Selective depletion of hepatic stellate cells‐specific LOXL1 alleviates liver fibrosis

The role of LOXL1 in fibrosis via mediating ECM crosslinking and stabilization is well established; however, the role of hepatic stellate cells (HSCs)‐specific LOXL1 in the development of fibrosis remains unknown. We generated HSCs‐specific Loxl1‐depleted mice (Loxl1Gfap‐cre mice) to investigate the...

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Veröffentlicht in:	The FASEB journal 2021-10, Vol.35 (10), p.e21918-n/a
Hauptverfasser:	Yang, Aiting, Yan, Xuzhen, Xu, Hufeng, Fan, Xu, Zhang, Mengyang, Huang, Tao, Li, Weiyu, Chen, Wei, Jia, Jidong, You, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	extracellular matrix hepatic stellate cells ITGA8 liver fibrosis LOXL1
Online-Zugang:	Volltext
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