Analysis of the Intrahospital and Long-Term Survival of Heart Transplant Patients With a Short-Term Mechanical Assistance Device
•There are different risk subgroups in terms of mortality among patients transplanted with a circulatory/ventricular assist device.•The 2 highest risk groups were those who had extracorporeal membrane oxygenation >10 days before transplantation and patients with Levitronix Centrimag implantation...
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creator | López-Vilella, Raquel Sánchez-Lázaro, Ignacio Moncho, Azucena Pajares Peregrina, Mónica Talavera Guillén, Manuel Pérez Jáuregui, Iratxe Zarragoikoetxea Costa, Ricardo Gimeno Trenado, Víctor Donoso Dolz, Luis Martínez Puerta, Salvador Torregrosa Bonet, Luis Almenar |
description | •There are different risk subgroups in terms of mortality among patients transplanted with a circulatory/ventricular assist device.•The 2 highest risk groups were those who had extracorporeal membrane oxygenation >10 days before transplantation and patients with Levitronix Centrimag implantation who were classified as INTERMACS 2.•Orotracheal intubation before transplantation has a negative effect on survival.
The purpose of this study was to compare early and late survival among patients who have undergone heart transplantation (HTx) with a short-term mechanical assist device.
This was an ambispective, single-center, consecutive study of patients undergoing urgent HTx for 5 years. Pediatric transplants, retransplants, and combined transplants were excluded. Forty-five patients were included. Four groups were analyzed: those with venoarterial extracorporeal membrane oxygenation (ECMO) implanted 10 days; patients classified as INTERMACS 2 to 3 with Levitronix Centrimag implanted; and those classified as INTERMACS 2 with Levitronix Centrimag implanted. Survival and the influence of orotracheal intubation (OI) at the time of transplantation were compared.
There were differences in in-hospital mortality (P = .03) and total mortality (P = .06). The groups with the highest risk for mortality were those who carried ECMO for >10 days before transplantation or those classified as INTERMACS 2 with Levitronix Centrimag implanted. In these groups, the need for posttransplant circulatory support was also greater (P = .04) as was the length of stay in critical care (P = .02). The need for OI during the days of care and until transplantation had a negative effect on survival in all groups (P < .1).
There are different risk subgroups among patients who are transplanted with a circulatory/ventricular assist device. The lowest mortality occurs when the days of ECMO implantation are |
doi_str_mv | 10.1016/j.transproceed.2021.06.030 |
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The purpose of this study was to compare early and late survival among patients who have undergone heart transplantation (HTx) with a short-term mechanical assist device.
This was an ambispective, single-center, consecutive study of patients undergoing urgent HTx for 5 years. Pediatric transplants, retransplants, and combined transplants were excluded. Forty-five patients were included. Four groups were analyzed: those with venoarterial extracorporeal membrane oxygenation (ECMO) implanted <10 days before HTx; those with ECMO implanted for >10 days; patients classified as INTERMACS 2 to 3 with Levitronix Centrimag implanted; and those classified as INTERMACS 2 with Levitronix Centrimag implanted. Survival and the influence of orotracheal intubation (OI) at the time of transplantation were compared.
There were differences in in-hospital mortality (P = .03) and total mortality (P = .06). The groups with the highest risk for mortality were those who carried ECMO for >10 days before transplantation or those classified as INTERMACS 2 with Levitronix Centrimag implanted. In these groups, the need for posttransplant circulatory support was also greater (P = .04) as was the length of stay in critical care (P = .02). The need for OI during the days of care and until transplantation had a negative effect on survival in all groups (P < .1).
There are different risk subgroups among patients who are transplanted with a circulatory/ventricular assist device. The lowest mortality occurs when the days of ECMO implantation are <10 and when the implanted device is a Levitronix Centrimag in INTERMACS 2 to 3 profile, particularly when the patient reaches the HTx without requiring OI.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2021.06.030</identifier><language>eng</language><publisher>Elsevier Inc</publisher><ispartof>Transplantation proceedings, 2021-11, Vol.53 (9), p.2728-2730</ispartof><rights>2021 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-566648d2a60c00c1fae10679a8507123025329a133603680cdd765f6318ea0683</cites><orcidid>0000-0001-5145-8191 ; 0000-0003-3740-6154 ; 0000-0003-2851-4153</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2021.06.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>López-Vilella, Raquel</creatorcontrib><creatorcontrib>Sánchez-Lázaro, Ignacio</creatorcontrib><creatorcontrib>Moncho, Azucena Pajares</creatorcontrib><creatorcontrib>Peregrina, Mónica Talavera</creatorcontrib><creatorcontrib>Guillén, Manuel Pérez</creatorcontrib><creatorcontrib>Jáuregui, Iratxe Zarragoikoetxea</creatorcontrib><creatorcontrib>Costa, Ricardo Gimeno</creatorcontrib><creatorcontrib>Trenado, Víctor Donoso</creatorcontrib><creatorcontrib>Dolz, Luis Martínez</creatorcontrib><creatorcontrib>Puerta, Salvador Torregrosa</creatorcontrib><creatorcontrib>Bonet, Luis Almenar</creatorcontrib><title>Analysis of the Intrahospital and Long-Term Survival of Heart Transplant Patients With a Short-Term Mechanical Assistance Device</title><title>Transplantation proceedings</title><description>•There are different risk subgroups in terms of mortality among patients transplanted with a circulatory/ventricular assist device.•The 2 highest risk groups were those who had extracorporeal membrane oxygenation >10 days before transplantation and patients with Levitronix Centrimag implantation who were classified as INTERMACS 2.•Orotracheal intubation before transplantation has a negative effect on survival.
The purpose of this study was to compare early and late survival among patients who have undergone heart transplantation (HTx) with a short-term mechanical assist device.
This was an ambispective, single-center, consecutive study of patients undergoing urgent HTx for 5 years. Pediatric transplants, retransplants, and combined transplants were excluded. Forty-five patients were included. Four groups were analyzed: those with venoarterial extracorporeal membrane oxygenation (ECMO) implanted <10 days before HTx; those with ECMO implanted for >10 days; patients classified as INTERMACS 2 to 3 with Levitronix Centrimag implanted; and those classified as INTERMACS 2 with Levitronix Centrimag implanted. Survival and the influence of orotracheal intubation (OI) at the time of transplantation were compared.
There were differences in in-hospital mortality (P = .03) and total mortality (P = .06). The groups with the highest risk for mortality were those who carried ECMO for >10 days before transplantation or those classified as INTERMACS 2 with Levitronix Centrimag implanted. In these groups, the need for posttransplant circulatory support was also greater (P = .04) as was the length of stay in critical care (P = .02). The need for OI during the days of care and until transplantation had a negative effect on survival in all groups (P < .1).
There are different risk subgroups among patients who are transplanted with a circulatory/ventricular assist device. The lowest mortality occurs when the days of ECMO implantation are <10 and when the implanted device is a Levitronix Centrimag in INTERMACS 2 to 3 profile, particularly when the patient reaches the HTx without requiring OI.</description><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNkEFPGzEQhS1UJFLKf7B66mWXsZ31Lr1FUEikIJAI4miNvLOso403tZ2VuPWnY5oeeuQ0mtF7b2Y-xr4LKAUIfbktU0Af92G0RG0pQYoSdAkKTthMNLUqpJbqC5sBzEUh1Lw6Y19j3ELu5VzN2J-Fx-EtusjHjqee-MrnxH6Me5dw4Ohbvh79a7GhsONPhzC5KY-zdkkYEt_83T6gT_wRkyOfIn9xqefIn_oxpKPvnmyP3tnsXMS8K6G3xG9ocpa-sdMOh0gX_-o5e779tbleFuuHu9X1Yl1YBZCKSms9b1qJGiyAFR2SAF1fYVNBLaQCWSl5hUIpDUo3YNu21lWnlWgIQTfqnP045mZWvw8Uk9m5aGnIt9N4iEZWdVPXjZKQpT-PUhvGGAN1Zh_cDsObEWA-sJut-R-7-cBuQJuMPZtvjmbKz0yOgok2c7HUukA2mXZ0n4l5B4vwkps</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>López-Vilella, Raquel</creator><creator>Sánchez-Lázaro, Ignacio</creator><creator>Moncho, Azucena Pajares</creator><creator>Peregrina, Mónica Talavera</creator><creator>Guillén, Manuel Pérez</creator><creator>Jáuregui, Iratxe Zarragoikoetxea</creator><creator>Costa, Ricardo Gimeno</creator><creator>Trenado, Víctor Donoso</creator><creator>Dolz, Luis Martínez</creator><creator>Puerta, Salvador Torregrosa</creator><creator>Bonet, Luis Almenar</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5145-8191</orcidid><orcidid>https://orcid.org/0000-0003-3740-6154</orcidid><orcidid>https://orcid.org/0000-0003-2851-4153</orcidid></search><sort><creationdate>202111</creationdate><title>Analysis of the Intrahospital and Long-Term Survival of Heart Transplant Patients With a Short-Term Mechanical Assistance Device</title><author>López-Vilella, Raquel ; Sánchez-Lázaro, Ignacio ; Moncho, Azucena Pajares ; Peregrina, Mónica Talavera ; Guillén, Manuel Pérez ; Jáuregui, Iratxe Zarragoikoetxea ; Costa, Ricardo Gimeno ; Trenado, Víctor Donoso ; Dolz, Luis Martínez ; Puerta, Salvador Torregrosa ; Bonet, Luis Almenar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-566648d2a60c00c1fae10679a8507123025329a133603680cdd765f6318ea0683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López-Vilella, Raquel</creatorcontrib><creatorcontrib>Sánchez-Lázaro, Ignacio</creatorcontrib><creatorcontrib>Moncho, Azucena Pajares</creatorcontrib><creatorcontrib>Peregrina, Mónica Talavera</creatorcontrib><creatorcontrib>Guillén, Manuel Pérez</creatorcontrib><creatorcontrib>Jáuregui, Iratxe Zarragoikoetxea</creatorcontrib><creatorcontrib>Costa, Ricardo Gimeno</creatorcontrib><creatorcontrib>Trenado, Víctor Donoso</creatorcontrib><creatorcontrib>Dolz, Luis Martínez</creatorcontrib><creatorcontrib>Puerta, Salvador Torregrosa</creatorcontrib><creatorcontrib>Bonet, Luis Almenar</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>López-Vilella, Raquel</au><au>Sánchez-Lázaro, Ignacio</au><au>Moncho, Azucena Pajares</au><au>Peregrina, Mónica Talavera</au><au>Guillén, Manuel Pérez</au><au>Jáuregui, Iratxe Zarragoikoetxea</au><au>Costa, Ricardo Gimeno</au><au>Trenado, Víctor Donoso</au><au>Dolz, Luis Martínez</au><au>Puerta, Salvador Torregrosa</au><au>Bonet, Luis Almenar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the Intrahospital and Long-Term Survival of Heart Transplant Patients With a Short-Term Mechanical Assistance Device</atitle><jtitle>Transplantation proceedings</jtitle><date>2021-11</date><risdate>2021</risdate><volume>53</volume><issue>9</issue><spage>2728</spage><epage>2730</epage><pages>2728-2730</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><abstract>•There are different risk subgroups in terms of mortality among patients transplanted with a circulatory/ventricular assist device.•The 2 highest risk groups were those who had extracorporeal membrane oxygenation >10 days before transplantation and patients with Levitronix Centrimag implantation who were classified as INTERMACS 2.•Orotracheal intubation before transplantation has a negative effect on survival.
The purpose of this study was to compare early and late survival among patients who have undergone heart transplantation (HTx) with a short-term mechanical assist device.
This was an ambispective, single-center, consecutive study of patients undergoing urgent HTx for 5 years. Pediatric transplants, retransplants, and combined transplants were excluded. Forty-five patients were included. Four groups were analyzed: those with venoarterial extracorporeal membrane oxygenation (ECMO) implanted <10 days before HTx; those with ECMO implanted for >10 days; patients classified as INTERMACS 2 to 3 with Levitronix Centrimag implanted; and those classified as INTERMACS 2 with Levitronix Centrimag implanted. Survival and the influence of orotracheal intubation (OI) at the time of transplantation were compared.
There were differences in in-hospital mortality (P = .03) and total mortality (P = .06). The groups with the highest risk for mortality were those who carried ECMO for >10 days before transplantation or those classified as INTERMACS 2 with Levitronix Centrimag implanted. In these groups, the need for posttransplant circulatory support was also greater (P = .04) as was the length of stay in critical care (P = .02). The need for OI during the days of care and until transplantation had a negative effect on survival in all groups (P < .1).
There are different risk subgroups among patients who are transplanted with a circulatory/ventricular assist device. The lowest mortality occurs when the days of ECMO implantation are <10 and when the implanted device is a Levitronix Centrimag in INTERMACS 2 to 3 profile, particularly when the patient reaches the HTx without requiring OI.</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.transproceed.2021.06.030</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0001-5145-8191</orcidid><orcidid>https://orcid.org/0000-0003-3740-6154</orcidid><orcidid>https://orcid.org/0000-0003-2851-4153</orcidid></addata></record> |
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title | Analysis of the Intrahospital and Long-Term Survival of Heart Transplant Patients With a Short-Term Mechanical Assistance Device |
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