PD-1, CTLA-4, LAG-3, and TIGIT: The roles of immune checkpoint receptors on the regulation of human NK cell phenotype and functions

•Increased IL-10 production on PD-1+ NK, CTLA-4+ NK and LAG-3+ NK cells.•Impaired cytotoxic capacity on PD-1+ NK, CTLA-4+ NK and LAG-3+ NK cells.•PD-1+ NK, CTLA-4+ NK and LAG-3+ NK cells are resistant to K562 target cell stimulation.•TIGIT+ NK cells responded well to K562 target cell stimulation.•Pe...

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Veröffentlicht in:	Immunology letters 2021-12, Vol.240, p.15-23
Hauptverfasser:	Esen, Fehim, Deniz, Günnur, Aktas, Esin Cetin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - immunology CTLA-4 CTLA-4 Antigen - immunology Humans Immune regulation Killer Cells, Natural - immunology LAG-3 Lymphocyte Activation Gene 3 Protein Natural killer cells PD-1 Programmed Cell Death 1 Receptor - immunology Receptors, Immunologic - immunology TIGIT
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