Traumatic vertebra and endplate fractures promote adjacent disc degeneration: evidence from a clinical MR follow-up study
Objectives The integrity of endplate is important for maintaining the health of adjacent disc and trabeculae. Yet, pathological impacts of traumatic vertebra and endplate fractures were less studied using clinical approaches. This study aims to investigate their effects on the development of adjacen...
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| Veröffentlicht in: | Skeletal radiology 2022-05, Vol.51 (5), p.1017-1026 |
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| creator | Lu, Xuan Zhu, Zhiwei Pan, Jianjiang Feng, Zhiyun Lv, Xiaoqiang Battié, Michele C. Wang, Yue |
| description | Objectives
The integrity of endplate is important for maintaining the health of adjacent disc and trabeculae. Yet, pathological impacts of traumatic vertebra and endplate fractures were less studied using clinical approaches. This study aims to investigate their effects on the development of adjacent disc degeneration, segmental kyphosis, Modic changes (MCs), and high-intensity zones (HIZs).
Materials and methods
Magnetic resonance (MR) images of patients with acute traumatic vertebral compression fractures (T11-L5) were studied. On MR images, endplate fractures were evaluated as present or absent. Disc signal, height, bulging area, sagittal Cobb angle, MCs, and HIZs were measured on baseline and follow-up MR images to study the changes of the disc in relation to vertebra fractures and endplate fractures.
Results
Ninety-seven patients were followed up for 15.4 ± 14.0 months. There were 123 fractured vertebrae, including 79 (64.2%) with endplate fractures and 44 (35.8%) without. Both the adjacent and control discs decreased in signal and height over time (
p
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| doi_str_mv | 10.1007/s00256-021-03846-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2578763182</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A703949632</galeid><sourcerecordid>A703949632</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-b92ee8c7268a726bcf59135ea4ae5b3f58f5b7c3d49c4dccfd5f52ee63720d703</originalsourceid><addsrcrecordid>eNp9UU1rFTEUDaLYZ_UPuJCAGzdT850Zd6VYFSqC1HXIJDePecwkz2Sm5f17M52q4EICSbj3nHMP9yD0mpILSoh-XwhhUjWE0YbwVtTfE7SjgrOGUUWfoh3hSjSMi_YMvSjlQAjVWqrn6IwL2XVKix063Wa7THYeHL6DPEOfLbbRY4j-ONoZcMjWzUuGgo85TalWrD9YB3HGfigOe9hDhFwVUvyA4W7wEN1KSxO22I1DHJwd8dfvOKRxTPfNcsRlXvzpJXoW7Fjg1eN7jn5cf7y9-tzcfPv05erypnGCirnpOwbQOs1Ua-vVuyA7yiVYYUH2PMg2yF477kXnhHcueBlkpSiuGfGa8HP0btOt_n8uUGYzVd8wjjZCWophUrdacdqyCn37D_SQlhyrO8OUIFJzrlbBiw21tyOYIYY01x3V42EaXIoQhlq_rKM70Sm-yrKN4HIqJUMwxzxMNp8MJWZN0mxJmpqkeUjSrFPePHpZ-gn8H8rv6CqAb4BSW3EP-a_Z_8j-AusDqlM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2640573360</pqid></control><display><type>article</type><title>Traumatic vertebra and endplate fractures promote adjacent disc degeneration: evidence from a clinical MR follow-up study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Lu, Xuan ; Zhu, Zhiwei ; Pan, Jianjiang ; Feng, Zhiyun ; Lv, Xiaoqiang ; Battié, Michele C. ; Wang, Yue</creator><creatorcontrib>Lu, Xuan ; Zhu, Zhiwei ; Pan, Jianjiang ; Feng, Zhiyun ; Lv, Xiaoqiang ; Battié, Michele C. ; Wang, Yue</creatorcontrib><description>Objectives
The integrity of endplate is important for maintaining the health of adjacent disc and trabeculae. Yet, pathological impacts of traumatic vertebra and endplate fractures were less studied using clinical approaches. This study aims to investigate their effects on the development of adjacent disc degeneration, segmental kyphosis, Modic changes (MCs), and high-intensity zones (HIZs).
Materials and methods
Magnetic resonance (MR) images of patients with acute traumatic vertebral compression fractures (T11-L5) were studied. On MR images, endplate fractures were evaluated as present or absent. Disc signal, height, bulging area, sagittal Cobb angle, MCs, and HIZs were measured on baseline and follow-up MR images to study the changes of the disc in relation to vertebra fractures and endplate fractures.
Results
Ninety-seven patients were followed up for 15.4 ± 14.0 months. There were 123 fractured vertebrae, including 79 (64.2%) with endplate fractures and 44 (35.8%) without. Both the adjacent and control discs decreased in signal and height over time (
p
< 0.001), and the disc adjacent to vertebral fractures had greater signal and height loss than the control disc (
p
< 0.05). In the presence of endplate fractures, the adjacent discs had greater signal decrease in follow-up (
p
< 0.05), as compared to those without endplate fractures. Sagittal Cobb angle significantly increased in segments with endplate fractures (
p
< 0.05). Vertebra fractures were associated with new occurrence of MCs in the fractured vertebra (
p
< 0.001) but not HIZs in the adjacent disc.
Conclusions
Traumatic vertebral fractures were associated with accelerated adjacent disc degeneration, which appears to be further promoted by concomitant endplate fractures. Endplate fractures were associated with progression of segmental kyphosis.</description><identifier>ISSN: 0364-2348</identifier><identifier>EISSN: 1432-2161</identifier><identifier>DOI: 10.1007/s00256-021-03846-0</identifier><identifier>PMID: 34599674</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Compression ; Degeneration ; Degenerative disc disease ; Fractures ; Image compression ; Imaging ; Intervertebral discs ; Kyphosis ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Nuclear Medicine ; Orthopedics ; Pathology ; Patients ; Radiology ; Scientific Article ; Spine ; Vertebrae</subject><ispartof>Skeletal radiology, 2022-05, Vol.51 (5), p.1017-1026</ispartof><rights>ISS 2021</rights><rights>2021. ISS.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>ISS 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-b92ee8c7268a726bcf59135ea4ae5b3f58f5b7c3d49c4dccfd5f52ee63720d703</citedby><cites>FETCH-LOGICAL-c414t-b92ee8c7268a726bcf59135ea4ae5b3f58f5b7c3d49c4dccfd5f52ee63720d703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00256-021-03846-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00256-021-03846-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34599674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Xuan</creatorcontrib><creatorcontrib>Zhu, Zhiwei</creatorcontrib><creatorcontrib>Pan, Jianjiang</creatorcontrib><creatorcontrib>Feng, Zhiyun</creatorcontrib><creatorcontrib>Lv, Xiaoqiang</creatorcontrib><creatorcontrib>Battié, Michele C.</creatorcontrib><creatorcontrib>Wang, Yue</creatorcontrib><title>Traumatic vertebra and endplate fractures promote adjacent disc degeneration: evidence from a clinical MR follow-up study</title><title>Skeletal radiology</title><addtitle>Skeletal Radiol</addtitle><addtitle>Skeletal Radiol</addtitle><description>Objectives
The integrity of endplate is important for maintaining the health of adjacent disc and trabeculae. Yet, pathological impacts of traumatic vertebra and endplate fractures were less studied using clinical approaches. This study aims to investigate their effects on the development of adjacent disc degeneration, segmental kyphosis, Modic changes (MCs), and high-intensity zones (HIZs).
Materials and methods
Magnetic resonance (MR) images of patients with acute traumatic vertebral compression fractures (T11-L5) were studied. On MR images, endplate fractures were evaluated as present or absent. Disc signal, height, bulging area, sagittal Cobb angle, MCs, and HIZs were measured on baseline and follow-up MR images to study the changes of the disc in relation to vertebra fractures and endplate fractures.
Results
Ninety-seven patients were followed up for 15.4 ± 14.0 months. There were 123 fractured vertebrae, including 79 (64.2%) with endplate fractures and 44 (35.8%) without. Both the adjacent and control discs decreased in signal and height over time (
p
< 0.001), and the disc adjacent to vertebral fractures had greater signal and height loss than the control disc (
p
< 0.05). In the presence of endplate fractures, the adjacent discs had greater signal decrease in follow-up (
p
< 0.05), as compared to those without endplate fractures. Sagittal Cobb angle significantly increased in segments with endplate fractures (
p
< 0.05). Vertebra fractures were associated with new occurrence of MCs in the fractured vertebra (
p
< 0.001) but not HIZs in the adjacent disc.
Conclusions
Traumatic vertebral fractures were associated with accelerated adjacent disc degeneration, which appears to be further promoted by concomitant endplate fractures. Endplate fractures were associated with progression of segmental kyphosis.</description><subject>Compression</subject><subject>Degeneration</subject><subject>Degenerative disc disease</subject><subject>Fractures</subject><subject>Image compression</subject><subject>Imaging</subject><subject>Intervertebral discs</subject><subject>Kyphosis</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nuclear Medicine</subject><subject>Orthopedics</subject><subject>Pathology</subject><subject>Patients</subject><subject>Radiology</subject><subject>Scientific Article</subject><subject>Spine</subject><subject>Vertebrae</subject><issn>0364-2348</issn><issn>1432-2161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UU1rFTEUDaLYZ_UPuJCAGzdT850Zd6VYFSqC1HXIJDePecwkz2Sm5f17M52q4EICSbj3nHMP9yD0mpILSoh-XwhhUjWE0YbwVtTfE7SjgrOGUUWfoh3hSjSMi_YMvSjlQAjVWqrn6IwL2XVKix063Wa7THYeHL6DPEOfLbbRY4j-ONoZcMjWzUuGgo85TalWrD9YB3HGfigOe9hDhFwVUvyA4W7wEN1KSxO22I1DHJwd8dfvOKRxTPfNcsRlXvzpJXoW7Fjg1eN7jn5cf7y9-tzcfPv05erypnGCirnpOwbQOs1Ua-vVuyA7yiVYYUH2PMg2yF477kXnhHcueBlkpSiuGfGa8HP0btOt_n8uUGYzVd8wjjZCWophUrdacdqyCn37D_SQlhyrO8OUIFJzrlbBiw21tyOYIYY01x3V42EaXIoQhlq_rKM70Sm-yrKN4HIqJUMwxzxMNp8MJWZN0mxJmpqkeUjSrFPePHpZ-gn8H8rv6CqAb4BSW3EP-a_Z_8j-AusDqlM</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Lu, Xuan</creator><creator>Zhu, Zhiwei</creator><creator>Pan, Jianjiang</creator><creator>Feng, Zhiyun</creator><creator>Lv, Xiaoqiang</creator><creator>Battié, Michele C.</creator><creator>Wang, Yue</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20220501</creationdate><title>Traumatic vertebra and endplate fractures promote adjacent disc degeneration: evidence from a clinical MR follow-up study</title><author>Lu, Xuan ; Zhu, Zhiwei ; Pan, Jianjiang ; Feng, Zhiyun ; Lv, Xiaoqiang ; Battié, Michele C. ; Wang, Yue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-b92ee8c7268a726bcf59135ea4ae5b3f58f5b7c3d49c4dccfd5f52ee63720d703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Compression</topic><topic>Degeneration</topic><topic>Degenerative disc disease</topic><topic>Fractures</topic><topic>Image compression</topic><topic>Imaging</topic><topic>Intervertebral discs</topic><topic>Kyphosis</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nuclear Medicine</topic><topic>Orthopedics</topic><topic>Pathology</topic><topic>Patients</topic><topic>Radiology</topic><topic>Scientific Article</topic><topic>Spine</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Xuan</creatorcontrib><creatorcontrib>Zhu, Zhiwei</creatorcontrib><creatorcontrib>Pan, Jianjiang</creatorcontrib><creatorcontrib>Feng, Zhiyun</creatorcontrib><creatorcontrib>Lv, Xiaoqiang</creatorcontrib><creatorcontrib>Battié, Michele C.</creatorcontrib><creatorcontrib>Wang, Yue</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Skeletal radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Xuan</au><au>Zhu, Zhiwei</au><au>Pan, Jianjiang</au><au>Feng, Zhiyun</au><au>Lv, Xiaoqiang</au><au>Battié, Michele C.</au><au>Wang, Yue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Traumatic vertebra and endplate fractures promote adjacent disc degeneration: evidence from a clinical MR follow-up study</atitle><jtitle>Skeletal radiology</jtitle><stitle>Skeletal Radiol</stitle><addtitle>Skeletal Radiol</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>51</volume><issue>5</issue><spage>1017</spage><epage>1026</epage><pages>1017-1026</pages><issn>0364-2348</issn><eissn>1432-2161</eissn><abstract>Objectives
The integrity of endplate is important for maintaining the health of adjacent disc and trabeculae. Yet, pathological impacts of traumatic vertebra and endplate fractures were less studied using clinical approaches. This study aims to investigate their effects on the development of adjacent disc degeneration, segmental kyphosis, Modic changes (MCs), and high-intensity zones (HIZs).
Materials and methods
Magnetic resonance (MR) images of patients with acute traumatic vertebral compression fractures (T11-L5) were studied. On MR images, endplate fractures were evaluated as present or absent. Disc signal, height, bulging area, sagittal Cobb angle, MCs, and HIZs were measured on baseline and follow-up MR images to study the changes of the disc in relation to vertebra fractures and endplate fractures.
Results
Ninety-seven patients were followed up for 15.4 ± 14.0 months. There were 123 fractured vertebrae, including 79 (64.2%) with endplate fractures and 44 (35.8%) without. Both the adjacent and control discs decreased in signal and height over time (
p
< 0.001), and the disc adjacent to vertebral fractures had greater signal and height loss than the control disc (
p
< 0.05). In the presence of endplate fractures, the adjacent discs had greater signal decrease in follow-up (
p
< 0.05), as compared to those without endplate fractures. Sagittal Cobb angle significantly increased in segments with endplate fractures (
p
< 0.05). Vertebra fractures were associated with new occurrence of MCs in the fractured vertebra (
p
< 0.001) but not HIZs in the adjacent disc.
Conclusions
Traumatic vertebral fractures were associated with accelerated adjacent disc degeneration, which appears to be further promoted by concomitant endplate fractures. Endplate fractures were associated with progression of segmental kyphosis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34599674</pmid><doi>10.1007/s00256-021-03846-0</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0364-2348 |
| ispartof | Skeletal radiology, 2022-05, Vol.51 (5), p.1017-1026 |
| issn | 0364-2348 1432-2161 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2578763182 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Compression Degeneration Degenerative disc disease Fractures Image compression Imaging Intervertebral discs Kyphosis Magnetic resonance imaging Medicine Medicine & Public Health Nuclear Medicine Orthopedics Pathology Patients Radiology Scientific Article Spine Vertebrae |
| title | Traumatic vertebra and endplate fractures promote adjacent disc degeneration: evidence from a clinical MR follow-up study |
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