Proteomics Analysis of Lymphatic Metastasis-Related Proteins Using Highly Metastatic Human Melanoma Cells Originated by Sequential in Vivo Implantation

Metastasis of cancer cells to lymph nodes (LN) is a common modality of metastasis in clinical settings, but the mechanisms involved in lymphatic metastasis remain unclear compared to hematogenous metastasis to bones and the brain. To elucidate the molecular mechanisms responsible for melanoma LN met...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2021/10/01, Vol.44(10), pp.1551-1556
Hauptverfasser:	Chida, Katsuyuki, Sakurai, Yu, Ohtani, Asa, Masuda, Takeshi, Ohtsuki, Sumio, Tanaka, Hiroki, Akita, Hidetaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell adhesion Cell Adhesion - genetics Cell Line, Tumor Epithelial-Mesenchymal Transition - genetics epithelial-to-mesenchymal transition Gene Expression Regulation, Neoplastic Humans Lymph nodes Lymph Nodes - pathology lymphatic metastasis Lymphatic Metastasis - genetics Lymphatic Metastasis - pathology Male Melanoma Melanoma - genetics Melanoma - secondary Mesenchyme Metastases Metastasis Mice Molecular modelling Proteins Proteomics proteomics analysis Signal Transduction - genetics Skin Neoplasms - genetics Skin Neoplasms - pathology Transforming Growth Factor beta - metabolism Transforming growth factor-b Transplantation Xenograft Model Antitumor Assays
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