Investigation of solvent microparticle formation in spray ionization–quadrupole ion trap–mass spectrometry
In the present study, a new method has been developed for the real‐time analysis of insource created solvent particles based on spray ionization–quadrupole ion trap–mass spectrometry (SI‐QIT‐MS). This is the first work in the literature reporting the formation of different solvent particles during s...
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Veröffentlicht in: | Journal of mass spectrometry. 2021-11, Vol.56 (11), p.e4785-n/a |
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description | In the present study, a new method has been developed for the real‐time analysis of insource created solvent particles based on spray ionization–quadrupole ion trap–mass spectrometry (SI‐QIT‐MS). This is the first work in the literature reporting the formation of different solvent particles during solvent spray in mass spectrometry. The solvent particles formed from the solvent droplets are detected by a charge detector. Our ion trap system allows the measurement of a wide range particle masses. Various solvents and solvent mixtures such as water, methanol, acetone, toluene, n‐butanol, water‐methanol, and water‐ethanol were sprayed through a cone system, and the mass of the particles was monitored by different trap frequencies and voltages. While polar molecules produce larger and more diverse particles due to their strong intermolecular forces, apolar solvents generally do not produce a significant number of particles. We obtained results using a homemade ion trap mass spectrometer capable of determining the mass of micro‐sized solvent and solvent mixture particles weighing up to 1015 (Da). The instrument uses a charge detector connected to the exit of the ion trap. Simultaneous acquisition of particle mass spectra and measurement of the amount of charge in each particle allow mass assignment of each particle. Sprayed solvent particles were examined at various trap frequencies and voltages to find the best instrumental parameters for the highest trapping efficiency. The custom SI‐QIT‐MS instrument allows the measurement of the mass distribution of charged particles from the solvent spray. |
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This is the first work in the literature reporting the formation of different solvent particles during solvent spray in mass spectrometry. The solvent particles formed from the solvent droplets are detected by a charge detector. Our ion trap system allows the measurement of a wide range particle masses. Various solvents and solvent mixtures such as water, methanol, acetone, toluene, n‐butanol, water‐methanol, and water‐ethanol were sprayed through a cone system, and the mass of the particles was monitored by different trap frequencies and voltages. While polar molecules produce larger and more diverse particles due to their strong intermolecular forces, apolar solvents generally do not produce a significant number of particles. We obtained results using a homemade ion trap mass spectrometer capable of determining the mass of micro‐sized solvent and solvent mixture particles weighing up to 1015 (Da). The instrument uses a charge detector connected to the exit of the ion trap. Simultaneous acquisition of particle mass spectra and measurement of the amount of charge in each particle allow mass assignment of each particle. Sprayed solvent particles were examined at various trap frequencies and voltages to find the best instrumental parameters for the highest trapping efficiency. The custom SI‐QIT‐MS instrument allows the measurement of the mass distribution of charged particles from the solvent spray.</description><identifier>ISSN: 1076-5174</identifier><identifier>EISSN: 1096-9888</identifier><identifier>DOI: 10.1002/jms.4785</identifier><language>eng</language><publisher>Bognor Regis: Wiley Subscription Services, Inc</publisher><subject>Acetone ; Butanol ; Charged particles ; Ethanol ; Intermolecular forces ; Ionization ; Ions ; Mass distribution ; Mass spectra ; Mass spectrometry ; Mass spectroscopy ; Measurement ; Methanol ; Microparticles ; Particle mass ; particle mass distribution ; Quadrupoles ; Scientific imaging ; SI‐QIT‐MS ; solvent microparticles ; Solvents ; Spectroscopy ; Toluene</subject><ispartof>Journal of mass spectrometry., 2021-11, Vol.56 (11), p.e4785-n/a</ispartof><rights>2021 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2875-2c2ae3a275ad7c1266a14aa9660e5422e091daec6ba676de44bcd091e37f497d3</cites><orcidid>0000-0003-3529-8751 ; 0000-0002-0900-0221 ; 0000-0002-2826-0002</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjms.4785$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjms.4785$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Özdemir, Abdil</creatorcontrib><creatorcontrib>Lin, Jung‐Lee</creatorcontrib><creatorcontrib>Gülfen, Mustafa</creatorcontrib><creatorcontrib>Chen, Chung‐Hsuan</creatorcontrib><title>Investigation of solvent microparticle formation in spray ionization–quadrupole ion trap–mass spectrometry</title><title>Journal of mass spectrometry.</title><description>In the present study, a new method has been developed for the real‐time analysis of insource created solvent particles based on spray ionization–quadrupole ion trap–mass spectrometry (SI‐QIT‐MS). This is the first work in the literature reporting the formation of different solvent particles during solvent spray in mass spectrometry. The solvent particles formed from the solvent droplets are detected by a charge detector. Our ion trap system allows the measurement of a wide range particle masses. Various solvents and solvent mixtures such as water, methanol, acetone, toluene, n‐butanol, water‐methanol, and water‐ethanol were sprayed through a cone system, and the mass of the particles was monitored by different trap frequencies and voltages. While polar molecules produce larger and more diverse particles due to their strong intermolecular forces, apolar solvents generally do not produce a significant number of particles. We obtained results using a homemade ion trap mass spectrometer capable of determining the mass of micro‐sized solvent and solvent mixture particles weighing up to 1015 (Da). The instrument uses a charge detector connected to the exit of the ion trap. Simultaneous acquisition of particle mass spectra and measurement of the amount of charge in each particle allow mass assignment of each particle. Sprayed solvent particles were examined at various trap frequencies and voltages to find the best instrumental parameters for the highest trapping efficiency. The custom SI‐QIT‐MS instrument allows the measurement of the mass distribution of charged particles from the solvent spray.</description><subject>Acetone</subject><subject>Butanol</subject><subject>Charged particles</subject><subject>Ethanol</subject><subject>Intermolecular forces</subject><subject>Ionization</subject><subject>Ions</subject><subject>Mass distribution</subject><subject>Mass spectra</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Measurement</subject><subject>Methanol</subject><subject>Microparticles</subject><subject>Particle mass</subject><subject>particle mass distribution</subject><subject>Quadrupoles</subject><subject>Scientific imaging</subject><subject>SI‐QIT‐MS</subject><subject>solvent microparticles</subject><subject>Solvents</subject><subject>Spectroscopy</subject><subject>Toluene</subject><issn>1076-5174</issn><issn>1096-9888</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10M1KxDAUBeAgCo6j4CMU3LjpmKRp0i5l8GdkxIW6DnfSVDK0TSdpR-rKd_ANfRJTRxAEV0kOH5fcg9ApwTOCMb1Y137GRJbuoQnBOY_zLMv2x7vgcUoEO0RH3q8xxnnO-AQ1i2arfWdeoDO2iWwZeVttddNFtVHOtuA6oyodldbVO2KayLcOhig8zNt39vn-semhcH1rAx1R56ANaQ3eB61V52ytOzcco4MSKq9Pfs4per6-eprfxsuHm8X8chkrmok0poqCToCKFAqhCOUcCAPIOcc6ZZRqnJMCtOIr4IIXmrGVKkKmE1GyXBTJFJ3v5rbObvqwoKyNV7qqoNG295KmIk8yTBMc6Nkfura9a8LvJOWYcpbiRPwODKV473QpW2dqcIMkWI7Fy1C8HIsPNN7RV1Pp4V8n7-4fv_0XVf-JJg</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Özdemir, Abdil</creator><creator>Lin, Jung‐Lee</creator><creator>Gülfen, Mustafa</creator><creator>Chen, Chung‐Hsuan</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7U5</scope><scope>7U7</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H97</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L.G</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3529-8751</orcidid><orcidid>https://orcid.org/0000-0002-0900-0221</orcidid><orcidid>https://orcid.org/0000-0002-2826-0002</orcidid></search><sort><creationdate>202111</creationdate><title>Investigation of solvent microparticle formation in spray ionization–quadrupole ion trap–mass spectrometry</title><author>Özdemir, Abdil ; Lin, Jung‐Lee ; Gülfen, Mustafa ; Chen, Chung‐Hsuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2875-2c2ae3a275ad7c1266a14aa9660e5422e091daec6ba676de44bcd091e37f497d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetone</topic><topic>Butanol</topic><topic>Charged particles</topic><topic>Ethanol</topic><topic>Intermolecular forces</topic><topic>Ionization</topic><topic>Ions</topic><topic>Mass distribution</topic><topic>Mass spectra</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Measurement</topic><topic>Methanol</topic><topic>Microparticles</topic><topic>Particle mass</topic><topic>particle mass distribution</topic><topic>Quadrupoles</topic><topic>Scientific imaging</topic><topic>SI‐QIT‐MS</topic><topic>solvent microparticles</topic><topic>Solvents</topic><topic>Spectroscopy</topic><topic>Toluene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Özdemir, Abdil</creatorcontrib><creatorcontrib>Lin, Jung‐Lee</creatorcontrib><creatorcontrib>Gülfen, Mustafa</creatorcontrib><creatorcontrib>Chen, Chung‐Hsuan</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of mass spectrometry.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özdemir, Abdil</au><au>Lin, Jung‐Lee</au><au>Gülfen, Mustafa</au><au>Chen, Chung‐Hsuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of solvent microparticle formation in spray ionization–quadrupole ion trap–mass spectrometry</atitle><jtitle>Journal of mass spectrometry.</jtitle><date>2021-11</date><risdate>2021</risdate><volume>56</volume><issue>11</issue><spage>e4785</spage><epage>n/a</epage><pages>e4785-n/a</pages><issn>1076-5174</issn><eissn>1096-9888</eissn><abstract>In the present study, a new method has been developed for the real‐time analysis of insource created solvent particles based on spray ionization–quadrupole ion trap–mass spectrometry (SI‐QIT‐MS). This is the first work in the literature reporting the formation of different solvent particles during solvent spray in mass spectrometry. The solvent particles formed from the solvent droplets are detected by a charge detector. Our ion trap system allows the measurement of a wide range particle masses. Various solvents and solvent mixtures such as water, methanol, acetone, toluene, n‐butanol, water‐methanol, and water‐ethanol were sprayed through a cone system, and the mass of the particles was monitored by different trap frequencies and voltages. While polar molecules produce larger and more diverse particles due to their strong intermolecular forces, apolar solvents generally do not produce a significant number of particles. We obtained results using a homemade ion trap mass spectrometer capable of determining the mass of micro‐sized solvent and solvent mixture particles weighing up to 1015 (Da). The instrument uses a charge detector connected to the exit of the ion trap. Simultaneous acquisition of particle mass spectra and measurement of the amount of charge in each particle allow mass assignment of each particle. Sprayed solvent particles were examined at various trap frequencies and voltages to find the best instrumental parameters for the highest trapping efficiency. The custom SI‐QIT‐MS instrument allows the measurement of the mass distribution of charged particles from the solvent spray.</abstract><cop>Bognor Regis</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/jms.4785</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3529-8751</orcidid><orcidid>https://orcid.org/0000-0002-0900-0221</orcidid><orcidid>https://orcid.org/0000-0002-2826-0002</orcidid></addata></record> |
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subjects | Acetone Butanol Charged particles Ethanol Intermolecular forces Ionization Ions Mass distribution Mass spectra Mass spectrometry Mass spectroscopy Measurement Methanol Microparticles Particle mass particle mass distribution Quadrupoles Scientific imaging SI‐QIT‐MS solvent microparticles Solvents Spectroscopy Toluene |
title | Investigation of solvent microparticle formation in spray ionization–quadrupole ion trap–mass spectrometry |
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