Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin
Purpose The purpose of this study was to analyse the effects of demographic factors, clinical factors, and genetic polymorphisms of related gene loci on warfarin bleeding-related complications in the Han population. Methods Retrospective medical record review. The study cases were patients treated a...
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| Veröffentlicht in: | European journal of clinical pharmacology 2022-02, Vol.78 (2), p.205-214 |
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| creator | Xia, Xiaotong Fu, Jinglan Wu, Tingting Chen, Wenjun Jiang, Shaojun Lv, Meina Zhang, Jinhua |
| description | Purpose
The purpose of this study was to analyse the effects of demographic factors, clinical factors, and genetic polymorphisms of related gene loci on warfarin bleeding-related complications in the Han population.
Methods
Retrospective medical record review. The study cases were patients treated at the Fujian Medical University Union Hospital from March 2016 to February 2020, and all received regular warfarin anticoagulation treatment for at least 3 months, and were provided the initial standard dose and stable dose of warfarin.
Results
Data were collected from 451 qualifying patients (47% male, 53% female). The average age of patients was 53.8 ± 12.2 years, and the average body surface area was 1.6 ± 0.18 m
2
. There were nine major bleeding events and 141 minor bleeding events. In the univariate logistic analysis, the
p
-value of the four factors body weight, body surface area (BSA), amiodarone, and
rs429358
was |
| doi_str_mv | 10.1007/s00228-021-03204-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2578777633</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2578777633</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-8c2f04e19e8cb3854c97c9f0bd8e229dea2f88c4519acedd83368adfa2765523</originalsourceid><addsrcrecordid>eNp9kMFq3DAQhkVISbZJXiCHIsilFzcjybLkY1jSphDIJdcitPJoV6ktuZKXsm8fb3bbQA89Dcx888_wEXLN4AsDULcFgHNdAWcVCA51tTshC1YLXjGo2SlZAAhWNa2Cc_KxlBcAJlsQZ-Rc1LJtFFcL8uPee3QTTZ6uMSIdU78bUh43oQw0RbrqEbsQ19SlYeyDs1NIsdAQ6XITIhakDzbScW5jnAqd7M89_Ntmb3OIl-SDt33Bq2O9IM9f75-XD9Xj07fvy7vHygklp0o77qFG1qJ2K6Fl7VrlWg-rTiPnbYeWe61dLVlrHXadFqLRtvOWq0ZKLi7I50PsmNOvLZbJDKE47HsbMW2L4VJppVQjxIze_IO-pG2O83OGN0wLXTO5p_iBcjmVktGbMYfB5p1hYPbuzcG9md2bN_dmNy99OkZvVwN2f1f-yJ4BcQDKPIprzO-3_xP7CiCLkBc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2618384153</pqid></control><display><type>article</type><title>Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Xia, Xiaotong ; Fu, Jinglan ; Wu, Tingting ; Chen, Wenjun ; Jiang, Shaojun ; Lv, Meina ; Zhang, Jinhua</creator><creatorcontrib>Xia, Xiaotong ; Fu, Jinglan ; Wu, Tingting ; Chen, Wenjun ; Jiang, Shaojun ; Lv, Meina ; Zhang, Jinhua</creatorcontrib><description>Purpose
The purpose of this study was to analyse the effects of demographic factors, clinical factors, and genetic polymorphisms of related gene loci on warfarin bleeding-related complications in the Han population.
Methods
Retrospective medical record review. The study cases were patients treated at the Fujian Medical University Union Hospital from March 2016 to February 2020, and all received regular warfarin anticoagulation treatment for at least 3 months, and were provided the initial standard dose and stable dose of warfarin.
Results
Data were collected from 451 qualifying patients (47% male, 53% female). The average age of patients was 53.8 ± 12.2 years, and the average body surface area was 1.6 ± 0.18 m
2
. There were nine major bleeding events and 141 minor bleeding events. In the univariate logistic analysis, the
p
-value of the four factors body weight, body surface area (BSA), amiodarone, and
rs429358
was < 0.10. However, the final
p
-values for amiodarone and
rs429358
were < 0.05 in the multifactorial logistic analysis.
Conclusions
The
ApoE
(
rs429358
) gene polymorphism influences bleeding complications in Chinese Han patients treated with warfarin. The sample size of this study was relatively small; hence an international study with a larger sample size is needed in the future.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s00228-021-03204-y</identifier><identifier>PMID: 34596727</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Amiodarone ; Amiodarone - pharmacology ; Anti-Arrhythmia Agents - pharmacology ; Anticoagulants ; Anticoagulants - adverse effects ; Apolipoprotein E ; Apolipoproteins E - genetics ; Asians - genetics ; Biomedical and Life Sciences ; Biomedicine ; Bleeding ; Body Surface Area ; Body Weight ; China ; Cytochrome P-450 Enzyme Inhibitors - pharmacology ; Ethnicity ; Female ; Gene polymorphism ; Genotype ; Hemorrhage - chemically induced ; Humans ; International Normalized Ratio ; Male ; Middle Aged ; Patients ; Pharmacogenetics ; Pharmacology/Toxicology ; Polymorphism ; Polymorphism, Single Nucleotide ; Retrospective Studies ; Sociodemographic Factors ; Surface area ; Warfarin ; Warfarin - adverse effects</subject><ispartof>European journal of clinical pharmacology, 2022-02, Vol.78 (2), p.205-214</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-8c2f04e19e8cb3854c97c9f0bd8e229dea2f88c4519acedd83368adfa2765523</citedby><cites>FETCH-LOGICAL-c375t-8c2f04e19e8cb3854c97c9f0bd8e229dea2f88c4519acedd83368adfa2765523</cites><orcidid>0000-0002-5629-0348</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00228-021-03204-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00228-021-03204-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34596727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xia, Xiaotong</creatorcontrib><creatorcontrib>Fu, Jinglan</creatorcontrib><creatorcontrib>Wu, Tingting</creatorcontrib><creatorcontrib>Chen, Wenjun</creatorcontrib><creatorcontrib>Jiang, Shaojun</creatorcontrib><creatorcontrib>Lv, Meina</creatorcontrib><creatorcontrib>Zhang, Jinhua</creatorcontrib><title>Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><addtitle>Eur J Clin Pharmacol</addtitle><description>Purpose
The purpose of this study was to analyse the effects of demographic factors, clinical factors, and genetic polymorphisms of related gene loci on warfarin bleeding-related complications in the Han population.
Methods
Retrospective medical record review. The study cases were patients treated at the Fujian Medical University Union Hospital from March 2016 to February 2020, and all received regular warfarin anticoagulation treatment for at least 3 months, and were provided the initial standard dose and stable dose of warfarin.
Results
Data were collected from 451 qualifying patients (47% male, 53% female). The average age of patients was 53.8 ± 12.2 years, and the average body surface area was 1.6 ± 0.18 m
2
. There were nine major bleeding events and 141 minor bleeding events. In the univariate logistic analysis, the
p
-value of the four factors body weight, body surface area (BSA), amiodarone, and
rs429358
was < 0.10. However, the final
p
-values for amiodarone and
rs429358
were < 0.05 in the multifactorial logistic analysis.
Conclusions
The
ApoE
(
rs429358
) gene polymorphism influences bleeding complications in Chinese Han patients treated with warfarin. The sample size of this study was relatively small; hence an international study with a larger sample size is needed in the future.</description><subject>Adult</subject><subject>Aged</subject><subject>Amiodarone</subject><subject>Amiodarone - pharmacology</subject><subject>Anti-Arrhythmia Agents - pharmacology</subject><subject>Anticoagulants</subject><subject>Anticoagulants - adverse effects</subject><subject>Apolipoprotein E</subject><subject>Apolipoproteins E - genetics</subject><subject>Asians - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bleeding</subject><subject>Body Surface Area</subject><subject>Body Weight</subject><subject>China</subject><subject>Cytochrome P-450 Enzyme Inhibitors - pharmacology</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genotype</subject><subject>Hemorrhage - chemically induced</subject><subject>Humans</subject><subject>International Normalized Ratio</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Pharmacogenetics</subject><subject>Pharmacology/Toxicology</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Retrospective Studies</subject><subject>Sociodemographic Factors</subject><subject>Surface area</subject><subject>Warfarin</subject><subject>Warfarin - adverse effects</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kMFq3DAQhkVISbZJXiCHIsilFzcjybLkY1jSphDIJdcitPJoV6ktuZKXsm8fb3bbQA89Dcx888_wEXLN4AsDULcFgHNdAWcVCA51tTshC1YLXjGo2SlZAAhWNa2Cc_KxlBcAJlsQZ-Rc1LJtFFcL8uPee3QTTZ6uMSIdU78bUh43oQw0RbrqEbsQ19SlYeyDs1NIsdAQ6XITIhakDzbScW5jnAqd7M89_Ntmb3OIl-SDt33Bq2O9IM9f75-XD9Xj07fvy7vHygklp0o77qFG1qJ2K6Fl7VrlWg-rTiPnbYeWe61dLVlrHXadFqLRtvOWq0ZKLi7I50PsmNOvLZbJDKE47HsbMW2L4VJppVQjxIze_IO-pG2O83OGN0wLXTO5p_iBcjmVktGbMYfB5p1hYPbuzcG9md2bN_dmNy99OkZvVwN2f1f-yJ4BcQDKPIprzO-3_xP7CiCLkBc</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Xia, Xiaotong</creator><creator>Fu, Jinglan</creator><creator>Wu, Tingting</creator><creator>Chen, Wenjun</creator><creator>Jiang, Shaojun</creator><creator>Lv, Meina</creator><creator>Zhang, Jinhua</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5629-0348</orcidid></search><sort><creationdate>20220201</creationdate><title>Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin</title><author>Xia, Xiaotong ; Fu, Jinglan ; Wu, Tingting ; Chen, Wenjun ; Jiang, Shaojun ; Lv, Meina ; Zhang, Jinhua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-8c2f04e19e8cb3854c97c9f0bd8e229dea2f88c4519acedd83368adfa2765523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amiodarone</topic><topic>Amiodarone - pharmacology</topic><topic>Anti-Arrhythmia Agents - pharmacology</topic><topic>Anticoagulants</topic><topic>Anticoagulants - adverse effects</topic><topic>Apolipoprotein E</topic><topic>Apolipoproteins E - genetics</topic><topic>Asians - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bleeding</topic><topic>Body Surface Area</topic><topic>Body Weight</topic><topic>China</topic><topic>Cytochrome P-450 Enzyme Inhibitors - pharmacology</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genotype</topic><topic>Hemorrhage - chemically induced</topic><topic>Humans</topic><topic>International Normalized Ratio</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Pharmacogenetics</topic><topic>Pharmacology/Toxicology</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Retrospective Studies</topic><topic>Sociodemographic Factors</topic><topic>Surface area</topic><topic>Warfarin</topic><topic>Warfarin - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xia, Xiaotong</creatorcontrib><creatorcontrib>Fu, Jinglan</creatorcontrib><creatorcontrib>Wu, Tingting</creatorcontrib><creatorcontrib>Chen, Wenjun</creatorcontrib><creatorcontrib>Jiang, Shaojun</creatorcontrib><creatorcontrib>Lv, Meina</creatorcontrib><creatorcontrib>Zhang, Jinhua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xia, Xiaotong</au><au>Fu, Jinglan</au><au>Wu, Tingting</au><au>Chen, Wenjun</au><au>Jiang, Shaojun</au><au>Lv, Meina</au><au>Zhang, Jinhua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin</atitle><jtitle>European journal of clinical pharmacology</jtitle><stitle>Eur J Clin Pharmacol</stitle><addtitle>Eur J Clin Pharmacol</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>78</volume><issue>2</issue><spage>205</spage><epage>214</epage><pages>205-214</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Purpose
The purpose of this study was to analyse the effects of demographic factors, clinical factors, and genetic polymorphisms of related gene loci on warfarin bleeding-related complications in the Han population.
Methods
Retrospective medical record review. The study cases were patients treated at the Fujian Medical University Union Hospital from March 2016 to February 2020, and all received regular warfarin anticoagulation treatment for at least 3 months, and were provided the initial standard dose and stable dose of warfarin.
Results
Data were collected from 451 qualifying patients (47% male, 53% female). The average age of patients was 53.8 ± 12.2 years, and the average body surface area was 1.6 ± 0.18 m
2
. There were nine major bleeding events and 141 minor bleeding events. In the univariate logistic analysis, the
p
-value of the four factors body weight, body surface area (BSA), amiodarone, and
rs429358
was < 0.10. However, the final
p
-values for amiodarone and
rs429358
were < 0.05 in the multifactorial logistic analysis.
Conclusions
The
ApoE
(
rs429358
) gene polymorphism influences bleeding complications in Chinese Han patients treated with warfarin. The sample size of this study was relatively small; hence an international study with a larger sample size is needed in the future.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34596727</pmid><doi>10.1007/s00228-021-03204-y</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5629-0348</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 2022-02, Vol.78 (2), p.205-214 |
| issn | 0031-6970 1432-1041 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2578777633 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Amiodarone Amiodarone - pharmacology Anti-Arrhythmia Agents - pharmacology Anticoagulants Anticoagulants - adverse effects Apolipoprotein E Apolipoproteins E - genetics Asians - genetics Biomedical and Life Sciences Biomedicine Bleeding Body Surface Area Body Weight China Cytochrome P-450 Enzyme Inhibitors - pharmacology Ethnicity Female Gene polymorphism Genotype Hemorrhage - chemically induced Humans International Normalized Ratio Male Middle Aged Patients Pharmacogenetics Pharmacology/Toxicology Polymorphism Polymorphism, Single Nucleotide Retrospective Studies Sociodemographic Factors Surface area Warfarin Warfarin - adverse effects |
| title | Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin |
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