Biological evaluation and spectral characterization of a novel tetracenomycin X congener

The aromatic polyketide tetracenomycin X (TcmX) was recently found to be a potent inhibitor of protein synthesis; its binding site is located in a unique locus within the tunnel of the large ribosomal subunit. The distinct mode of action makes this relatively narrow class of aromatic polyketides pro...

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Veröffentlicht in:	Biochimie 2022-01, Vol.192, p.63-71
Hauptverfasser:	Alferova, Vera A., Maviza, Tinashe P., Biryukov, Mikhail V., Zakalyukina, Yuliya V., Lukianov, Dmitrii A., Skvortsov, Dmitry A., Vasilyeva, Lilia A., Tashlitsky, Vadim N., Polshakov, Vladimir I., Sergiev, Petr V., Korshun, Vladimir A., Osterman, Ilya A.
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Amycolatopsis - chemistry Amycolatopsis - metabolism Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Fluorescence HEK293 Cells Humans MCF-7 Cells Molecular Structure Naphthacenes - chemistry Naphthacenes - metabolism Naphthacenes - pharmacology Nuclear Magnetic Resonance, Biomolecular Polyketide antibiotics Spectral characteristics Structure-activity relationship Tetracenomycins
Online-Zugang:	Volltext
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