Somatosensory behavioral alterations in a NGF-induced persistent low back pain model

Low back pain (LBP) is a major global burden in part due to the underlying pathophysiological mechanisms being poorly understood. A LBP rat model involving two injections of nerve growth factor (NGF, an endogenous pain-related neurotrophin) into trunk musculature was recently developed. Additional b...

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Veröffentlicht in:	Behavioural brain research 2022-02, Vol.418, p.113617-113617, Article 113617
Hauptverfasser:	Reed, Nicholas R., Reed, William R., Syrett, Michael, Richey, Madison L., Frolov, Andrey, Little, Joshua W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - physiology Disease Models, Animal Female Hyperalgesia - physiopathology Low back pain Low Back Pain - chemically induced Low Back Pain - physiopathology Male Mechanical hyperalgesia Mechanical hypersensitivity Nerve growth factor Nerve Growth Factor - administration & dosage Nerve Growth Factor - adverse effects Pain Rats Rats, Sprague-Dawley
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