Surface modification with cholesteryl acetyl carnitine, a novel cationic agent, elevates cancer cell uptake of the PEGylated liposomes

[Display omitted] •A novel cationic agent named cholesteryl acetyl carnitine (CAC) was synthesized.•CAC effectively interacts with CAT, CPT, OCTN1 and OCTN2.•CAC/PEG modified and CAC + PEG modified liposomes were prepared and characterized.•Co-modified liposomes with PEG and CAC demonstrated higher...

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Veröffentlicht in:	International journal of pharmaceutics 2021-11, Vol.609, p.121148-121148, Article 121148
Hauptverfasser:	Zahednezhad, Fahimeh, Shahbazi Mojarrad, Javid, Zakeri-Milani, Parvin, Baradaran, Behzad, Mahmoudian, Mohammad, Sarfraz, Muhammad, Valizadeh, Hadi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl carnitine Acetylcarnitine Cancer therapy Cations Cell uptake Cholesterol Liposome surface modification Liposomes Molecular Docking Simulation Neoplasms - drug therapy Particle Size Polyethylene Glycols Synthesis
Online-Zugang:	Volltext
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