High-Content Phenotypic Screen of a Focused TCAMS Drug Library Identifies Novel Disruptors of the Malaria Parasite Calcium Dynamics

The search for new antimalarial drugs with unexplored mechanisms of action is currently one of the main objectives to combat the resistance already in the clinic. New drugs should target specific mechanisms that once initiated lead inevitably to the parasite’s death and clearance and cause minimal t...

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Veröffentlicht in:	ACS chemical biology 2021-11, Vol.16 (11), p.2348-2372
Hauptverfasser:	Chia, Wanni, Gomez-Lorenzo, Maria G, Castellote, Isabel, Tong, Jie Xin, Chandramohanadas, Rajesh, Thu Chu, Trang Thi, Shen, Wanxiang, Go, Mei Lin, de Cozar, Cristina, Crespo, Benigno, Almela, Maria J, Neria-Serrano, Fernando, Franco, Virginia, Gamo, Francisco-Javier, Tan, Kevin S. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - chemistry Antimalarials - pharmacology Benzofurans - chemistry Calcium - metabolism Cytosol - metabolism DNA - metabolism High-Throughput Screening Assays - methods Homeostasis - drug effects Imidazoles - chemistry Mitochondria - metabolism Plasmodium falciparum - drug effects Plasmodium falciparum - metabolism Structure-Activity Relationship
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