Algorithmic Approach Using Negative Pressure Wound Therapy Improved Survival for Patients with Synchronous Hypopharyngeal and Esophageal Cancer Undergoing Pharyngolaryngoesophagectomy with Gastric Tube Reconstruction
Background This study retrospectively analyzed the feasibility and surgical outcome of an algorithmic approach using negative pressure wound therapy for patients with synchronous hypopharyngeal and esophageal cancer undergoing pharyngolaryngoesophagectomy with gastric tube reconstruction. Methods Pa...
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| Veröffentlicht in: | Annals of surgical oncology 2021-12, Vol.28 (13), p.8996-9007 |
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| container_title | Annals of surgical oncology |
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| creator | Chang, Chao-Chun Tang, Wen-Ruei Huang, Wei-Li Chen, Ying-Yuan Yen, Yi-Ting Tseng, Yau-Lin |
| description | Background
This study retrospectively analyzed the feasibility and surgical outcome of an algorithmic approach using negative pressure wound therapy for patients with synchronous hypopharyngeal and esophageal cancer undergoing pharyngolaryngoesophagectomy with gastric tube reconstruction.
Methods
Patients undergoing pharyngolaryngoesophagectomy and gastric tube reconstruction for hypopharyngeal cancer between 2011 and 2019 were candidates for this study. Data were collected on patient demographics, comorbidities, performance status, cancer stage, treatment, complication, and survival. Survival analysis was performed using the Kaplan-Meier method. The Cox proportional hazards model was used for prognostic factors.
Results
The study enrolled 43 patients. Anastomotic leakage was found in 21 of the patients with a conventional surgical drain (61.9%) and in 10 of the 22 patients with negative pressure wound therapy (45.5%) (
p
= 0.280). Nine patients in the conventional drain group (42.9%) and two patients in the negative pressure wound therapy group (9.1%) had leakage-associated complications (
p
= 0.011). The incidence of pulmonary complications was higher in the conventional surgical drain group (9 vs 2;
p
= 0.011). The number of complications requiring surgery was higher in the conventional drain group (7 vs 0;
p
= 0.004). The overall survival in the negative pressure wound therapy group was better (hazard ratio [HR], 0.33; 95% confidence interval [CI], 0.15–0.76;
p
= 0.009). Negative pressure wound therapy was independently associated with overall survival (HR, 0.31; 95% CI, 0.13–0.77;
p
= 0.011).
Conclusions
Negative pressure wound therapy with an algorithmic approach improved the overall survival for the patients undergoing gastric tube reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal and esophageal cancer by preventing deadly complications secondary to anastomotic leakage |
| doi_str_mv | 10.1245/s10434-021-10365-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2577729859</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2577729859</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-97c673317521a9d11b8083efbe71010605c3decf5424922d093371d3e77b3feb3</originalsourceid><addsrcrecordid>eNp9kcuO1DAQRSMEYh7wAyyQJTZsMvgRx8my1ZqXNIIW0y2WkeNU0hkldrCTRvlTPofqSQMSC1Zll0_dKteNoneMXjGeyE-B0UQkMeUsZlSkMs5eROdMYipJM_YSzzTN4pyn8iy6COGJUqYEla-jM5HITPJcnkc_V13jfDvu-9aQ1TB4p82e7EJrG_IZGj22ByAbDyFMHsg3N9mKbPfg9TCT-x7xA1TkcfKH9qA7UjtPNlgDdgzkB6qSx9mavXfWTYHczYMb9trPtgGENUpdh2Pm-brW1oAnO1uBb9yx_2ZhXbcEOLFmdP28qN_qMHocfDuVQL6CcRbvkxlbZ99Er2rdBXh7ipfR7uZ6u76LH77c3q9XD7ERSo5xrkyqhGBKcqbzirEyo5mAugTFKO6PSiMqMLVMeJJzXtFcCMUqAUqVooZSXEYfF13cxfcJwlj0bTDQddoCfrrgUinF80zmiH74B31yk7c4HVK5EmlCqUCKL5TxLgQPdTH4tscVFIwWR9-LxfcCfS-efS8yLHp_kp7KHqo_Jb-NRkAsQMAn3L__2_s_sr8AZeG-ig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2597364003</pqid></control><display><type>article</type><title>Algorithmic Approach Using Negative Pressure Wound Therapy Improved Survival for Patients with Synchronous Hypopharyngeal and Esophageal Cancer Undergoing Pharyngolaryngoesophagectomy with Gastric Tube Reconstruction</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Chang, Chao-Chun ; Tang, Wen-Ruei ; Huang, Wei-Li ; Chen, Ying-Yuan ; Yen, Yi-Ting ; Tseng, Yau-Lin</creator><creatorcontrib>Chang, Chao-Chun ; Tang, Wen-Ruei ; Huang, Wei-Li ; Chen, Ying-Yuan ; Yen, Yi-Ting ; Tseng, Yau-Lin</creatorcontrib><description>Background
This study retrospectively analyzed the feasibility and surgical outcome of an algorithmic approach using negative pressure wound therapy for patients with synchronous hypopharyngeal and esophageal cancer undergoing pharyngolaryngoesophagectomy with gastric tube reconstruction.
Methods
Patients undergoing pharyngolaryngoesophagectomy and gastric tube reconstruction for hypopharyngeal cancer between 2011 and 2019 were candidates for this study. Data were collected on patient demographics, comorbidities, performance status, cancer stage, treatment, complication, and survival. Survival analysis was performed using the Kaplan-Meier method. The Cox proportional hazards model was used for prognostic factors.
Results
The study enrolled 43 patients. Anastomotic leakage was found in 21 of the patients with a conventional surgical drain (61.9%) and in 10 of the 22 patients with negative pressure wound therapy (45.5%) (
p
= 0.280). Nine patients in the conventional drain group (42.9%) and two patients in the negative pressure wound therapy group (9.1%) had leakage-associated complications (
p
= 0.011). The incidence of pulmonary complications was higher in the conventional surgical drain group (9 vs 2;
p
= 0.011). The number of complications requiring surgery was higher in the conventional drain group (7 vs 0;
p
= 0.004). The overall survival in the negative pressure wound therapy group was better (hazard ratio [HR], 0.33; 95% confidence interval [CI], 0.15–0.76;
p
= 0.009). Negative pressure wound therapy was independently associated with overall survival (HR, 0.31; 95% CI, 0.13–0.77;
p
= 0.011).
Conclusions
Negative pressure wound therapy with an algorithmic approach improved the overall survival for the patients undergoing gastric tube reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal and esophageal cancer by preventing deadly complications secondary to anastomotic leakage</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-021-10365-8</identifier><identifier>PMID: 34585295</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Algorithms ; Anastomotic leak ; Cancer ; Demography ; Esophageal cancer ; Esophageal Neoplasms - surgery ; Esophagectomy - adverse effects ; Esophagus ; Feasibility studies ; Head and Neck Oncology ; Humans ; Medical prognosis ; Medicine ; Medicine & Public Health ; Negative-Pressure Wound Therapy ; Oncology ; Patients ; Pharyngectomy - adverse effects ; Pressure ; Retrospective Studies ; Surgery ; Surgical Oncology ; Survival ; Survival analysis ; Throat cancer ; Wound healing ; Wounds</subject><ispartof>Annals of surgical oncology, 2021-12, Vol.28 (13), p.8996-9007</ispartof><rights>Society of Surgical Oncology 2021</rights><rights>2021. Society of Surgical Oncology.</rights><rights>Society of Surgical Oncology 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-97c673317521a9d11b8083efbe71010605c3decf5424922d093371d3e77b3feb3</citedby><cites>FETCH-LOGICAL-c375t-97c673317521a9d11b8083efbe71010605c3decf5424922d093371d3e77b3feb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-021-10365-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-021-10365-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34585295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Chao-Chun</creatorcontrib><creatorcontrib>Tang, Wen-Ruei</creatorcontrib><creatorcontrib>Huang, Wei-Li</creatorcontrib><creatorcontrib>Chen, Ying-Yuan</creatorcontrib><creatorcontrib>Yen, Yi-Ting</creatorcontrib><creatorcontrib>Tseng, Yau-Lin</creatorcontrib><title>Algorithmic Approach Using Negative Pressure Wound Therapy Improved Survival for Patients with Synchronous Hypopharyngeal and Esophageal Cancer Undergoing Pharyngolaryngoesophagectomy with Gastric Tube Reconstruction</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
This study retrospectively analyzed the feasibility and surgical outcome of an algorithmic approach using negative pressure wound therapy for patients with synchronous hypopharyngeal and esophageal cancer undergoing pharyngolaryngoesophagectomy with gastric tube reconstruction.
Methods
Patients undergoing pharyngolaryngoesophagectomy and gastric tube reconstruction for hypopharyngeal cancer between 2011 and 2019 were candidates for this study. Data were collected on patient demographics, comorbidities, performance status, cancer stage, treatment, complication, and survival. Survival analysis was performed using the Kaplan-Meier method. The Cox proportional hazards model was used for prognostic factors.
Results
The study enrolled 43 patients. Anastomotic leakage was found in 21 of the patients with a conventional surgical drain (61.9%) and in 10 of the 22 patients with negative pressure wound therapy (45.5%) (
p
= 0.280). Nine patients in the conventional drain group (42.9%) and two patients in the negative pressure wound therapy group (9.1%) had leakage-associated complications (
p
= 0.011). The incidence of pulmonary complications was higher in the conventional surgical drain group (9 vs 2;
p
= 0.011). The number of complications requiring surgery was higher in the conventional drain group (7 vs 0;
p
= 0.004). The overall survival in the negative pressure wound therapy group was better (hazard ratio [HR], 0.33; 95% confidence interval [CI], 0.15–0.76;
p
= 0.009). Negative pressure wound therapy was independently associated with overall survival (HR, 0.31; 95% CI, 0.13–0.77;
p
= 0.011).
Conclusions
Negative pressure wound therapy with an algorithmic approach improved the overall survival for the patients undergoing gastric tube reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal and esophageal cancer by preventing deadly complications secondary to anastomotic leakage</description><subject>Algorithms</subject><subject>Anastomotic leak</subject><subject>Cancer</subject><subject>Demography</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy - adverse effects</subject><subject>Esophagus</subject><subject>Feasibility studies</subject><subject>Head and Neck Oncology</subject><subject>Humans</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Negative-Pressure Wound Therapy</subject><subject>Oncology</subject><subject>Patients</subject><subject>Pharyngectomy - adverse effects</subject><subject>Pressure</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival</subject><subject>Survival analysis</subject><subject>Throat cancer</subject><subject>Wound healing</subject><subject>Wounds</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kcuO1DAQRSMEYh7wAyyQJTZsMvgRx8my1ZqXNIIW0y2WkeNU0hkldrCTRvlTPofqSQMSC1Zll0_dKteNoneMXjGeyE-B0UQkMeUsZlSkMs5eROdMYipJM_YSzzTN4pyn8iy6COGJUqYEla-jM5HITPJcnkc_V13jfDvu-9aQ1TB4p82e7EJrG_IZGj22ByAbDyFMHsg3N9mKbPfg9TCT-x7xA1TkcfKH9qA7UjtPNlgDdgzkB6qSx9mavXfWTYHczYMb9trPtgGENUpdh2Pm-brW1oAnO1uBb9yx_2ZhXbcEOLFmdP28qN_qMHocfDuVQL6CcRbvkxlbZ99Er2rdBXh7ipfR7uZ6u76LH77c3q9XD7ERSo5xrkyqhGBKcqbzirEyo5mAugTFKO6PSiMqMLVMeJJzXtFcCMUqAUqVooZSXEYfF13cxfcJwlj0bTDQddoCfrrgUinF80zmiH74B31yk7c4HVK5EmlCqUCKL5TxLgQPdTH4tscVFIwWR9-LxfcCfS-efS8yLHp_kp7KHqo_Jb-NRkAsQMAn3L__2_s_sr8AZeG-ig</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Chang, Chao-Chun</creator><creator>Tang, Wen-Ruei</creator><creator>Huang, Wei-Li</creator><creator>Chen, Ying-Yuan</creator><creator>Yen, Yi-Ting</creator><creator>Tseng, Yau-Lin</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20211201</creationdate><title>Algorithmic Approach Using Negative Pressure Wound Therapy Improved Survival for Patients with Synchronous Hypopharyngeal and Esophageal Cancer Undergoing Pharyngolaryngoesophagectomy with Gastric Tube Reconstruction</title><author>Chang, Chao-Chun ; Tang, Wen-Ruei ; Huang, Wei-Li ; Chen, Ying-Yuan ; Yen, Yi-Ting ; Tseng, Yau-Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-97c673317521a9d11b8083efbe71010605c3decf5424922d093371d3e77b3feb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Algorithms</topic><topic>Anastomotic leak</topic><topic>Cancer</topic><topic>Demography</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy - adverse effects</topic><topic>Esophagus</topic><topic>Feasibility studies</topic><topic>Head and Neck Oncology</topic><topic>Humans</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Negative-Pressure Wound Therapy</topic><topic>Oncology</topic><topic>Patients</topic><topic>Pharyngectomy - adverse effects</topic><topic>Pressure</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival</topic><topic>Survival analysis</topic><topic>Throat cancer</topic><topic>Wound healing</topic><topic>Wounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Chao-Chun</creatorcontrib><creatorcontrib>Tang, Wen-Ruei</creatorcontrib><creatorcontrib>Huang, Wei-Li</creatorcontrib><creatorcontrib>Chen, Ying-Yuan</creatorcontrib><creatorcontrib>Yen, Yi-Ting</creatorcontrib><creatorcontrib>Tseng, Yau-Lin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Chao-Chun</au><au>Tang, Wen-Ruei</au><au>Huang, Wei-Li</au><au>Chen, Ying-Yuan</au><au>Yen, Yi-Ting</au><au>Tseng, Yau-Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Algorithmic Approach Using Negative Pressure Wound Therapy Improved Survival for Patients with Synchronous Hypopharyngeal and Esophageal Cancer Undergoing Pharyngolaryngoesophagectomy with Gastric Tube Reconstruction</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>28</volume><issue>13</issue><spage>8996</spage><epage>9007</epage><pages>8996-9007</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
This study retrospectively analyzed the feasibility and surgical outcome of an algorithmic approach using negative pressure wound therapy for patients with synchronous hypopharyngeal and esophageal cancer undergoing pharyngolaryngoesophagectomy with gastric tube reconstruction.
Methods
Patients undergoing pharyngolaryngoesophagectomy and gastric tube reconstruction for hypopharyngeal cancer between 2011 and 2019 were candidates for this study. Data were collected on patient demographics, comorbidities, performance status, cancer stage, treatment, complication, and survival. Survival analysis was performed using the Kaplan-Meier method. The Cox proportional hazards model was used for prognostic factors.
Results
The study enrolled 43 patients. Anastomotic leakage was found in 21 of the patients with a conventional surgical drain (61.9%) and in 10 of the 22 patients with negative pressure wound therapy (45.5%) (
p
= 0.280). Nine patients in the conventional drain group (42.9%) and two patients in the negative pressure wound therapy group (9.1%) had leakage-associated complications (
p
= 0.011). The incidence of pulmonary complications was higher in the conventional surgical drain group (9 vs 2;
p
= 0.011). The number of complications requiring surgery was higher in the conventional drain group (7 vs 0;
p
= 0.004). The overall survival in the negative pressure wound therapy group was better (hazard ratio [HR], 0.33; 95% confidence interval [CI], 0.15–0.76;
p
= 0.009). Negative pressure wound therapy was independently associated with overall survival (HR, 0.31; 95% CI, 0.13–0.77;
p
= 0.011).
Conclusions
Negative pressure wound therapy with an algorithmic approach improved the overall survival for the patients undergoing gastric tube reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal and esophageal cancer by preventing deadly complications secondary to anastomotic leakage</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>34585295</pmid><doi>10.1245/s10434-021-10365-8</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2021-12, Vol.28 (13), p.8996-9007 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Algorithms Anastomotic leak Cancer Demography Esophageal cancer Esophageal Neoplasms - surgery Esophagectomy - adverse effects Esophagus Feasibility studies Head and Neck Oncology Humans Medical prognosis Medicine Medicine & Public Health Negative-Pressure Wound Therapy Oncology Patients Pharyngectomy - adverse effects Pressure Retrospective Studies Surgery Surgical Oncology Survival Survival analysis Throat cancer Wound healing Wounds |
| title | Algorithmic Approach Using Negative Pressure Wound Therapy Improved Survival for Patients with Synchronous Hypopharyngeal and Esophageal Cancer Undergoing Pharyngolaryngoesophagectomy with Gastric Tube Reconstruction |
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