Tunable multi-responsive nano-gated mesoporous silica nanoparticles as drug carriers

Tunable multi-responsive nano-gated mesoporous silica nanoparticles as drug carriers

Tunable multi-responsive mesoporous silica nanoparticles were prepared by post-condensation/surface modification of MCM-41 nanoparticles. Surface grafting of a poly(N,N-dimethylaminoethyl methacrylate)-based polymer containing disulfide bonds was achieved by a click reaction. Chemical modification,...

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Veröffentlicht in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2021-12, Vol.208, p.112119-112119, Article 112119
Hauptverfasser: Nechikkattu, Riyasudheen, Kong, Jungwon, Lee, Young-Shin, Moon, Hyun-Jung, Bae, Jae-Ho, Kim, Sun-Hee, Park, Sung Soo, Ha, Chang-Sik
Format: Artikel
Sprache:eng
Schlagworte:
doxorubicin
drug release
MCM-41
stimuli-responsive
surface grafting
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Zusammenfassung:Tunable multi-responsive mesoporous silica nanoparticles were prepared by post-condensation/surface modification of MCM-41 nanoparticles. Surface grafting of a poly(N,N-dimethylaminoethyl methacrylate)-based polymer containing disulfide bonds was achieved by a click reaction. Chemical modification, morphological characteristics, and textural properties of the nanoparticles were studied using multiple characterization techniques such as Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, small-angle X-ray scattering, and nitrogen adsorption/desorption behavior. The nanoparticles retained the meso-structural integrity of MCM41 and particle size
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2021.112119