Alleviation of cognitive impairment by gut microbiota lipopolysaccharide production-suppressing Lactobacillus plantarum and Bifidobacterium longum in mice

Bacterial lipopolysaccharide (LPS) is a risk factor for the outbreak of Alzheimer's disease. Therefore, we isolated NK151 and NK173 from a human fecal bacteria collection, which inhibited LPS production, and examined their effects on the K1- or LPS-induced cognitive impairment in mice. Oral gav...

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Veröffentlicht in:	Food & function 2021-11, Vol.12 (21), p.10750-10763
Hauptverfasser:	Lee, Dong-Yun, Shin, Yoon-Jung, Kim, Jeon-Kyung, Jang, Hyo-Min, Joo, Min-Kyung, Kim, Dong-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Apolipoprotein E Bifidobacterium longum Blood Brain-derived neurotrophic factor Cognition Cognitive ability Cognitive Dysfunction - chemically induced Cognitive Dysfunction - prevention & control Coliforms Colitis Colon E coli Escherichia coli Feces Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - physiology Genome, Bacterial Hippocampus IL-1β Impairment Inflammation Interleukin 6 Intestinal microflora Lactobacilli Lactobacillus plantarum Lipopolysaccharides Lipopolysaccharides - metabolism Male Markers Mice Microbiota Neurodegenerative diseases NF-κB protein Object recognition Pattern recognition Populations Probiotics - pharmacology Risk analysis Risk factors RNA, Bacterial - genetics RNA, Ribosomal, 16S - genetics Specific Pathogen-Free Organisms Tumor necrosis factor-α Whole Genome Sequencing
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