Influence of Cytomegalovirus on the Survival of Cytomegalovirus-Seropositive Lung Transplant

•The incidence of cytomegalovirus events in the study sample was 36.8% despite routine 6-month prophylaxis.•In patients with positive cytomegalovirus serology, the development of cytomegalovirus events, including severe cases, does not seem to influence survival.•In the present sample, cytomegalovir...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Transplantation proceedings 2021-11, Vol.53 (9), p.2734-2738
Hauptverfasser: Revuelta-Salgado, Fernando, Margallo-Iribarnegaray, Juan, De Pablo-Gafas, Alicia, Alonso-Moralejo, Rodrigo, Quezada-Loaiza, Carlos Andrés, Pérez-González, Virginia Luz
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 2738
container_issue 9
container_start_page 2734
container_title Transplantation proceedings
container_volume 53
creator Revuelta-Salgado, Fernando
Margallo-Iribarnegaray, Juan
De Pablo-Gafas, Alicia
Alonso-Moralejo, Rodrigo
Quezada-Loaiza, Carlos Andrés
Pérez-González, Virginia Luz
description •The incidence of cytomegalovirus events in the study sample was 36.8% despite routine 6-month prophylaxis.•In patients with positive cytomegalovirus serology, the development of cytomegalovirus events, including severe cases, does not seem to influence survival.•In the present sample, cytomegalovirus is not a cause of death in any of the patients.•The incidence of chronic lung allograft dysfunction is not increased by the presence of cytomegalovirus events. The primary aim of this study was to analyze the survival of patients undergoing lung transplant (LT) with cytomegalovirus (CMV)-positive serologies at the time of transplantation, according to the presence of CMV events and according to the severity of these events. The secondary objective was to assess whether there are differences in the incidence of chronic lung allograft dysfunction (CLAD) according to the presence of these events. This was an observational, single-center, retrospective study. The inclusion criterion for the study was having undergone LT at the Hospital Universitario 12 de Octubre from October 2008 to February 2019. Survival was calculated using the Kaplan-Meier method and compared using the log-rank test. The incidence of CLAD was compared using the χ2 test. Inclusion criteria were met by 239 LTs. In terms of survival, no difference was found between patients with and without CMV events (log-rank P = .52), with mean survival of 3223 ± 164 days and 3024 ± 146 days, respectively. Nor did we find a difference when stratifying patients according to no CMV events, infection, syndrome, and disease (log-rank P = .6). There was also no difference in the incidence of CLAD between patients with and without CMV events (P > .178). In patients with positive CMV serology, the development of CMV events, including severe disease, does not seem to influence survival. The incidence of CLAD also is not increased by the presence of CMV events.
doi_str_mv 10.1016/j.transproceed.2021.08.043
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2578774737</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S004113452100631X</els_id><sourcerecordid>2578774737</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-4d85991fa30c97ab7b75ff05a8de56f018c18758607008e5e3745afc5547294b3</originalsourceid><addsrcrecordid>eNqNkD9PwzAUxC0EEqXwHSImloTn2K4dNlT-SpUYChuS5TrP4CqNi51E4tuTUgYGBqanJ92d7n6EnFMoKNDZ5broomnTNgaLWBcllLQAVQBnB2RClWR5OSvZIZkAcJpTxsUxOUlpDeNfcjYhr4-ta3psLWbBZfPPLmzwzTRh8LFPWWiz7h2zZR8HP5jmD0m-xBi2IfnOD5gt-vYte_5u1Ji2OyVHzjQJz37ulLzc3T7PH_LF0_3j_HqRWwbQ5bxWoqqoMwxsJc1KrqRwDoRRNYqZA6rsOEWoGUgAhQKZ5MI4KwSXZcVXbEou9rkjh48eU6c3Pllsxg4Y-qRLIZWUXDI5Sq_2UhtDShGd3ka_MfFTU9A7pHqtfyPVO6QalB6RjuabvRnHMYPHqJP1O3a1j2g7XQf_n5gvClyIMA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2578774737</pqid></control><display><type>article</type><title>Influence of Cytomegalovirus on the Survival of Cytomegalovirus-Seropositive Lung Transplant</title><source>ScienceDirect Freedom Collection (Elsevier)</source><creator>Revuelta-Salgado, Fernando ; Margallo-Iribarnegaray, Juan ; De Pablo-Gafas, Alicia ; Alonso-Moralejo, Rodrigo ; Quezada-Loaiza, Carlos Andrés ; Pérez-González, Virginia Luz</creator><creatorcontrib>Revuelta-Salgado, Fernando ; Margallo-Iribarnegaray, Juan ; De Pablo-Gafas, Alicia ; Alonso-Moralejo, Rodrigo ; Quezada-Loaiza, Carlos Andrés ; Pérez-González, Virginia Luz</creatorcontrib><description>•The incidence of cytomegalovirus events in the study sample was 36.8% despite routine 6-month prophylaxis.•In patients with positive cytomegalovirus serology, the development of cytomegalovirus events, including severe cases, does not seem to influence survival.•In the present sample, cytomegalovirus is not a cause of death in any of the patients.•The incidence of chronic lung allograft dysfunction is not increased by the presence of cytomegalovirus events. The primary aim of this study was to analyze the survival of patients undergoing lung transplant (LT) with cytomegalovirus (CMV)-positive serologies at the time of transplantation, according to the presence of CMV events and according to the severity of these events. The secondary objective was to assess whether there are differences in the incidence of chronic lung allograft dysfunction (CLAD) according to the presence of these events. This was an observational, single-center, retrospective study. The inclusion criterion for the study was having undergone LT at the Hospital Universitario 12 de Octubre from October 2008 to February 2019. Survival was calculated using the Kaplan-Meier method and compared using the log-rank test. The incidence of CLAD was compared using the χ2 test. Inclusion criteria were met by 239 LTs. In terms of survival, no difference was found between patients with and without CMV events (log-rank P = .52), with mean survival of 3223 ± 164 days and 3024 ± 146 days, respectively. Nor did we find a difference when stratifying patients according to no CMV events, infection, syndrome, and disease (log-rank P = .6). There was also no difference in the incidence of CLAD between patients with and without CMV events (P &gt; .178). In patients with positive CMV serology, the development of CMV events, including severe disease, does not seem to influence survival. The incidence of CLAD also is not increased by the presence of CMV events.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2021.08.043</identifier><language>eng</language><publisher>Elsevier Inc</publisher><ispartof>Transplantation proceedings, 2021-11, Vol.53 (9), p.2734-2738</ispartof><rights>2021 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-4d85991fa30c97ab7b75ff05a8de56f018c18758607008e5e3745afc5547294b3</cites><orcidid>0000-0002-1743-2964</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2021.08.043$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Revuelta-Salgado, Fernando</creatorcontrib><creatorcontrib>Margallo-Iribarnegaray, Juan</creatorcontrib><creatorcontrib>De Pablo-Gafas, Alicia</creatorcontrib><creatorcontrib>Alonso-Moralejo, Rodrigo</creatorcontrib><creatorcontrib>Quezada-Loaiza, Carlos Andrés</creatorcontrib><creatorcontrib>Pérez-González, Virginia Luz</creatorcontrib><title>Influence of Cytomegalovirus on the Survival of Cytomegalovirus-Seropositive Lung Transplant</title><title>Transplantation proceedings</title><description>•The incidence of cytomegalovirus events in the study sample was 36.8% despite routine 6-month prophylaxis.•In patients with positive cytomegalovirus serology, the development of cytomegalovirus events, including severe cases, does not seem to influence survival.•In the present sample, cytomegalovirus is not a cause of death in any of the patients.•The incidence of chronic lung allograft dysfunction is not increased by the presence of cytomegalovirus events. The primary aim of this study was to analyze the survival of patients undergoing lung transplant (LT) with cytomegalovirus (CMV)-positive serologies at the time of transplantation, according to the presence of CMV events and according to the severity of these events. The secondary objective was to assess whether there are differences in the incidence of chronic lung allograft dysfunction (CLAD) according to the presence of these events. This was an observational, single-center, retrospective study. The inclusion criterion for the study was having undergone LT at the Hospital Universitario 12 de Octubre from October 2008 to February 2019. Survival was calculated using the Kaplan-Meier method and compared using the log-rank test. The incidence of CLAD was compared using the χ2 test. Inclusion criteria were met by 239 LTs. In terms of survival, no difference was found between patients with and without CMV events (log-rank P = .52), with mean survival of 3223 ± 164 days and 3024 ± 146 days, respectively. Nor did we find a difference when stratifying patients according to no CMV events, infection, syndrome, and disease (log-rank P = .6). There was also no difference in the incidence of CLAD between patients with and without CMV events (P &gt; .178). In patients with positive CMV serology, the development of CMV events, including severe disease, does not seem to influence survival. The incidence of CLAD also is not increased by the presence of CMV events.</description><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNkD9PwzAUxC0EEqXwHSImloTn2K4dNlT-SpUYChuS5TrP4CqNi51E4tuTUgYGBqanJ92d7n6EnFMoKNDZ5broomnTNgaLWBcllLQAVQBnB2RClWR5OSvZIZkAcJpTxsUxOUlpDeNfcjYhr4-ta3psLWbBZfPPLmzwzTRh8LFPWWiz7h2zZR8HP5jmD0m-xBi2IfnOD5gt-vYte_5u1Ji2OyVHzjQJz37ulLzc3T7PH_LF0_3j_HqRWwbQ5bxWoqqoMwxsJc1KrqRwDoRRNYqZA6rsOEWoGUgAhQKZ5MI4KwSXZcVXbEou9rkjh48eU6c3Pllsxg4Y-qRLIZWUXDI5Sq_2UhtDShGd3ka_MfFTU9A7pHqtfyPVO6QalB6RjuabvRnHMYPHqJP1O3a1j2g7XQf_n5gvClyIMA</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Revuelta-Salgado, Fernando</creator><creator>Margallo-Iribarnegaray, Juan</creator><creator>De Pablo-Gafas, Alicia</creator><creator>Alonso-Moralejo, Rodrigo</creator><creator>Quezada-Loaiza, Carlos Andrés</creator><creator>Pérez-González, Virginia Luz</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1743-2964</orcidid></search><sort><creationdate>202111</creationdate><title>Influence of Cytomegalovirus on the Survival of Cytomegalovirus-Seropositive Lung Transplant</title><author>Revuelta-Salgado, Fernando ; Margallo-Iribarnegaray, Juan ; De Pablo-Gafas, Alicia ; Alonso-Moralejo, Rodrigo ; Quezada-Loaiza, Carlos Andrés ; Pérez-González, Virginia Luz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-4d85991fa30c97ab7b75ff05a8de56f018c18758607008e5e3745afc5547294b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Revuelta-Salgado, Fernando</creatorcontrib><creatorcontrib>Margallo-Iribarnegaray, Juan</creatorcontrib><creatorcontrib>De Pablo-Gafas, Alicia</creatorcontrib><creatorcontrib>Alonso-Moralejo, Rodrigo</creatorcontrib><creatorcontrib>Quezada-Loaiza, Carlos Andrés</creatorcontrib><creatorcontrib>Pérez-González, Virginia Luz</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Revuelta-Salgado, Fernando</au><au>Margallo-Iribarnegaray, Juan</au><au>De Pablo-Gafas, Alicia</au><au>Alonso-Moralejo, Rodrigo</au><au>Quezada-Loaiza, Carlos Andrés</au><au>Pérez-González, Virginia Luz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Cytomegalovirus on the Survival of Cytomegalovirus-Seropositive Lung Transplant</atitle><jtitle>Transplantation proceedings</jtitle><date>2021-11</date><risdate>2021</risdate><volume>53</volume><issue>9</issue><spage>2734</spage><epage>2738</epage><pages>2734-2738</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><abstract>•The incidence of cytomegalovirus events in the study sample was 36.8% despite routine 6-month prophylaxis.•In patients with positive cytomegalovirus serology, the development of cytomegalovirus events, including severe cases, does not seem to influence survival.•In the present sample, cytomegalovirus is not a cause of death in any of the patients.•The incidence of chronic lung allograft dysfunction is not increased by the presence of cytomegalovirus events. The primary aim of this study was to analyze the survival of patients undergoing lung transplant (LT) with cytomegalovirus (CMV)-positive serologies at the time of transplantation, according to the presence of CMV events and according to the severity of these events. The secondary objective was to assess whether there are differences in the incidence of chronic lung allograft dysfunction (CLAD) according to the presence of these events. This was an observational, single-center, retrospective study. The inclusion criterion for the study was having undergone LT at the Hospital Universitario 12 de Octubre from October 2008 to February 2019. Survival was calculated using the Kaplan-Meier method and compared using the log-rank test. The incidence of CLAD was compared using the χ2 test. Inclusion criteria were met by 239 LTs. In terms of survival, no difference was found between patients with and without CMV events (log-rank P = .52), with mean survival of 3223 ± 164 days and 3024 ± 146 days, respectively. Nor did we find a difference when stratifying patients according to no CMV events, infection, syndrome, and disease (log-rank P = .6). There was also no difference in the incidence of CLAD between patients with and without CMV events (P &gt; .178). In patients with positive CMV serology, the development of CMV events, including severe disease, does not seem to influence survival. The incidence of CLAD also is not increased by the presence of CMV events.</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.transproceed.2021.08.043</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-1743-2964</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0041-1345
ispartof Transplantation proceedings, 2021-11, Vol.53 (9), p.2734-2738
issn 0041-1345
1873-2623
language eng
recordid cdi_proquest_miscellaneous_2578774737
source ScienceDirect Freedom Collection (Elsevier)
title Influence of Cytomegalovirus on the Survival of Cytomegalovirus-Seropositive Lung Transplant
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T06%3A26%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20Cytomegalovirus%20on%20the%20Survival%20of%20Cytomegalovirus-Seropositive%20Lung%20Transplant&rft.jtitle=Transplantation%20proceedings&rft.au=Revuelta-Salgado,%20Fernando&rft.date=2021-11&rft.volume=53&rft.issue=9&rft.spage=2734&rft.epage=2738&rft.pages=2734-2738&rft.issn=0041-1345&rft.eissn=1873-2623&rft_id=info:doi/10.1016/j.transproceed.2021.08.043&rft_dat=%3Cproquest_cross%3E2578774737%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2578774737&rft_id=info:pmid/&rft_els_id=S004113452100631X&rfr_iscdi=true