Intracellular calcium and inflammatory markers, mediated by purinergic stimulation, are differentially regulated in monocytes of patients with major depressive disorder

[Display omitted] •P2X7R activation introduced [Ca2+]c imbalance in monocytes from Mayor Depression Disease patients.•[Ca2+]c imbalance induced TNF-α and caspase-1 activation in monocytes from MDD patients.•P2X7R blockade with JNJ-47965567, reduces the [Ca2+]c upon Bz-ATP exposure.•MDD patients have...

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Veröffentlicht in:	Neuroscience letters 2021-11, Vol.765, p.136275-136275, Article 136275
Hauptverfasser:	Garrosa-Jiménez, Javier, Sánchez Carro, Yolanda, Ovejero-Benito, María C., del Sastre, Eric, García, Antonio G., López, Manuela G., López-García, Pilar, Cano-Abad, María F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Calcium - metabolism Calcium homeostasis Cells, Cultured Depressive Disorder, Major - immunology Depressive Disorder, Major - metabolism Female Humans Inflammasomes - metabolism Inflammation Inflammation - immunology Inflammation - metabolism Major depression disorder Male Middle Aged Monocytes - metabolism P2X7 receptors Receptors, Purinergic P2X7 - metabolism
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