Synthesis and ex vivo biological evaluation of gallium-68 labelled NODAGA chelates assessing cardiac uptake and retention

Radiolabelled lipophilic cations can be used to non-invasively report on mitochondrial dysfunction in diseases such as cardiovascular disease, cardiotoxicity and cancer. Several such lipophilic cations are currently used clinically to map myocardial perfusion using SPECT imaging. Since PET offers si...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2021-10, Vol.50 (41), p.14695-14705
Hauptverfasser:	Osborne, Bradley E, Yue, Thomas T C, Waters, Edward C T, Baark, Friedrich, Southworth, Richard, Long, Nicholas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemistry Animals Cations Chelating Agents - chemical synthesis Chelating Agents - chemistry Depolarization Evaluation Gallium Gallium Radioisotopes - chemistry Heart - diagnostic imaging Heterocyclic Compounds, 1-Ring - chemistry Lipophilicity Medical imaging Myocardium - metabolism Pharmacokinetics Pharmacology Positron emission Positron-Emission Tomography Radioactive tracers Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry Rats Tomography
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