Antibody Deficiency, Chronic Lung Disease, and Comorbid Conditions: A Case-Based Approach

New emerging pulmonary phenotypes associated with antibody deficiency, such as neutrophilic asthma, frequent exacerbations of chronic obstructive pulmonary disease, and unexplained interstitial lung disease, particularly in younger adults, are discussed in this review through a case-based approach....

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Veröffentlicht in:The journal of allergy and clinical immunology in practice (Cambridge, MA) MA), 2021-11, Vol.9 (11), p.3899-3908
Hauptverfasser: Petrov, Andrej A., Adatia, Adil, Jolles, Stephen, Nair, Parameswaran, Azar, Antoine, Walter, Jolan E.
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container_issue 11
container_start_page 3899
container_title The journal of allergy and clinical immunology in practice (Cambridge, MA)
container_volume 9
creator Petrov, Andrej A.
Adatia, Adil
Jolles, Stephen
Nair, Parameswaran
Azar, Antoine
Walter, Jolan E.
description New emerging pulmonary phenotypes associated with antibody deficiency, such as neutrophilic asthma, frequent exacerbations of chronic obstructive pulmonary disease, and unexplained interstitial lung disease, particularly in younger adults, are discussed in this review through a case-based approach. Also discussed in similar fashion are antibody deficiency syndromes that lead to end-stage lung disease and the indications for lung transplantation in primary immunodeficiency disease. These challenging cases require timely and individualized strategies for genetic and immunologic diagnosis, decisions about therapeutic approaches, and long-term monitoring.
doi_str_mv 10.1016/j.jaip.2021.09.031
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subjects Antibiotics
Antibodies
Antibody deficiency
Asthma
Asthma - diagnosis
Asthma - epidemiology
Chronic obstructive pulmonary disease
Humans
Immune system
Immunodeficiency
Immunoglobulins
Infections
Inflammation
Interstitial lung disease
Leukocytes (neutrophilic)
Lung diseases
Lung Diseases, Interstitial - diagnosis
Lung Diseases, Interstitial - epidemiology
Lung transplant
Lung Transplantation
Mutation
Neutrophils
Obstructive lung disease
Patients
Phenotypes
Primary immunodeficiencies
Primary Immunodeficiency Diseases
Pulmonary Disease, Chronic Obstructive - diagnosis
Pulmonary Disease, Chronic Obstructive - epidemiology
Quality of life
Vaccines
title Antibody Deficiency, Chronic Lung Disease, and Comorbid Conditions: A Case-Based Approach
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