Sessile serrated lesions in patients with adenoma on index colonoscopy do not increase metachronous advanced adenoma risk
Objectives Post‐polypectomy surveillance intervals should be determined based on index colonoscopy findings. However, the risk of metachronous lesions, resulting from the coexistence of adenoma and sessile serrated lesions (SSLs), has rarely been addressed. We evaluated the impact of synchronous SSL...
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| Veröffentlicht in: | Digestive endoscopy 2022-05, Vol.34 (4), p.850-857 |
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| creator | Hong, Seung Wook Kim, Jeongseok Lee, Ji Young Lee, Jong‐Soo Chang, Hye‐Sook Park, Hye Won Kim, Gwang‐Un Yoon, Jiyoung Ye, Byong Duk Byeon, Jeong‐Sik Myung, Seung‐Jae Yang, Suk‐Kyun Choe, Jaewon Yang, Dong‐Hoon |
| description | Objectives
Post‐polypectomy surveillance intervals should be determined based on index colonoscopy findings. However, the risk of metachronous lesions, resulting from the coexistence of adenoma and sessile serrated lesions (SSLs), has rarely been addressed. We evaluated the impact of synchronous SSL on the risk of metachronous lesions within similar adenoma risk groups.
Methods
We retrieved individuals with one or more adenomas on index colonoscopy in a single‐center retrospective cohort and stratified them into four groups depending on the presence of SSL and low‐risk/high‐risk adenoma (LRA/HRA). Participants who underwent surveillance colonoscopies at least 12 months apart were included. We compared the risks of metachronous lesions including HRA, advanced adenoma (AA), or SSL within similar adenoma risk groups according to the presence of SSL.
Results
Overall 4493 individuals were included in the analysis. The risk of metachronous HRA/AA was not significantly higher in the adenoma with SSL group compared with the adenoma without SSL group, irrespective of LRA (HRA, 6/86 vs. 231/3297, P = 1.00; AA, 0/86 vs. 52/3297, P = 0.64) or HRA (HRA, 11/64 vs. 240/1046, P = 0.36; AA, 3/64 vs. 51/1046, P = 1.00). However, the risk of metachronous SSL in individuals with synchronous SSL was higher than that in those without SSL for both LRA (15/86 vs. 161/3297, P |
| doi_str_mv | 10.1111/den.14159 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2579379271</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2579379271</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3499-78e352dcd606e53a91ff652853e4e352b3fc3f3aca2d60bd5f0105e656c486c23</originalsourceid><addsrcrecordid>eNp1kD1PwzAQhi0EoqUw8AeQRxjS2vFHkxGV8iFVMABz5DoXNZDYxZdS-u9xKWXjFg_v4-dOLyHnnA15nFEJbsglV_kB6XMpRcK15oekz3KuEqWF6pETxDfGeJpLeUx6QmqW6Uz2yeYZEOsGKEIIpoOSNoC1d0hrR5emq8F1SNd1t6AmrvGtod7FrIQvan3jnUfrlxtaeup8FwMbwCDQFjpjFyHmK4w_P42z0b1XhBrfT8lRZRqEs993QF5vpy-T-2T2dPcwuZ4lVsg8T8YZCJWWttRMgxIm51WlVZopAXKbzEVlRSWMNWlE5qWqGGcKtNJWZtqmYkAud95l8B8rwK5oa7TQNMZBPK5I1TgX4zwd84he7VAbPGKAqliGujVhU3BWbJsu4v3FT9ORvfjVruYtlH_kvtoIjHbAOta7-d9U3Ewfd8pv7zKJ_Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2579379271</pqid></control><display><type>article</type><title>Sessile serrated lesions in patients with adenoma on index colonoscopy do not increase metachronous advanced adenoma risk</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Hong, Seung Wook ; Kim, Jeongseok ; Lee, Ji Young ; Lee, Jong‐Soo ; Chang, Hye‐Sook ; Park, Hye Won ; Kim, Gwang‐Un ; Yoon, Jiyoung ; Ye, Byong Duk ; Byeon, Jeong‐Sik ; Myung, Seung‐Jae ; Yang, Suk‐Kyun ; Choe, Jaewon ; Yang, Dong‐Hoon</creator><creatorcontrib>Hong, Seung Wook ; Kim, Jeongseok ; Lee, Ji Young ; Lee, Jong‐Soo ; Chang, Hye‐Sook ; Park, Hye Won ; Kim, Gwang‐Un ; Yoon, Jiyoung ; Ye, Byong Duk ; Byeon, Jeong‐Sik ; Myung, Seung‐Jae ; Yang, Suk‐Kyun ; Choe, Jaewon ; Yang, Dong‐Hoon</creatorcontrib><description>Objectives
Post‐polypectomy surveillance intervals should be determined based on index colonoscopy findings. However, the risk of metachronous lesions, resulting from the coexistence of adenoma and sessile serrated lesions (SSLs), has rarely been addressed. We evaluated the impact of synchronous SSL on the risk of metachronous lesions within similar adenoma risk groups.
Methods
We retrieved individuals with one or more adenomas on index colonoscopy in a single‐center retrospective cohort and stratified them into four groups depending on the presence of SSL and low‐risk/high‐risk adenoma (LRA/HRA). Participants who underwent surveillance colonoscopies at least 12 months apart were included. We compared the risks of metachronous lesions including HRA, advanced adenoma (AA), or SSL within similar adenoma risk groups according to the presence of SSL.
Results
Overall 4493 individuals were included in the analysis. The risk of metachronous HRA/AA was not significantly higher in the adenoma with SSL group compared with the adenoma without SSL group, irrespective of LRA (HRA, 6/86 vs. 231/3297, P = 1.00; AA, 0/86 vs. 52/3297, P = 0.64) or HRA (HRA, 11/64 vs. 240/1046, P = 0.36; AA, 3/64 vs. 51/1046, P = 1.00). However, the risk of metachronous SSL in individuals with synchronous SSL was higher than that in those without SSL for both LRA (15/86 vs. 161/3297, P < 0.001) and HRA groups (11/64 vs. 61/1046, P = 0.002).
Conclusion
The presence of synchronous SSL did not increase the risk of metachronous HRA/AA, compared with isolated adenoma, but increased the risk of metachronous SSL.</description><identifier>ISSN: 0915-5635</identifier><identifier>EISSN: 1443-1661</identifier><identifier>DOI: 10.1111/den.14159</identifier><identifier>PMID: 34608684</identifier><language>eng</language><publisher>Australia</publisher><subject>adenoma ; Adenoma - pathology ; cohort study ; colonic polyp ; Colonic Polyps - pathology ; Colonoscopy ; Colorectal Neoplasms - pathology ; Humans ; Neoplasms, Second Primary - diagnosis ; Neoplasms, Second Primary - epidemiology ; Retrospective Studies ; risk assessment</subject><ispartof>Digestive endoscopy, 2022-05, Vol.34 (4), p.850-857</ispartof><rights>2021 Japan Gastroenterological Endoscopy Society</rights><rights>2021 Japan Gastroenterological Endoscopy Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3499-78e352dcd606e53a91ff652853e4e352b3fc3f3aca2d60bd5f0105e656c486c23</citedby><cites>FETCH-LOGICAL-c3499-78e352dcd606e53a91ff652853e4e352b3fc3f3aca2d60bd5f0105e656c486c23</cites><orcidid>0000-0001-7756-2704</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fden.14159$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fden.14159$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34608684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, Seung Wook</creatorcontrib><creatorcontrib>Kim, Jeongseok</creatorcontrib><creatorcontrib>Lee, Ji Young</creatorcontrib><creatorcontrib>Lee, Jong‐Soo</creatorcontrib><creatorcontrib>Chang, Hye‐Sook</creatorcontrib><creatorcontrib>Park, Hye Won</creatorcontrib><creatorcontrib>Kim, Gwang‐Un</creatorcontrib><creatorcontrib>Yoon, Jiyoung</creatorcontrib><creatorcontrib>Ye, Byong Duk</creatorcontrib><creatorcontrib>Byeon, Jeong‐Sik</creatorcontrib><creatorcontrib>Myung, Seung‐Jae</creatorcontrib><creatorcontrib>Yang, Suk‐Kyun</creatorcontrib><creatorcontrib>Choe, Jaewon</creatorcontrib><creatorcontrib>Yang, Dong‐Hoon</creatorcontrib><title>Sessile serrated lesions in patients with adenoma on index colonoscopy do not increase metachronous advanced adenoma risk</title><title>Digestive endoscopy</title><addtitle>Dig Endosc</addtitle><description>Objectives
Post‐polypectomy surveillance intervals should be determined based on index colonoscopy findings. However, the risk of metachronous lesions, resulting from the coexistence of adenoma and sessile serrated lesions (SSLs), has rarely been addressed. We evaluated the impact of synchronous SSL on the risk of metachronous lesions within similar adenoma risk groups.
Methods
We retrieved individuals with one or more adenomas on index colonoscopy in a single‐center retrospective cohort and stratified them into four groups depending on the presence of SSL and low‐risk/high‐risk adenoma (LRA/HRA). Participants who underwent surveillance colonoscopies at least 12 months apart were included. We compared the risks of metachronous lesions including HRA, advanced adenoma (AA), or SSL within similar adenoma risk groups according to the presence of SSL.
Results
Overall 4493 individuals were included in the analysis. The risk of metachronous HRA/AA was not significantly higher in the adenoma with SSL group compared with the adenoma without SSL group, irrespective of LRA (HRA, 6/86 vs. 231/3297, P = 1.00; AA, 0/86 vs. 52/3297, P = 0.64) or HRA (HRA, 11/64 vs. 240/1046, P = 0.36; AA, 3/64 vs. 51/1046, P = 1.00). However, the risk of metachronous SSL in individuals with synchronous SSL was higher than that in those without SSL for both LRA (15/86 vs. 161/3297, P < 0.001) and HRA groups (11/64 vs. 61/1046, P = 0.002).
Conclusion
The presence of synchronous SSL did not increase the risk of metachronous HRA/AA, compared with isolated adenoma, but increased the risk of metachronous SSL.</description><subject>adenoma</subject><subject>Adenoma - pathology</subject><subject>cohort study</subject><subject>colonic polyp</subject><subject>Colonic Polyps - pathology</subject><subject>Colonoscopy</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Humans</subject><subject>Neoplasms, Second Primary - diagnosis</subject><subject>Neoplasms, Second Primary - epidemiology</subject><subject>Retrospective Studies</subject><subject>risk assessment</subject><issn>0915-5635</issn><issn>1443-1661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EoqUw8AeQRxjS2vFHkxGV8iFVMABz5DoXNZDYxZdS-u9xKWXjFg_v4-dOLyHnnA15nFEJbsglV_kB6XMpRcK15oekz3KuEqWF6pETxDfGeJpLeUx6QmqW6Uz2yeYZEOsGKEIIpoOSNoC1d0hrR5emq8F1SNd1t6AmrvGtod7FrIQvan3jnUfrlxtaeup8FwMbwCDQFjpjFyHmK4w_P42z0b1XhBrfT8lRZRqEs993QF5vpy-T-2T2dPcwuZ4lVsg8T8YZCJWWttRMgxIm51WlVZopAXKbzEVlRSWMNWlE5qWqGGcKtNJWZtqmYkAud95l8B8rwK5oa7TQNMZBPK5I1TgX4zwd84he7VAbPGKAqliGujVhU3BWbJsu4v3FT9ORvfjVruYtlH_kvtoIjHbAOta7-d9U3Ewfd8pv7zKJ_Q</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Hong, Seung Wook</creator><creator>Kim, Jeongseok</creator><creator>Lee, Ji Young</creator><creator>Lee, Jong‐Soo</creator><creator>Chang, Hye‐Sook</creator><creator>Park, Hye Won</creator><creator>Kim, Gwang‐Un</creator><creator>Yoon, Jiyoung</creator><creator>Ye, Byong Duk</creator><creator>Byeon, Jeong‐Sik</creator><creator>Myung, Seung‐Jae</creator><creator>Yang, Suk‐Kyun</creator><creator>Choe, Jaewon</creator><creator>Yang, Dong‐Hoon</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7756-2704</orcidid></search><sort><creationdate>202205</creationdate><title>Sessile serrated lesions in patients with adenoma on index colonoscopy do not increase metachronous advanced adenoma risk</title><author>Hong, Seung Wook ; Kim, Jeongseok ; Lee, Ji Young ; Lee, Jong‐Soo ; Chang, Hye‐Sook ; Park, Hye Won ; Kim, Gwang‐Un ; Yoon, Jiyoung ; Ye, Byong Duk ; Byeon, Jeong‐Sik ; Myung, Seung‐Jae ; Yang, Suk‐Kyun ; Choe, Jaewon ; Yang, Dong‐Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3499-78e352dcd606e53a91ff652853e4e352b3fc3f3aca2d60bd5f0105e656c486c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>adenoma</topic><topic>Adenoma - pathology</topic><topic>cohort study</topic><topic>colonic polyp</topic><topic>Colonic Polyps - pathology</topic><topic>Colonoscopy</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Humans</topic><topic>Neoplasms, Second Primary - diagnosis</topic><topic>Neoplasms, Second Primary - epidemiology</topic><topic>Retrospective Studies</topic><topic>risk assessment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Seung Wook</creatorcontrib><creatorcontrib>Kim, Jeongseok</creatorcontrib><creatorcontrib>Lee, Ji Young</creatorcontrib><creatorcontrib>Lee, Jong‐Soo</creatorcontrib><creatorcontrib>Chang, Hye‐Sook</creatorcontrib><creatorcontrib>Park, Hye Won</creatorcontrib><creatorcontrib>Kim, Gwang‐Un</creatorcontrib><creatorcontrib>Yoon, Jiyoung</creatorcontrib><creatorcontrib>Ye, Byong Duk</creatorcontrib><creatorcontrib>Byeon, Jeong‐Sik</creatorcontrib><creatorcontrib>Myung, Seung‐Jae</creatorcontrib><creatorcontrib>Yang, Suk‐Kyun</creatorcontrib><creatorcontrib>Choe, Jaewon</creatorcontrib><creatorcontrib>Yang, Dong‐Hoon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Seung Wook</au><au>Kim, Jeongseok</au><au>Lee, Ji Young</au><au>Lee, Jong‐Soo</au><au>Chang, Hye‐Sook</au><au>Park, Hye Won</au><au>Kim, Gwang‐Un</au><au>Yoon, Jiyoung</au><au>Ye, Byong Duk</au><au>Byeon, Jeong‐Sik</au><au>Myung, Seung‐Jae</au><au>Yang, Suk‐Kyun</au><au>Choe, Jaewon</au><au>Yang, Dong‐Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sessile serrated lesions in patients with adenoma on index colonoscopy do not increase metachronous advanced adenoma risk</atitle><jtitle>Digestive endoscopy</jtitle><addtitle>Dig Endosc</addtitle><date>2022-05</date><risdate>2022</risdate><volume>34</volume><issue>4</issue><spage>850</spage><epage>857</epage><pages>850-857</pages><issn>0915-5635</issn><eissn>1443-1661</eissn><abstract>Objectives
Post‐polypectomy surveillance intervals should be determined based on index colonoscopy findings. However, the risk of metachronous lesions, resulting from the coexistence of adenoma and sessile serrated lesions (SSLs), has rarely been addressed. We evaluated the impact of synchronous SSL on the risk of metachronous lesions within similar adenoma risk groups.
Methods
We retrieved individuals with one or more adenomas on index colonoscopy in a single‐center retrospective cohort and stratified them into four groups depending on the presence of SSL and low‐risk/high‐risk adenoma (LRA/HRA). Participants who underwent surveillance colonoscopies at least 12 months apart were included. We compared the risks of metachronous lesions including HRA, advanced adenoma (AA), or SSL within similar adenoma risk groups according to the presence of SSL.
Results
Overall 4493 individuals were included in the analysis. The risk of metachronous HRA/AA was not significantly higher in the adenoma with SSL group compared with the adenoma without SSL group, irrespective of LRA (HRA, 6/86 vs. 231/3297, P = 1.00; AA, 0/86 vs. 52/3297, P = 0.64) or HRA (HRA, 11/64 vs. 240/1046, P = 0.36; AA, 3/64 vs. 51/1046, P = 1.00). However, the risk of metachronous SSL in individuals with synchronous SSL was higher than that in those without SSL for both LRA (15/86 vs. 161/3297, P < 0.001) and HRA groups (11/64 vs. 61/1046, P = 0.002).
Conclusion
The presence of synchronous SSL did not increase the risk of metachronous HRA/AA, compared with isolated adenoma, but increased the risk of metachronous SSL.</abstract><cop>Australia</cop><pmid>34608684</pmid><doi>10.1111/den.14159</doi><tpages>857</tpages><orcidid>https://orcid.org/0000-0001-7756-2704</orcidid></addata></record> |
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| ispartof | Digestive endoscopy, 2022-05, Vol.34 (4), p.850-857 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | adenoma Adenoma - pathology cohort study colonic polyp Colonic Polyps - pathology Colonoscopy Colorectal Neoplasms - pathology Humans Neoplasms, Second Primary - diagnosis Neoplasms, Second Primary - epidemiology Retrospective Studies risk assessment |
| title | Sessile serrated lesions in patients with adenoma on index colonoscopy do not increase metachronous advanced adenoma risk |
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