Integrated lipidomics, transcriptomics and network pharmacology analysis to reveal the mechanisms of Danggui Buxue Decoction in the treatment of diabetic nephropathy in type 2 diabetes mellitus

Danggui Buxue Decoction (DBT) is classical prescriptions, which contains two Traditional Chinese Medicines of Angelicae sinensis radix and Astragali radix. According to the preliminary work of our laboratory and numerous studies, it has been found that DBT has a therapeutic effect on diabetic nephro...

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Veröffentlicht in:	Journal of ethnopharmacology 2022-01, Vol.283, p.114699-114699, Article 114699
Hauptverfasser:	Sun, Lili, Yang, Zhigang, Zhao, Wei, Chen, Qin, Bai, Haiying, Wang, Shanshan, Yang, Li, Bi, Chunmei, Shi, Yanbin, Liu, Yingqian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Danggui buxue decoction Diabetes Mellitus, Experimental Diabetes Mellitus, Type 2 - complications Diabetic Nephropathies - drug therapy Diabetic nephropathy Diet, High-Fat Drugs, Chinese Herbal - therapeutic use Gene Expression Regulation - drug effects Lipidomics Male Mice Mice, Inbred C57BL Network Pharmacology Phytotherapy RNA, Messenger - genetics RNA, Messenger - metabolism Specific Pathogen-Free Organisms Transcriptome Transcriptomics
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