Antibody Deficiency, Chronic Lung Disease, and Comorbid Conditions: A Case-Based Approach
New emerging pulmonary phenotypes associated with antibody deficiency, such as neutrophilic asthma, frequent exacerbations of chronic obstructive pulmonary disease, and unexplained interstitial lung disease, particularly in younger adults, are discussed in this review through a case-based approach....
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Veröffentlicht in: | The journal of allergy and clinical immunology in practice (Cambridge, MA) MA), 2021-11, Vol.9 (11), p.3899-3908 |
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container_title | The journal of allergy and clinical immunology in practice (Cambridge, MA) |
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creator | Petrov, Andrej A. Adatia, Adil Jolles, Stephen Nair, Parameswaran Azar, Antoine Walter, Jolan E. |
description | New emerging pulmonary phenotypes associated with antibody deficiency, such as neutrophilic asthma, frequent exacerbations of chronic obstructive pulmonary disease, and unexplained interstitial lung disease, particularly in younger adults, are discussed in this review through a case-based approach. Also discussed in similar fashion are antibody deficiency syndromes that lead to end-stage lung disease and the indications for lung transplantation in primary immunodeficiency disease. These challenging cases require timely and individualized strategies for genetic and immunologic diagnosis, decisions about therapeutic approaches, and long-term monitoring. |
doi_str_mv | 10.1016/j.jaip.2021.09.031 |
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Also discussed in similar fashion are antibody deficiency syndromes that lead to end-stage lung disease and the indications for lung transplantation in primary immunodeficiency disease. 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These challenging cases require timely and individualized strategies for genetic and immunologic diagnosis, decisions about therapeutic approaches, and long-term monitoring.</description><subject>Antibiotics</subject><subject>Antibodies</subject><subject>Antibody deficiency</subject><subject>Asthma</subject><subject>Asthma - diagnosis</subject><subject>Asthma - epidemiology</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunodeficiency</subject><subject>Immunoglobulins</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Interstitial lung disease</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lung diseases</subject><subject>Lung Diseases, Interstitial - diagnosis</subject><subject>Lung Diseases, Interstitial - epidemiology</subject><subject>Lung transplant</subject><subject>Lung Transplantation</subject><subject>Mutation</subject><subject>Neutrophils</subject><subject>Obstructive lung disease</subject><subject>Patients</subject><subject>Phenotypes</subject><subject>Primary immunodeficiencies</subject><subject>Primary Immunodeficiency Diseases</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnosis</subject><subject>Pulmonary Disease, Chronic Obstructive - epidemiology</subject><subject>Quality of life</subject><subject>Vaccines</subject><issn>2213-2198</issn><issn>2213-2201</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1v2zAQhomiRRKk-QMZCgJdOkQqvySRQRdX6UcAA1naIRNBkaeGgk06pFTA_750nHToUA7HG5577_AgdElJTQltP071ZPyuZoTRmqiacPoKnTFGecUYoa9feqrkKbrIeSLlSdoRQU7QKReNYlyJM3S_CrMfotvjGxi99RDs_gr3DykGb_F6Cb_wjc9gMlxhExzu4zamwR-a4PzsY8jXeIX7AlSfS3F4tdulaOzDW_RmNJsMF8__Ofr59cuP_nu1vvt226_WleVSzBVV3SC6dmhc5yxwZ7lQrVUCiKCNcANRrRgYkFFI6rikoKRRxnTNaJSQQ8fP0Ydjbln7uECe9dZnC5uNCRCXrFnTya5tqGgL-v4fdIpLCuW6QineEiqZKhQ7UjbFnBOMepf81qS9pkQf3OtJH9zrg3tNlC7uy9C75-hl2IL7O_JiugCfjgAUF789JJ2fbIPzCeysXfT_y_8DYYSSYg</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Petrov, Andrej A.</creator><creator>Adatia, Adil</creator><creator>Jolles, Stephen</creator><creator>Nair, Parameswaran</creator><creator>Azar, Antoine</creator><creator>Walter, Jolan E.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Antibody Deficiency, Chronic Lung Disease, and Comorbid Conditions: A Case-Based Approach</title><author>Petrov, Andrej A. ; 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subjects | Antibiotics Antibodies Antibody deficiency Asthma Asthma - diagnosis Asthma - epidemiology Chronic obstructive pulmonary disease Humans Immune system Immunodeficiency Immunoglobulins Infections Inflammation Interstitial lung disease Leukocytes (neutrophilic) Lung diseases Lung Diseases, Interstitial - diagnosis Lung Diseases, Interstitial - epidemiology Lung transplant Lung Transplantation Mutation Neutrophils Obstructive lung disease Patients Phenotypes Primary immunodeficiencies Primary Immunodeficiency Diseases Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - epidemiology Quality of life Vaccines |
title | Antibody Deficiency, Chronic Lung Disease, and Comorbid Conditions: A Case-Based Approach |
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