov, M. V. Balakhonov, S. V. |
| description | We studied the effect of an experimental synthetic organoselenium compound 2,6-dipyridinium- 9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the cell composition of the red bone marrow and peripheral blood in white mice. The study drug co-administered with
Yersinia pestis
EV vaccine strain (103 CFU) potentiated maturation and migration of mature neutrophils from the bone marrow into the circulation. Reducing the dose of the live vaccine and the anti-inflammatory properties of the study drug made it possible to reduce the allergic reaction during the vaccination process. |
| doi_str_mv | 10.1007/s10517-021-05287-0 |
| format | Article |
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Yersinia pestis
EV vaccine strain (103 CFU) potentiated maturation and migration of mature neutrophils from the bone marrow into the circulation. Reducing the dose of the live vaccine and the anti-inflammatory properties of the study drug made it possible to reduce the allergic reaction during the vaccination process.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-021-05287-0</identifier><identifier>PMID: 34618261</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Animals, Outbred Strains ; Anti-inflammatory agents ; Biomedical and Life Sciences ; Biomedicine ; Blood Cell Count ; Blood Cells - drug effects ; Blood Cells - immunology ; Blood Cells - pathology ; Bone composition ; Bone marrow ; Bone Marrow - drug effects ; Bone Marrow - immunology ; Cell Biology ; Health aspects ; Hypersensitivity ; Immunization ; Inflammation ; Internal Medicine ; Laboratory Medicine ; Leukocyte migration ; Leukocytes (neutrophilic) ; Lymphopoiesis - drug effects ; Medical research ; Medicine, Experimental ; Mice ; Organoselenium Compounds - pharmacology ; Pathology ; Peripheral blood ; Vaccination ; Vaccines ; Vaccines, Attenuated - immunology ; Vaccines, Attenuated - pharmacology ; Vaccines, Attenuated - therapeutic use ; Yersinia pestis ; Yersinia pestis - immunology</subject><ispartof>Bulletin of experimental biology and medicine, 2021-09, Vol.171 (5), p.651-655</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-217285d0f34668c664967f1f247b3888f7981c3e9f09aff2b02d095a3649fcb03</citedby><cites>FETCH-LOGICAL-c473t-217285d0f34668c664967f1f247b3888f7981c3e9f09aff2b02d095a3649fcb03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-021-05287-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-021-05287-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34618261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dubrovina, V. I.</creatorcontrib><creatorcontrib>Starovoitova, T. P.</creatorcontrib><creatorcontrib>Yur’eva, O. V.</creatorcontrib><creatorcontrib>Pyatidesyatnikova, A. B.</creatorcontrib><creatorcontrib>Potapov, V. A.</creatorcontrib><creatorcontrib>Musalov, M. V.</creatorcontrib><creatorcontrib>Balakhonov, S. V.</creatorcontrib><title>Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We studied the effect of an experimental synthetic organoselenium compound 2,6-dipyridinium- 9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the cell composition of the red bone marrow and peripheral blood in white mice. The study drug co-administered with
Yersinia pestis
EV vaccine strain (103 CFU) potentiated maturation and migration of mature neutrophils from the bone marrow into the circulation. Reducing the dose of the live vaccine and the anti-inflammatory properties of the study drug made it possible to reduce the allergic reaction during the vaccination process.</description><subject>Animals</subject><subject>Animals, Outbred Strains</subject><subject>Anti-inflammatory agents</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Cell Count</subject><subject>Blood Cells - drug effects</subject><subject>Blood Cells - immunology</subject><subject>Blood Cells - pathology</subject><subject>Bone composition</subject><subject>Bone marrow</subject><subject>Bone Marrow - drug effects</subject><subject>Bone Marrow - immunology</subject><subject>Cell Biology</subject><subject>Health aspects</subject><subject>Hypersensitivity</subject><subject>Immunization</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Leukocyte migration</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphopoiesis - drug effects</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mice</subject><subject>Organoselenium Compounds - pharmacology</subject><subject>Pathology</subject><subject>Peripheral blood</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Vaccines, Attenuated - immunology</subject><subject>Vaccines, Attenuated - pharmacology</subject><subject>Vaccines, Attenuated - therapeutic use</subject><subject>Yersinia pestis</subject><subject>Yersinia pestis - immunology</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ks1u1TAQhSMEopfCC7BAlpAQmxTb-XGybK8uUKmoFT9FrCxfZ3zjKrFTO1HVt-PRmDQtpQihLJyMv3MmMzpJ8pLRA0apeBcZLZhIKWcpLXiFb4-SFStEllacs8fJiiKV5lVV7SXPYryYP2nJniZ7WV6yipdslfzcGAN6JN4QRb5cu7GF0WpyGnbK-QgdODv1ZO37wU-uId6RMx_H9FxpbZ0aLRaO-35yfvAWoo3EOoIe5DM05Mg7IJ9UCP6KKBSvoesWq2hvlNj0DIIdWgiqI0ed981c-97aEYVWA7nrg25XdmzJDwjROqvIAHHEbpvz58kTo7oIL27P_eTb-83X9cf05PTD8frwJNW5yMaUM8GroqEGRy8rXZZ5XQrDDM_FNsMNGVFXTGdQG1orY_iW8obWhcoQNHpLs_3k7eI7BH85YXfZ26hxIuXAT1HyoqKUiSLniL7-C73wU3D4dzPF6iIr8uye2qkOpHXGj0Hp2VQelsiIQrC57cE_KHwa6K3GBRuL9QeCN38IWlDd2EbfTfPC40OQL6AOPsYARg7B9ipcS0blnC-55EtivuRNvuQsenU72rTtofktuQsUAtkCRLxyOwj3s__H9hfN-NnD</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Dubrovina, V. 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I. ; Starovoitova, T. P. ; Yur’eva, O. V. ; Pyatidesyatnikova, A. B. ; Potapov, V. A. ; Musalov, M. V. ; Balakhonov, S. 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I.</creatorcontrib><creatorcontrib>Starovoitova, T. P.</creatorcontrib><creatorcontrib>Yur’eva, O. V.</creatorcontrib><creatorcontrib>Pyatidesyatnikova, A. B.</creatorcontrib><creatorcontrib>Potapov, V. A.</creatorcontrib><creatorcontrib>Musalov, M. V.</creatorcontrib><creatorcontrib>Balakhonov, S. 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The study drug co-administered with
Yersinia pestis
EV vaccine strain (103 CFU) potentiated maturation and migration of mature neutrophils from the bone marrow into the circulation. Reducing the dose of the live vaccine and the anti-inflammatory properties of the study drug made it possible to reduce the allergic reaction during the vaccination process.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34618261</pmid><doi>10.1007/s10517-021-05287-0</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Animals, Outbred Strains Anti-inflammatory agents Biomedical and Life Sciences Biomedicine Blood Cell Count Blood Cells - drug effects Blood Cells - immunology Blood Cells - pathology Bone composition Bone marrow Bone Marrow - drug effects Bone Marrow - immunology Cell Biology Health aspects Hypersensitivity Immunization Inflammation Internal Medicine Laboratory Medicine Leukocyte migration Leukocytes (neutrophilic) Lymphopoiesis - drug effects Medical research Medicine, Experimental Mice Organoselenium Compounds - pharmacology Pathology Peripheral blood Vaccination Vaccines Vaccines, Attenuated - immunology Vaccines, Attenuated - pharmacology Vaccines, Attenuated - therapeutic use Yersinia pestis Yersinia pestis - immunology |
| title | Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV |
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