Hesperidin Inhibits UVB-Induced VEGF Production and Angiogenesis via the Inhibition of PI3K/Akt Pathway in HR-1 Hairless Mice

Hesperidin is a citrus flavanone glycoside with potent anti-inflammatory effects that interferes with UVB-stimulated angiogenesis in skin, but its molecular mechanisms of action remain unclear. Here, we investigated the effects of hesperidin on UVB-induced angiogenesis in HR-1 hairless mice. We foun...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2021/10/01, Vol.44(10), pp.1492-1498
Hauptverfasser:	Kim, Ki Mo, Im, A-Rang, Lee, Joo Young, Kim, Taesoo, Ji, Kon-Young, Park, Dae-Hun, Chae, Sungwook
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Angiogenesis Animals Collagenase 3 Disease Models, Animal Fibroblasts Gelatinase B Hairless Hesperidin Hesperidin - pharmacology Hesperidin - therapeutic use Humans hypoxia inducible factor-1α Hypoxia-inducible factor 1 Immunohistochemistry Inflammation Keratinocytes Male Matrix metalloproteinase matrix metalloproteinase-9 (MMP-9) Metalloproteinase Mice Mice, Hairless Molecular modelling Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - etiology Neovascularization, Pathologic - pathology Phosphatidylinositol 3-Kinases - metabolism phosphoinositide 3-kinase Phosphorylation Phosphorylation - drug effects Primary Cell Culture Proto-Oncogene Proteins c-akt - metabolism Ribosomal Protein S6 Kinases, 70-kDa - metabolism Signal Transduction - drug effects Skin Skin - blood supply Skin - drug effects Skin - pathology Skin - radiation effects Ultraviolet radiation Ultraviolet Rays - adverse effects UVB light Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism Vascularization Western blotting
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