Water-soluble trithiolato-bridged dinuclear ruthenium(II) and osmium(II) arene complexes with bisphosphonate functionalized ligands as anticancer organometallics

Trithiolato-bridged dinuclear ruthenium(II) complexes [Ru2(p-cym)2(SR)3]Cl (p-cym = p-cymene, R = benzyl derivatives) are regarded as the most cytotoxically potent metal(II) arene antineoplastics, but are oftentimes limited by their poor solubility in aqueous media. Thus, we designed bisphosphonate-...

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Veröffentlicht in:	Journal of inorganic biochemistry 2021-12, Vol.225, p.111618-111618, Article 111618
Hauptverfasser:	Riedl, Christoph A., Rosner, Alexander, Harringer, Sophia, Salomon, Philipp, Hejl, Michaela, Jakupec, Michael A., Kandioller, Wolfgang, Keppler, Bernhard K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Bisphosphonates Cell Line, Tumor Cell Proliferation - drug effects Coordination Complexes - chemical synthesis Coordination Complexes - pharmacology Diphosphonates - chemical synthesis Diphosphonates - pharmacology Drug Screening Assays, Antitumor Humans Hydroxy apatite binding Ligands Organometallics Osmium - chemistry Ruthenium Ruthenium - chemistry Solubility Targeting complexes Water - chemistry
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