Amyloid Beta-Peptide 25–35 (Aβ25–35) Induces Cytotoxicity via Multiple Mechanisms: Roles of the Inhibition of Glucosylceramide Synthase by Aβ25–35 and Its Protection by D609

Sphingolipids (SLs), such as ceramide, glucosylceramide (GlcCer), and sphingomyelin, play important roles in the normal development/functions of the brain and peripheral tissues. Disruption of SL homeostasis in cells/organelles, specifically up-regulation of ceramide, is involved in multiple disease...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2021/10/01, Vol.44(10), pp.1419-1426
Hauptverfasser:	Tang, Zhihui, Motoyoshi, Kaisei, Honda, Takuya, Nakamura, Hiroyuki, Murayama, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease ceramide-converting enzyme fibroblast sphingolipid sphingomyelin
Online-Zugang:	Volltext
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