Proximal tibial osteophyte volumes are correlated spatially and with knee alignment: a quantitative analysis suggesting the influence of biochemical and mechanical factors in the development of osteophytes
To characterize the differences and correlations in osteophyte volumes between and within proximal tibial compartments, and to assess the correlations between osteophyte volumes and the femorotibial angle. CT scans of 73 knees with predominantly medial femorotibial osteoarthritis (21 K/L2, 28 K/L3,...
Gespeichert in:
| Veröffentlicht in: | Osteoarthritis and cartilage 2021-12, Vol.29 (12), p.1691-1700 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1700 |
|---|---|
| container_issue | 12 |
| container_start_page | 1691 |
| container_title | Osteoarthritis and cartilage |
| container_volume | 29 |
| creator | Omoumi, P. Schuler, A. Babel, H. Stoffel, C. Jolles, B.M. Favre, J. |
| description | To characterize the differences and correlations in osteophyte volumes between and within proximal tibial compartments, and to assess the correlations between osteophyte volumes and the femorotibial angle.
CT scans of 73 knees with predominantly medial femorotibial osteoarthritis (21 K/L2, 28 K/L3, 24 K/L4) were retrospectively analyzed using a new, reproducible method measuring total and subregional osteophyte volumes in the medial and lateral compartments. Non-parametric statistics was used for comparison and correlation analyses.
Total osteophyte volumes were larger in the medial than in the lateral compartment for all severity groups (p |
| doi_str_mv | 10.1016/j.joca.2021.09.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2577458859</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1063458421009122</els_id><sourcerecordid>2577458859</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-e0b4b095f8a0147a86446e155ec650466577ba38109e28fb200671b5be7bb0bf3</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhSNERUvhBVggL9kkjJM4P4gNqviTKpUFrC3bmdz44tip7Vy4D8k74fQWuutqbPk7xzNzsuwVhYICbd7ui71ToiihpAX0BUD3JLugrCzzvmHV03SGpspr1tXn2fMQ9gBQUQrPsvOqZi2lVXeR_fnm3W89C0OiljoVFyK6ZTpGJAdn1hkDER6Jct6jEREHEhYRE2mORNiB_NJxIj8tIhFG7-yMNr4jgtyuwkYdE3lIL1aYY9CBhHW3wxC13ZE4IdF2NCtahcSNRGqnJpy1Sk1sxjOqSdi76yhUdD4k_k424AGNW7avNuFDx-FFdjYKE_Dlfb3Mfnz6-P3qS3598_nr1YfrXNUAMUeQtYSejZ0AWreia-q6QcoYqoZB3TSsbaWoOgo9lt0oS4CmpZJJbKUEOVaX2ZuT7-Ld7Zom4rMOCo0RFt0aeJkM0t471ie0PKHKuxA8jnzxad_-yCnwLUa-51uMfIuRQ89TjEn0-t5_lTMO_yX_ckvA-xOAacqDRs-D0tsmB-1RRT44_Zj_XxYgtG0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2577458859</pqid></control><display><type>article</type><title>Proximal tibial osteophyte volumes are correlated spatially and with knee alignment: a quantitative analysis suggesting the influence of biochemical and mechanical factors in the development of osteophytes</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Omoumi, P. ; Schuler, A. ; Babel, H. ; Stoffel, C. ; Jolles, B.M. ; Favre, J.</creator><creatorcontrib>Omoumi, P. ; Schuler, A. ; Babel, H. ; Stoffel, C. ; Jolles, B.M. ; Favre, J.</creatorcontrib><description>To characterize the differences and correlations in osteophyte volumes between and within proximal tibial compartments, and to assess the correlations between osteophyte volumes and the femorotibial angle.
CT scans of 73 knees with predominantly medial femorotibial osteoarthritis (21 K/L2, 28 K/L3, 24 K/L4) were retrospectively analyzed using a new, reproducible method measuring total and subregional osteophyte volumes in the medial and lateral compartments. Non-parametric statistics was used for comparison and correlation analyses.
Total osteophyte volumes were larger in the medial than in the lateral compartment for all severity groups (p < 0.05). Additionally, statistically significant differences were observed among subregions of the lateral compartment in K/L3 and K/L4 knees.
Statistically significant positive correlations were found between the medial and lateral total osteophyte volumes in K/L3 and K/L4 knees (ρ ≥ 0.44, p = 0.03), and among most subregional osteophyte volumes within each compartment in K/L3 knees. Markedly fewer statistically significant correlations were present in K/L2 and K/L4 knees.
In K/L3 knees, the femorotibial angle was statistically significantly positively correlated with the total osteophyte volume in the medial compartment (ρ = 0.50, p = 0.01), with osteophyte volumes in most medial subregions, and with the osteophyte volume in the lateral posterior subregion (ρ = 0.40, p = 0.05).
Quantitative assessment of osteophytes may bring insight on factors influencing their development. Positive correlations of osteophyte volumes found between and within compartments suggest the influence of biochemical mediators acting on the entire joint, while positive correlations between the femorotibial angle and osteophyte volumes suggest a role of mechanical factors. These hypotheses are to be further confirmed.</description><identifier>ISSN: 1063-4584</identifier><identifier>EISSN: 1522-9653</identifier><identifier>DOI: 10.1016/j.joca.2021.09.008</identifier><identifier>PMID: 34571138</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Computer Simulation ; Cross-Sectional Studies ; Female ; Humans ; Imaging, Three-Dimensional ; Knee ; Knee Joint - diagnostic imaging ; Male ; Middle Aged ; Osteoarthritis ; Osteoarthritis, Knee - diagnostic imaging ; Osteophyte ; Osteophyte - diagnostic imaging ; Retrospective Studies ; Segmentation ; Severity of Illness Index ; Tomography, X-Ray Computed ; Topography ; X-ray computed tomography</subject><ispartof>Osteoarthritis and cartilage, 2021-12, Vol.29 (12), p.1691-1700</ispartof><rights>2021 The Author(s)</rights><rights>Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-e0b4b095f8a0147a86446e155ec650466577ba38109e28fb200671b5be7bb0bf3</citedby><cites>FETCH-LOGICAL-c400t-e0b4b095f8a0147a86446e155ec650466577ba38109e28fb200671b5be7bb0bf3</cites><orcidid>0000-0002-3251-3666 ; 0000-0003-3513-7608</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.joca.2021.09.008$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34571138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Omoumi, P.</creatorcontrib><creatorcontrib>Schuler, A.</creatorcontrib><creatorcontrib>Babel, H.</creatorcontrib><creatorcontrib>Stoffel, C.</creatorcontrib><creatorcontrib>Jolles, B.M.</creatorcontrib><creatorcontrib>Favre, J.</creatorcontrib><title>Proximal tibial osteophyte volumes are correlated spatially and with knee alignment: a quantitative analysis suggesting the influence of biochemical and mechanical factors in the development of osteophytes</title><title>Osteoarthritis and cartilage</title><addtitle>Osteoarthritis Cartilage</addtitle><description>To characterize the differences and correlations in osteophyte volumes between and within proximal tibial compartments, and to assess the correlations between osteophyte volumes and the femorotibial angle.
CT scans of 73 knees with predominantly medial femorotibial osteoarthritis (21 K/L2, 28 K/L3, 24 K/L4) were retrospectively analyzed using a new, reproducible method measuring total and subregional osteophyte volumes in the medial and lateral compartments. Non-parametric statistics was used for comparison and correlation analyses.
Total osteophyte volumes were larger in the medial than in the lateral compartment for all severity groups (p < 0.05). Additionally, statistically significant differences were observed among subregions of the lateral compartment in K/L3 and K/L4 knees.
Statistically significant positive correlations were found between the medial and lateral total osteophyte volumes in K/L3 and K/L4 knees (ρ ≥ 0.44, p = 0.03), and among most subregional osteophyte volumes within each compartment in K/L3 knees. Markedly fewer statistically significant correlations were present in K/L2 and K/L4 knees.
In K/L3 knees, the femorotibial angle was statistically significantly positively correlated with the total osteophyte volume in the medial compartment (ρ = 0.50, p = 0.01), with osteophyte volumes in most medial subregions, and with the osteophyte volume in the lateral posterior subregion (ρ = 0.40, p = 0.05).
Quantitative assessment of osteophytes may bring insight on factors influencing their development. Positive correlations of osteophyte volumes found between and within compartments suggest the influence of biochemical mediators acting on the entire joint, while positive correlations between the femorotibial angle and osteophyte volumes suggest a role of mechanical factors. These hypotheses are to be further confirmed.</description><subject>Aged</subject><subject>Computer Simulation</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Knee</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Knee - diagnostic imaging</subject><subject>Osteophyte</subject><subject>Osteophyte - diagnostic imaging</subject><subject>Retrospective Studies</subject><subject>Segmentation</subject><subject>Severity of Illness Index</subject><subject>Tomography, X-Ray Computed</subject><subject>Topography</subject><subject>X-ray computed tomography</subject><issn>1063-4584</issn><issn>1522-9653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhSNERUvhBVggL9kkjJM4P4gNqviTKpUFrC3bmdz44tip7Vy4D8k74fQWuutqbPk7xzNzsuwVhYICbd7ui71ToiihpAX0BUD3JLugrCzzvmHV03SGpspr1tXn2fMQ9gBQUQrPsvOqZi2lVXeR_fnm3W89C0OiljoVFyK6ZTpGJAdn1hkDER6Jct6jEREHEhYRE2mORNiB_NJxIj8tIhFG7-yMNr4jgtyuwkYdE3lIL1aYY9CBhHW3wxC13ZE4IdF2NCtahcSNRGqnJpy1Sk1sxjOqSdi76yhUdD4k_k424AGNW7avNuFDx-FFdjYKE_Dlfb3Mfnz6-P3qS3598_nr1YfrXNUAMUeQtYSejZ0AWreia-q6QcoYqoZB3TSsbaWoOgo9lt0oS4CmpZJJbKUEOVaX2ZuT7-Ld7Zom4rMOCo0RFt0aeJkM0t471ie0PKHKuxA8jnzxad_-yCnwLUa-51uMfIuRQ89TjEn0-t5_lTMO_yX_ckvA-xOAacqDRs-D0tsmB-1RRT44_Zj_XxYgtG0</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Omoumi, P.</creator><creator>Schuler, A.</creator><creator>Babel, H.</creator><creator>Stoffel, C.</creator><creator>Jolles, B.M.</creator><creator>Favre, J.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3251-3666</orcidid><orcidid>https://orcid.org/0000-0003-3513-7608</orcidid></search><sort><creationdate>202112</creationdate><title>Proximal tibial osteophyte volumes are correlated spatially and with knee alignment: a quantitative analysis suggesting the influence of biochemical and mechanical factors in the development of osteophytes</title><author>Omoumi, P. ; Schuler, A. ; Babel, H. ; Stoffel, C. ; Jolles, B.M. ; Favre, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-e0b4b095f8a0147a86446e155ec650466577ba38109e28fb200671b5be7bb0bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Computer Simulation</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Knee</topic><topic>Knee Joint - diagnostic imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Knee - diagnostic imaging</topic><topic>Osteophyte</topic><topic>Osteophyte - diagnostic imaging</topic><topic>Retrospective Studies</topic><topic>Segmentation</topic><topic>Severity of Illness Index</topic><topic>Tomography, X-Ray Computed</topic><topic>Topography</topic><topic>X-ray computed tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Omoumi, P.</creatorcontrib><creatorcontrib>Schuler, A.</creatorcontrib><creatorcontrib>Babel, H.</creatorcontrib><creatorcontrib>Stoffel, C.</creatorcontrib><creatorcontrib>Jolles, B.M.</creatorcontrib><creatorcontrib>Favre, J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoarthritis and cartilage</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Omoumi, P.</au><au>Schuler, A.</au><au>Babel, H.</au><au>Stoffel, C.</au><au>Jolles, B.M.</au><au>Favre, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proximal tibial osteophyte volumes are correlated spatially and with knee alignment: a quantitative analysis suggesting the influence of biochemical and mechanical factors in the development of osteophytes</atitle><jtitle>Osteoarthritis and cartilage</jtitle><addtitle>Osteoarthritis Cartilage</addtitle><date>2021-12</date><risdate>2021</risdate><volume>29</volume><issue>12</issue><spage>1691</spage><epage>1700</epage><pages>1691-1700</pages><issn>1063-4584</issn><eissn>1522-9653</eissn><abstract>To characterize the differences and correlations in osteophyte volumes between and within proximal tibial compartments, and to assess the correlations between osteophyte volumes and the femorotibial angle.
CT scans of 73 knees with predominantly medial femorotibial osteoarthritis (21 K/L2, 28 K/L3, 24 K/L4) were retrospectively analyzed using a new, reproducible method measuring total and subregional osteophyte volumes in the medial and lateral compartments. Non-parametric statistics was used for comparison and correlation analyses.
Total osteophyte volumes were larger in the medial than in the lateral compartment for all severity groups (p < 0.05). Additionally, statistically significant differences were observed among subregions of the lateral compartment in K/L3 and K/L4 knees.
Statistically significant positive correlations were found between the medial and lateral total osteophyte volumes in K/L3 and K/L4 knees (ρ ≥ 0.44, p = 0.03), and among most subregional osteophyte volumes within each compartment in K/L3 knees. Markedly fewer statistically significant correlations were present in K/L2 and K/L4 knees.
In K/L3 knees, the femorotibial angle was statistically significantly positively correlated with the total osteophyte volume in the medial compartment (ρ = 0.50, p = 0.01), with osteophyte volumes in most medial subregions, and with the osteophyte volume in the lateral posterior subregion (ρ = 0.40, p = 0.05).
Quantitative assessment of osteophytes may bring insight on factors influencing their development. Positive correlations of osteophyte volumes found between and within compartments suggest the influence of biochemical mediators acting on the entire joint, while positive correlations between the femorotibial angle and osteophyte volumes suggest a role of mechanical factors. These hypotheses are to be further confirmed.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>34571138</pmid><doi>10.1016/j.joca.2021.09.008</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3251-3666</orcidid><orcidid>https://orcid.org/0000-0003-3513-7608</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1063-4584 |
| ispartof | Osteoarthritis and cartilage, 2021-12, Vol.29 (12), p.1691-1700 |
| issn | 1063-4584 1522-9653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2577458859 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Computer Simulation Cross-Sectional Studies Female Humans Imaging, Three-Dimensional Knee Knee Joint - diagnostic imaging Male Middle Aged Osteoarthritis Osteoarthritis, Knee - diagnostic imaging Osteophyte Osteophyte - diagnostic imaging Retrospective Studies Segmentation Severity of Illness Index Tomography, X-Ray Computed Topography X-ray computed tomography |
| title | Proximal tibial osteophyte volumes are correlated spatially and with knee alignment: a quantitative analysis suggesting the influence of biochemical and mechanical factors in the development of osteophytes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T19%3A44%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Proximal%20tibial%20osteophyte%20volumes%20are%20correlated%20spatially%20and%20with%20knee%20alignment:%20a%20quantitative%20analysis%20suggesting%20the%20influence%20of%20biochemical%20and%20mechanical%20factors%20in%20the%20development%20of%20osteophytes&rft.jtitle=Osteoarthritis%20and%20cartilage&rft.au=Omoumi,%20P.&rft.date=2021-12&rft.volume=29&rft.issue=12&rft.spage=1691&rft.epage=1700&rft.pages=1691-1700&rft.issn=1063-4584&rft.eissn=1522-9653&rft_id=info:doi/10.1016/j.joca.2021.09.008&rft_dat=%3Cproquest_cross%3E2577458859%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2577458859&rft_id=info:pmid/34571138&rft_els_id=S1063458421009122&rfr_iscdi=true |