CEMIP, a novel adaptor protein of OGT, promotes colorectal cancer metastasis through glutamine metabolic reprogramming via reciprocal regulation of β-catenin

Metastasis is the leading cause of colorectal cancer (CRC)-induced death. However, the underlying molecular mechanisms of CRC metastasis are poorly understood. Metabolic reprogramming is an intrinsic feature of cancer, which have complicated effects on cancer metastasis. Here, we find that a novel m...

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Veröffentlicht in:	Oncogene 2021-11, Vol.40 (46), p.6443-6455
Hauptverfasser:	Hua, Qingling, Zhang, Biying, Xu, Guojie, Wang, Lanqing, Wang, Haihong, Lin, Zhenyu, Yu, Dandan, Ren, Jinghua, Zhang, Dejun, Zhao, Lei, Zhang, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 13/51 13/89 14/19 38/77 631/67/322 631/80/86 64/60 82/29 82/51 82/83 Amino Acid Transport System A - metabolism Amino Acid Transport System ASC - metabolism Animals Apoptosis beta Catenin - metabolism Cancer Cell Biology Cell Line, Tumor Cell migration Cell Nucleus - metabolism Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Female Gene Expression Regulation, Neoplastic Glutaminase Glutamine Glutamine - metabolism HCT116 Cells Human Genetics Humans Hyaluronic acid Hyaluronoglucosaminidase - genetics Hyaluronoglucosaminidase - metabolism Internal Medicine Medicine Medicine & Public Health Metabolism Metastases Metastasis Mice Minor Histocompatibility Antigens - metabolism Molecular modelling N-Acetylglucosaminyltransferases - metabolism Neoplasm Metastasis Neoplasm Transplantation Nuclear transport O-GlcNAcylation Oncology Overexpression Proteins Transcription Transcription, Genetic β-Catenin
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