PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation

Phospholipase D (PLD) generates the signaling lipid phosphatidic acid (PA) and has been known to mediate proliferation signal in vascular smooth muscle cells (VSMCs). However, it remains unclear how PLD contributes to vascular diseases. VSMC proliferation directly contributes to the development and...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular and cell biology of lipids 2022-01, Vol.1867 (1), p.159062-159062, Article 159062
Hauptverfasser:	Cai, Ming, Wang, Ziqing, Luu, Thi Thu Trang, Zhang, Dakai, Finke, Brian, He, Jingquan, Tay, Li Wei Rachel, Di Paolo, Gilbert, Du, Guangwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Carotid Arteries - metabolism Carotid Arteries - pathology Carotid Artery Injuries - genetics Carotid Artery Injuries - pathology Disease Models, Animal Humans Mice Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Neointima Neointima - genetics Neointima - metabolism Neointima - pathology Phospholipase D - genetics PLD1 Proliferation Reactive Oxygen Species - metabolism VSMC
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