Alleviation of cognitive impairment by gut microbiota lipopolysaccharide production-suppressing Lactobacillus plantarum and Bifidobacterium longum in mice
Bacterial lipopolysaccharide (LPS) is a risk factor for the outbreak of Alzheimer's disease. Therefore, we isolated NK151 and NK173 from a human fecal bacteria collection, which inhibited LPS production, and examined their effects on the K1- or LPS-induced cognitive impairment in mice. Oral gav...
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description | Bacterial lipopolysaccharide (LPS) is a risk factor for the outbreak of Alzheimer's disease. Therefore, we isolated
NK151 and
NK173 from a human fecal bacteria collection, which inhibited
LPS production, and examined their effects on the
K1- or LPS-induced cognitive impairment in mice. Oral gavage of NK151, NK173, or their (4 : 1) mixture (NKm) significantly alleviated
K1-induced cognitive impairment-like behaviors in the Y-maze and novel object recognition tasks. Their treatments decreased IL-1β, IL-6, and TNF-α expression and NF-κB
/Iba1
and LPS
/Iba1
cell populations in the hippocampus, while the brain-derived neurotrophic factor (BDNF)
/neuronal nuclei (NeuN)
cell population and BDNF to proBNDF expression increased. They suppressed LPS-induced cognition impairment-like behaviors and neuroinflammation marker levels in the hippocampus. Treatment with them reduced
K1- or LPS-induced LPS and apolipoprotein E levels in the blood and inflammatory marker levels in the colon. Furthermore, treatment with them modulated fecal Proteobacteria, Bacteroidetes, and Verrucomicrobia populations. Of these gut bacteria, Bacteroidaceae, Odoribacteraceae, Lactobacillaceae, Bifidobacteriaceae, Rikenellaceae, Helicobacteraceae, and Deferribacteraceae are correlated with cognitive function and blood and fecal LPS levels. These findings suggest that NK151 and NK173 may alleviate cognitive impairment with colitis by upregulating NF-κB-mediated BDNF expression through the suppression of fecal and blood bacterial LPS levels. |
doi_str_mv | 10.1039/d1fo02167b |
format | Article |
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NK151 and
NK173 from a human fecal bacteria collection, which inhibited
LPS production, and examined their effects on the
K1- or LPS-induced cognitive impairment in mice. Oral gavage of NK151, NK173, or their (4 : 1) mixture (NKm) significantly alleviated
K1-induced cognitive impairment-like behaviors in the Y-maze and novel object recognition tasks. Their treatments decreased IL-1β, IL-6, and TNF-α expression and NF-κB
/Iba1
and LPS
/Iba1
cell populations in the hippocampus, while the brain-derived neurotrophic factor (BDNF)
/neuronal nuclei (NeuN)
cell population and BDNF to proBNDF expression increased. They suppressed LPS-induced cognition impairment-like behaviors and neuroinflammation marker levels in the hippocampus. Treatment with them reduced
K1- or LPS-induced LPS and apolipoprotein E levels in the blood and inflammatory marker levels in the colon. Furthermore, treatment with them modulated fecal Proteobacteria, Bacteroidetes, and Verrucomicrobia populations. Of these gut bacteria, Bacteroidaceae, Odoribacteraceae, Lactobacillaceae, Bifidobacteriaceae, Rikenellaceae, Helicobacteraceae, and Deferribacteraceae are correlated with cognitive function and blood and fecal LPS levels. These findings suggest that NK151 and NK173 may alleviate cognitive impairment with colitis by upregulating NF-κB-mediated BDNF expression through the suppression of fecal and blood bacterial LPS levels.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d1fo02167b</identifier><identifier>PMID: 34608923</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Alzheimer's disease ; Animals ; Apolipoprotein E ; Bifidobacterium longum ; Blood ; Brain-derived neurotrophic factor ; Cognition ; Cognitive ability ; Cognitive Dysfunction - chemically induced ; Cognitive Dysfunction - prevention & control ; Coliforms ; Colitis ; Colon ; E coli ; Escherichia coli ; Feces ; Gastrointestinal Microbiome - drug effects ; Gastrointestinal Microbiome - physiology ; Genome, Bacterial ; Hippocampus ; IL-1β ; Impairment ; Inflammation ; Interleukin 6 ; Intestinal microflora ; Lactobacilli ; Lactobacillus plantarum ; Lipopolysaccharides ; Lipopolysaccharides - metabolism ; Male ; Markers ; Mice ; Microbiota ; Neurodegenerative diseases ; NF-κB protein ; Object recognition ; Pattern recognition ; Populations ; Probiotics - pharmacology ; Risk analysis ; Risk factors ; RNA, Bacterial - genetics ; RNA, Ribosomal, 16S - genetics ; Specific Pathogen-Free Organisms ; Tumor necrosis factor-α ; Whole Genome Sequencing</subject><ispartof>Food & function, 2021-11, Vol.12 (21), p.10750-10763</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-a02f90efca1f435b52405d67d565ede6455b2b4483f21d159728f3886653fa8e3</citedby><cites>FETCH-LOGICAL-c392t-a02f90efca1f435b52405d67d565ede6455b2b4483f21d159728f3886653fa8e3</cites><orcidid>0000-0003-4783-7900 ; 0000-0001-6746-6364</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34608923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Dong-Yun</creatorcontrib><creatorcontrib>Shin, Yoon-Jung</creatorcontrib><creatorcontrib>Kim, Jeon-Kyung</creatorcontrib><creatorcontrib>Jang, Hyo-Min</creatorcontrib><creatorcontrib>Joo, Min-Kyung</creatorcontrib><creatorcontrib>Kim, Dong-Hyun</creatorcontrib><title>Alleviation of cognitive impairment by gut microbiota lipopolysaccharide production-suppressing Lactobacillus plantarum and Bifidobacterium longum in mice</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Bacterial lipopolysaccharide (LPS) is a risk factor for the outbreak of Alzheimer's disease. Therefore, we isolated
NK151 and
NK173 from a human fecal bacteria collection, which inhibited
LPS production, and examined their effects on the
K1- or LPS-induced cognitive impairment in mice. Oral gavage of NK151, NK173, or their (4 : 1) mixture (NKm) significantly alleviated
K1-induced cognitive impairment-like behaviors in the Y-maze and novel object recognition tasks. Their treatments decreased IL-1β, IL-6, and TNF-α expression and NF-κB
/Iba1
and LPS
/Iba1
cell populations in the hippocampus, while the brain-derived neurotrophic factor (BDNF)
/neuronal nuclei (NeuN)
cell population and BDNF to proBNDF expression increased. They suppressed LPS-induced cognition impairment-like behaviors and neuroinflammation marker levels in the hippocampus. Treatment with them reduced
K1- or LPS-induced LPS and apolipoprotein E levels in the blood and inflammatory marker levels in the colon. Furthermore, treatment with them modulated fecal Proteobacteria, Bacteroidetes, and Verrucomicrobia populations. Of these gut bacteria, Bacteroidaceae, Odoribacteraceae, Lactobacillaceae, Bifidobacteriaceae, Rikenellaceae, Helicobacteraceae, and Deferribacteraceae are correlated with cognitive function and blood and fecal LPS levels. These findings suggest that NK151 and NK173 may alleviate cognitive impairment with colitis by upregulating NF-κB-mediated BDNF expression through the suppression of fecal and blood bacterial LPS levels.</description><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Apolipoprotein E</subject><subject>Bifidobacterium longum</subject><subject>Blood</subject><subject>Brain-derived neurotrophic factor</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - chemically induced</subject><subject>Cognitive Dysfunction - prevention & control</subject><subject>Coliforms</subject><subject>Colitis</subject><subject>Colon</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Feces</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Genome, Bacterial</subject><subject>Hippocampus</subject><subject>IL-1β</subject><subject>Impairment</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Intestinal microflora</subject><subject>Lactobacilli</subject><subject>Lactobacillus plantarum</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - metabolism</subject><subject>Male</subject><subject>Markers</subject><subject>Mice</subject><subject>Microbiota</subject><subject>Neurodegenerative diseases</subject><subject>NF-κB protein</subject><subject>Object recognition</subject><subject>Pattern recognition</subject><subject>Populations</subject><subject>Probiotics - pharmacology</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>RNA, Bacterial - genetics</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Tumor necrosis factor-α</subject><subject>Whole Genome Sequencing</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctqVTEUhoMottROfAAJOBFhay472cmwF6vCgU4UnG2yczmmZCfbXArnVXxac2zrwExWyPr415_1A_Aaow8YUfnRYJcQwXxanoFTgkYycIZ-PH-6j5KfgPNS7lA_VEohxUtwQkeOhCT0FPy-CMHee1V9ijA5qNM--urvLfTrpnxebaxwOcB9q3D1OqfFp6pg8FvaUjgUpfVPlb2xcMvJNH3UGUrbtmxL8XEPd0rXtCjtQ2gFbkHFqnJboYoGXnrnzbFZbfb9LaS478XH4yj7CrxwKhR7_ljPwPebT9-uvgy7289fry52g6aS1EEh4iSyTivsRsoWRkbEDJ8M48way0fGFrKMo6COYIOZnIhwVAjOGXVKWHoG3j3o9h_8arbUefVF29Ct2tTKTNgk6SQI4x19-x96l1qO3V2nJCZSSiw69f6B6usqJVs3b9mvKh9mjOZjaPM1vrn9G9plh988SrZlteYf-hQR_QMgIJV6</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Lee, Dong-Yun</creator><creator>Shin, Yoon-Jung</creator><creator>Kim, Jeon-Kyung</creator><creator>Jang, Hyo-Min</creator><creator>Joo, Min-Kyung</creator><creator>Kim, Dong-Hyun</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4783-7900</orcidid><orcidid>https://orcid.org/0000-0001-6746-6364</orcidid></search><sort><creationdate>20211101</creationdate><title>Alleviation of cognitive impairment by gut microbiota lipopolysaccharide production-suppressing Lactobacillus plantarum and Bifidobacterium longum in mice</title><author>Lee, Dong-Yun ; Shin, Yoon-Jung ; Kim, Jeon-Kyung ; Jang, Hyo-Min ; Joo, Min-Kyung ; Kim, Dong-Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-a02f90efca1f435b52405d67d565ede6455b2b4483f21d159728f3886653fa8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Apolipoprotein E</topic><topic>Bifidobacterium longum</topic><topic>Blood</topic><topic>Brain-derived neurotrophic factor</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - chemically induced</topic><topic>Cognitive Dysfunction - prevention & control</topic><topic>Coliforms</topic><topic>Colitis</topic><topic>Colon</topic><topic>E coli</topic><topic>Escherichia coli</topic><topic>Feces</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Gastrointestinal Microbiome - physiology</topic><topic>Genome, Bacterial</topic><topic>Hippocampus</topic><topic>IL-1β</topic><topic>Impairment</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Intestinal microflora</topic><topic>Lactobacilli</topic><topic>Lactobacillus plantarum</topic><topic>Lipopolysaccharides</topic><topic>Lipopolysaccharides - metabolism</topic><topic>Male</topic><topic>Markers</topic><topic>Mice</topic><topic>Microbiota</topic><topic>Neurodegenerative diseases</topic><topic>NF-κB protein</topic><topic>Object recognition</topic><topic>Pattern recognition</topic><topic>Populations</topic><topic>Probiotics - pharmacology</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>RNA, Bacterial - genetics</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Tumor necrosis factor-α</topic><topic>Whole Genome Sequencing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Dong-Yun</creatorcontrib><creatorcontrib>Shin, Yoon-Jung</creatorcontrib><creatorcontrib>Kim, Jeon-Kyung</creatorcontrib><creatorcontrib>Jang, Hyo-Min</creatorcontrib><creatorcontrib>Joo, Min-Kyung</creatorcontrib><creatorcontrib>Kim, Dong-Hyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Dong-Yun</au><au>Shin, Yoon-Jung</au><au>Kim, Jeon-Kyung</au><au>Jang, Hyo-Min</au><au>Joo, Min-Kyung</au><au>Kim, Dong-Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alleviation of cognitive impairment by gut microbiota lipopolysaccharide production-suppressing Lactobacillus plantarum and Bifidobacterium longum in mice</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>12</volume><issue>21</issue><spage>10750</spage><epage>10763</epage><pages>10750-10763</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Bacterial lipopolysaccharide (LPS) is a risk factor for the outbreak of Alzheimer's disease. Therefore, we isolated
NK151 and
NK173 from a human fecal bacteria collection, which inhibited
LPS production, and examined their effects on the
K1- or LPS-induced cognitive impairment in mice. Oral gavage of NK151, NK173, or their (4 : 1) mixture (NKm) significantly alleviated
K1-induced cognitive impairment-like behaviors in the Y-maze and novel object recognition tasks. Their treatments decreased IL-1β, IL-6, and TNF-α expression and NF-κB
/Iba1
and LPS
/Iba1
cell populations in the hippocampus, while the brain-derived neurotrophic factor (BDNF)
/neuronal nuclei (NeuN)
cell population and BDNF to proBNDF expression increased. They suppressed LPS-induced cognition impairment-like behaviors and neuroinflammation marker levels in the hippocampus. Treatment with them reduced
K1- or LPS-induced LPS and apolipoprotein E levels in the blood and inflammatory marker levels in the colon. Furthermore, treatment with them modulated fecal Proteobacteria, Bacteroidetes, and Verrucomicrobia populations. Of these gut bacteria, Bacteroidaceae, Odoribacteraceae, Lactobacillaceae, Bifidobacteriaceae, Rikenellaceae, Helicobacteraceae, and Deferribacteraceae are correlated with cognitive function and blood and fecal LPS levels. These findings suggest that NK151 and NK173 may alleviate cognitive impairment with colitis by upregulating NF-κB-mediated BDNF expression through the suppression of fecal and blood bacterial LPS levels.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>34608923</pmid><doi>10.1039/d1fo02167b</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-4783-7900</orcidid><orcidid>https://orcid.org/0000-0001-6746-6364</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Alzheimer's disease Animals Apolipoprotein E Bifidobacterium longum Blood Brain-derived neurotrophic factor Cognition Cognitive ability Cognitive Dysfunction - chemically induced Cognitive Dysfunction - prevention & control Coliforms Colitis Colon E coli Escherichia coli Feces Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - physiology Genome, Bacterial Hippocampus IL-1β Impairment Inflammation Interleukin 6 Intestinal microflora Lactobacilli Lactobacillus plantarum Lipopolysaccharides Lipopolysaccharides - metabolism Male Markers Mice Microbiota Neurodegenerative diseases NF-κB protein Object recognition Pattern recognition Populations Probiotics - pharmacology Risk analysis Risk factors RNA, Bacterial - genetics RNA, Ribosomal, 16S - genetics Specific Pathogen-Free Organisms Tumor necrosis factor-α Whole Genome Sequencing |
title | Alleviation of cognitive impairment by gut microbiota lipopolysaccharide production-suppressing Lactobacillus plantarum and Bifidobacterium longum in mice |
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