Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs
Chronic kidney disease (CKD) and aging are known to possibly cause a progressive reduction in glomerular filtration rate, which may be associated with an increase in fractional excretion of electrolytes due to an adaptive response of the remaining functioning nephrons. However, the behavior of magne...
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| Veröffentlicht in: | Topics in companion animal medicine 2022-01, Vol.46, p.100588-100588, Article 100588 |
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| description | Chronic kidney disease (CKD) and aging are known to possibly cause a progressive reduction in glomerular filtration rate, which may be associated with an increase in fractional excretion of electrolytes due to an adaptive response of the remaining functioning nephrons. However, the behavior of magnesium excretion has not been studied in CKD and healthy elderly dogs. The objective was to evaluate the fractional excretion of magnesium (FEMg) in dogs with (CKD) compared to healthy elderly dogs. Sixteen healthy elderly dogs and 43 dogs with CKD were divided into 3 groups (CKD 2 [n = 14], CKD 3 [n = 17], CKD 4 [n = 12]), in accordance with the current International Renal Interest Society (IRIS) criteria that were used in this study. Blood samples were obtained by jugular venipuncture and urine samples were obtained by cystocentesis. The FEMg was evaluated at a single time point in both urine and blood samples. FEMg was significantly higher in dogs with CKD compared to healthy elderly dogs, especially in advanced stages. This preliminary study demonstrates that FEMg may be altered in dogs with CKD. Further research is warranted to elucidate magnesium's potential role in cardiovascular and arterial calcification in dogs with CKD as observed in humans with CKD. |
| doi_str_mv | 10.1016/j.tcam.2021.100588 |
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However, the behavior of magnesium excretion has not been studied in CKD and healthy elderly dogs. The objective was to evaluate the fractional excretion of magnesium (FEMg) in dogs with (CKD) compared to healthy elderly dogs. Sixteen healthy elderly dogs and 43 dogs with CKD were divided into 3 groups (CKD 2 [n = 14], CKD 3 [n = 17], CKD 4 [n = 12]), in accordance with the current International Renal Interest Society (IRIS) criteria that were used in this study. Blood samples were obtained by jugular venipuncture and urine samples were obtained by cystocentesis. The FEMg was evaluated at a single time point in both urine and blood samples. FEMg was significantly higher in dogs with CKD compared to healthy elderly dogs, especially in advanced stages. This preliminary study demonstrates that FEMg may be altered in dogs with CKD. Further research is warranted to elucidate magnesium's potential role in cardiovascular and arterial calcification in dogs with CKD as observed in humans with CKD.</description><identifier>ISSN: 1938-9736</identifier><identifier>EISSN: 1946-9837</identifier><identifier>EISSN: 1876-7613</identifier><identifier>DOI: 10.1016/j.tcam.2021.100588</identifier><identifier>PMID: 34610438</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging ; Animals ; Arteriosclerosis ; Atherosclerosis ; Automation ; Biochemistry ; Biomarkers ; Blood ; Blood pressure ; Calcification ; Calcification (ectopic) ; canine ; Creatinine ; Dog Diseases ; Dogs ; Electrolytes ; Excretion ; Geriatrics ; Glomerular filtration rate ; Glomerular Filtration Rate - veterinary ; Homeostasis ; kidney ; Kidney diseases ; Kidneys ; Magnesium ; Magnesium - metabolism ; magnesium homeostasis ; Males ; Medical prognosis ; Mortality ; nephrology ; Nephrons ; Normal distribution ; Older people ; Peritoneal dialysis ; Renal function ; Renal Insufficiency, Chronic - veterinary ; Ultrasonic imaging ; Urinalysis ; Veterinary medicine</subject><ispartof>Topics in companion animal medicine, 2022-01, Vol.46, p.100588-100588, Article 100588</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. 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Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c335t-9d68856e46e840101fa4a6e0e82e314b36605497b50b4bd56fba5cf97af624df3</cites><orcidid>0000-0003-4599-6641</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1938973621000817$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34610438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Lima, Charles Silva</creatorcontrib><creatorcontrib>Ferreira, Karina Rodrigues Gomes</creatorcontrib><creatorcontrib>Borin-Crivellenti, Sofia</creatorcontrib><creatorcontrib>Maia, Suellen Rodrigues</creatorcontrib><creatorcontrib>Santana, Aureo Evangelista</creatorcontrib><creatorcontrib>Crivellenti, Leandro Zuccolotto</creatorcontrib><title>Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs</title><title>Topics in companion animal medicine</title><addtitle>Top Companion Anim Med</addtitle><description>Chronic kidney disease (CKD) and aging are known to possibly cause a progressive reduction in glomerular filtration rate, which may be associated with an increase in fractional excretion of electrolytes due to an adaptive response of the remaining functioning nephrons. However, the behavior of magnesium excretion has not been studied in CKD and healthy elderly dogs. The objective was to evaluate the fractional excretion of magnesium (FEMg) in dogs with (CKD) compared to healthy elderly dogs. Sixteen healthy elderly dogs and 43 dogs with CKD were divided into 3 groups (CKD 2 [n = 14], CKD 3 [n = 17], CKD 4 [n = 12]), in accordance with the current International Renal Interest Society (IRIS) criteria that were used in this study. Blood samples were obtained by jugular venipuncture and urine samples were obtained by cystocentesis. The FEMg was evaluated at a single time point in both urine and blood samples. FEMg was significantly higher in dogs with CKD compared to healthy elderly dogs, especially in advanced stages. This preliminary study demonstrates that FEMg may be altered in dogs with CKD. Further research is warranted to elucidate magnesium's potential role in cardiovascular and arterial calcification in dogs with CKD as observed in humans with CKD.</description><subject>Aging</subject><subject>Animals</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Automation</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Blood pressure</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>canine</subject><subject>Creatinine</subject><subject>Dog Diseases</subject><subject>Dogs</subject><subject>Electrolytes</subject><subject>Excretion</subject><subject>Geriatrics</subject><subject>Glomerular filtration rate</subject><subject>Glomerular Filtration Rate - veterinary</subject><subject>Homeostasis</subject><subject>kidney</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Magnesium</subject><subject>Magnesium - metabolism</subject><subject>magnesium homeostasis</subject><subject>Males</subject><subject>Medical prognosis</subject><subject>Mortality</subject><subject>nephrology</subject><subject>Nephrons</subject><subject>Normal distribution</subject><subject>Older people</subject><subject>Peritoneal dialysis</subject><subject>Renal function</subject><subject>Renal Insufficiency, Chronic - veterinary</subject><subject>Ultrasonic imaging</subject><subject>Urinalysis</subject><subject>Veterinary medicine</subject><issn>1938-9736</issn><issn>1946-9837</issn><issn>1876-7613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9vEzEQxS0EoiXwBTggS1x62WCv_6wXcSlpIRVFSAjE0fLas4mjXTvYu0X59jikcODQ04xGv_ekeQ-hl5QsKaHyzW45WTMua1LTciBCqUfonLZcVq1izePjzlTVNkyeoWc57wiRpFXqKTpjXFLCmTpH268QzIA_m02A7OcRr01wgw-bt_gSr-K4N8nnGPB7mH4BBHwVNxn_8NMWr7YpBm_xJ-8CHPCVz2Ay4CLHazDDtD3g68FBGg5_RM_Rk94MGV7czwX6_uH622pd3X75eLO6vK0sY2KqWieVEhK4BMVJebM33EggoGpglHdMSiJ423SCdLxzQvadEbZvG9PLmrueLdDFyXef4s8Z8qRHny0MgwkQ56xr0bSylkI0BX39H7qLcypxFErWpBFUlZAWqD5RNsWcE_R6n_xo0kFToo896J0-9qCPPehTD0X06t567kZw_yR_gy_AuxMAJYs7D0ln6yFYcD6BnbSL_iH_3wI4l3Q</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>de Lima, Charles Silva</creator><creator>Ferreira, Karina Rodrigues Gomes</creator><creator>Borin-Crivellenti, Sofia</creator><creator>Maia, Suellen Rodrigues</creator><creator>Santana, Aureo Evangelista</creator><creator>Crivellenti, Leandro Zuccolotto</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4599-6641</orcidid></search><sort><creationdate>202201</creationdate><title>Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs</title><author>de Lima, Charles Silva ; 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| ispartof | Topics in companion animal medicine, 2022-01, Vol.46, p.100588-100588, Article 100588 |
| issn | 1938-9736 1946-9837 1876-7613 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aging Animals Arteriosclerosis Atherosclerosis Automation Biochemistry Biomarkers Blood Blood pressure Calcification Calcification (ectopic) canine Creatinine Dog Diseases Dogs Electrolytes Excretion Geriatrics Glomerular filtration rate Glomerular Filtration Rate - veterinary Homeostasis kidney Kidney diseases Kidneys Magnesium Magnesium - metabolism magnesium homeostasis Males Medical prognosis Mortality nephrology Nephrons Normal distribution Older people Peritoneal dialysis Renal function Renal Insufficiency, Chronic - veterinary Ultrasonic imaging Urinalysis Veterinary medicine |
| title | Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs |
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