Blastoid high-grade B-cell lymphoma initially presenting in bone marrow: a diagnostic challenge

The 2016 WHO classification introduced the category of high-grade B-cell lymphoma (HGBL), which includes one poorly understood subset, blastoid-HGBL. Establishing the diagnosis and distinguishing blastoid-HGBL from B-acute lymphoblastic leukemia (B-ALL) in bone marrow can be challenging. We assessed...

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Veröffentlicht in:	Modern pathology 2022-03, Vol.35 (3), p.419-426
Hauptverfasser:	Khanlari, Mahsa, Medeiros, L. Jeffrey, Lin, Pei, Xu, Jie, You, M. James, Tang, Guilin, Yin, C. Cameron, Wang, Wei, Qiu, Lianqun, Miranda, Roberto N., Bueso-Ramos, Carlos E., Li, Shaoying
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/51 14/32 692/308/575 692/699/1541/1990/291/1621/1915 Acute lymphoblastic leukemia B-cell lymphoma Bcl-6 protein Bone marrow Bone Marrow - pathology Bone tumors Burkitt Lymphoma - genetics CD20 antigen CD34 antigen CD38 antigen CD45 antigen Cytogenetics DNA nucleotidylexotransferase Fluorescence in situ hybridization Gene Rearrangement Humans In Situ Hybridization, Fluorescence Karyotypes Laboratory Medicine Lymphatic leukemia Lymphocytes B Lymphoma Lymphoma, B-Cell - diagnosis Lymphoma, B-Cell - genetics Lymphoma, B-Cell - pathology Lymphoma, Large B-Cell, Diffuse - pathology Medical diagnosis Medicine Medicine & Public Health Myc protein Next-generation sequencing p53 Protein Pathology Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-6 - genetics Proto-Oncogene Proteins c-myc - genetics Sequence analysis
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